Homo sapiens Gene: SEPT8
Summary
InnateDB Gene IDBG-43102.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SEPT8
Gene Name septin 8
Synonyms SEP2;
Species Homo sapiens
Ensembl Gene ENSG00000164402
Encoded Proteins
septin 8
septin 8
septin 8
septin 8
septin 8
septin 8
septin 8
septin 8
septin 8
septin 8
septin 8
septin 8
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene is a member of the septin family of nucleotide binding proteins, originally described in yeast as cell division cycle regulatory proteins. Septins are highly conserved in yeast, Drosophila, and mouse, and appear to regulate cytoskeletal organization. Disruption of septin function disturbs cytokinesis and results in large multinucleate or polyploid cells. [provided by RefSeq, Jun 2012]
This gene is a member of the septin family of nucleotide binding proteins, originally described in yeast as cell division cycle regulatory proteins. Septins are highly conserved in yeast, Drosophila, and mouse, and appear to regulate cytoskeletal organization. Disruption of septin function disturbs cytokinesis and results in large multinucleate or polyploid cells. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2014]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:132750817-132807241
Strand Reverse strand
Band q31.1
Transcripts
ENST00000378721 ENSP00000367993
ENST00000378719 ENSP00000367991
ENST00000296873 ENSP00000296873
ENST00000378706 ENSP00000367978
ENST00000378701 ENSP00000367973
ENST00000378699 ENSP00000367971
ENST00000371493 ENSP00000360548
ENST00000371478
ENST00000448933 ENSP00000399840
ENST00000458488 ENSP00000394766
ENST00000453480 ENSP00000407421
ENST00000414594 ENSP00000411823
ENST00000481030
ENST00000481794
ENST00000492490
ENST00000620483 ENSP00000483876
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 22 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 22 [view]
Protein-Protein 22 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0005525 GTP binding
Biological Process
GO:0007049 cell cycle
Cellular Component
GO:0031105 septin complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
KEGG
Bacterial invasion of epithelial cells pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.522057 Hs.593258
RefSeq NM_001098811 NM_001098812 NM_001098813 NM_001300798 NM_001300799 NM_015146 XM_005271927 XM_005271928 XM_005271929 XM_005271931
HUGO
OMIM
CCDS CCDS43358 CCDS43359 CCDS43360 CCDS47262 CCDS75298
HPRD
IMGT
EMBL
GenPept
RNA Seq Atlas