Version 5.4
Homo sapiens Gene: WWOX
Summary
InnateDB Gene IDBG-43129.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol WWOX
Gene Name WW domain containing oxidoreductase
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000186153
Encoded Proteins
IDBP-43135
WW domain containing oxidoreductase
IDBP-294697
WW domain containing oxidoreductase
IDBP-294687
WW domain containing oxidoreductase
IDBP-294692
WW domain containing oxidoreductase
IDBP-595109
WW domain containing oxidoreductase
IDBP-753241
IDBP-753830
IDBP-752387
IDBP-751351
IDBP-807624
WW domain containing oxidoreductase
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary WW domain-containing proteins are found in all eukaryotes and play an important role in the regulation of a wide variety of cellular functions such as protein degradation, transcription, and RNA splicing. This gene encodes a protein which contains 2 WW domains and a short-chain dehydrogenase/reductase domain (SRD). The highest normal expression of this gene is detected in hormonally regulated tissues such as testis, ovary, and prostate. This expression pattern and the presence of an SRD domain suggest a role for this gene in steroid metabolism. The encoded protein is more than 90% identical to the mouse protein, which is an essential mediator of tumor necrosis factor-alpha-induced apoptosis, suggesting a similar, important role in apoptosis for the human protein. In addition, there is evidence that this gene behaves as a suppressor of tumor growth. Alternative splicing of this gene generates transcript variants that encode different isoforms. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 16:78099413-79212667
Strand Forward strand
Band q23.1
Transcripts
ENST00000355860 ENSP00000348119
ENST00000402655 ENSP00000384238
ENST00000406884 ENSP00000384495
ENST00000408984 ENSP00000386161
ENST00000539474 ENSP00000445210
ENST00000561846
ENST00000569332 ENSP00000454788
ENST00000562639
ENST00000566103
ENST00000562214
ENST00000565791
ENST00000569818 ENSP00000454485
ENST00000563358
ENST00000566662 ENSP00000454331
ENST00000566780 ENSP00000457230
ENST00000565562
ENST00000620008 ENSP00000482648
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 260 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Experimentally validated
Total 260 [view]
Protein-Protein 260 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0016491 oxidoreductase activity
GO:0019899 enzyme binding
GO:0046983 protein dimerization activity
GO:0048037 cofactor binding
GO:0050662 coenzyme binding
Biological Process
GO:0001649 osteoblast differentiation
GO:0008152 metabolic process
GO:0008202 steroid metabolic process
GO:0016055 Wnt signaling pathway
GO:0030178 negative regulation of Wnt signaling pathway
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0048705 skeletal system morphogenesis
GO:0055114 oxidation-reduction process
GO:0071560 cellular response to transforming growth factor beta stimulus
GO:0072332 intrinsic apoptotic signaling pathway by p53 class mediator
GO:0097191 extrinsic apoptotic signaling pathway
GO:2001238 positive regulation of extrinsic apoptotic signaling pathway
GO:2001241 positive regulation of extrinsic apoptotic signaling pathway in absence of ligand
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005794 Golgi apparatus
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0005902 microvillus
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000004637
View Gene Order
ENSBTAG00000015894
Not yet available
Pathways
NETPATH
REACTOME
REACT_116022
Nuclear signaling by ERBB4 pathway
REACT_115596
Signaling by ERBB4 pathway
REACT_111102
Signal Transduction pathway
KEGG
INOH
PID NCI
erbb4_pathway
ErbB4 signaling events
p73pathway
p73 transcription factor network
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.461453 Hs.734837
RefSeq NM_016373 NM_130791 NM_130844 XM_006721195
HUGO
OMIM
CCDS CCDS42196 CCDS42197
HPRD 05501
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca