Homo sapiens Gene: BCL2
Summary
InnateDB Gene IDBG-4354.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol BCL2
Gene Name B-cell CLL/lymphoma 2
Synonyms Bcl-2; PPP1R50;
Species Homo sapiens
Ensembl Gene ENSG00000171791
Encoded Proteins
B-cell CLL/lymphoma 2
B-cell CLL/lymphoma 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
BCL2 is a multifunctional regulator of cell survival that inhibits the innate immune response during early stages of pathogenesis. Muscle-specific expression of BCL2 in Lama2-deficient mice resulted in the inhibition of TLR4, TLR6, TLR7, TLR8 and TLR9 induction, leading to reduced infiltration of eosinophils, the principal death effector cells. (Demonstrated in murine model)
InnateDB Annotation from Orthologs
Summary
[Mus musculus] Bcl2 is a multifunctional regulator of cell survival that inhibits the innate immune response during early stages of pathogenesis. Muscle-specific expression of Bcl2 in Lama2-deficient mice resulted in the inhibition of Tlr4, Tlr6, Tlr7, Tlr8 and Tlr9 induction, leading to reduced infiltration of eosinophils, the principal death effector cells.
[Mus musculus] Microbiota-driven Il17c induces Bcl2 and Bcl2l1 expression in intestinal epithelial cells in an autocrine manner to promote cell survival and tumorigenesis in both chemically induced and spontaneous intestinal tumor models.
Entrez Gene
Summary This gene encodes an integral outer mitochondrial membrane protein that blocks the apoptotic death of some cells such as lymphocytes. Constitutive expression of BCL2, such as in the case of translocation of BCL2 to Ig heavy chain locus, is thought to be the cause of follicular lymphoma. Two transcript variants, produced by alternate splicing, differ in their C-terminal ends. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 18:63123346-63320128
Strand Reverse strand
Band q21.33
Transcripts
ENST00000333681 ENSP00000329623
ENST00000398117 ENSP00000381185
ENST00000590515
ENST00000589955 ENSP00000466417
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 196 experimentally validated interaction(s) in this database.
They are also associated with 44 interaction(s) predicted by orthology.
Experimentally validated
Total 196 [view]
Protein-Protein 179 [view]
Protein-DNA 14 [view]
Protein-RNA 0
DNA-DNA 3 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 44 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0002020 protease binding
GO:0005515 protein binding
GO:0008134 transcription factor binding
GO:0015267 channel activity
GO:0016248 channel inhibitor activity
GO:0019903 protein phosphatase binding
GO:0031625 ubiquitin protein ligase binding
GO:0042802 identical protein binding
GO:0042803 protein homodimerization activity
GO:0043565 sequence-specific DNA binding
GO:0046982 protein heterodimerization activity
GO:0051434 BH3 domain binding
GO:0051721 protein phosphatase 2A binding
Biological Process
GO:0000209 protein polyubiquitination
GO:0000902 cell morphogenesis
GO:0001101 response to acid
GO:0001503 ossification
GO:0001541 ovarian follicle development
GO:0001656 metanephros development
GO:0001657 ureteric bud development
GO:0001658 branching involved in ureteric bud morphogenesis
GO:0001662 behavioral fear response
GO:0001776 leukocyte homeostasis
GO:0001782 B cell homeostasis
GO:0001822 kidney development
GO:0001836 release of cytochrome c from mitochondria
GO:0001952 regulation of cell-matrix adhesion
GO:0002260 lymphocyte homeostasis
GO:0002320 lymphoid progenitor cell differentiation
GO:0002326 B cell lineage commitment
GO:0002360 T cell lineage commitment
GO:0002520 immune system development
GO:0002931 response to ischemia
GO:0003014 renal system process
GO:0006470 protein dephosphorylation
GO:0006582 melanin metabolic process
GO:0006808 regulation of nitrogen utilization
GO:0006874 cellular calcium ion homeostasis
GO:0006915 apoptotic process
GO:0006959 humoral immune response
GO:0006974 cellular response to DNA damage stimulus
GO:0006979 response to oxidative stress
GO:0007015 actin filament organization
GO:0007409 axonogenesis
GO:0007565 female pregnancy
GO:0007569 cell aging
GO:0008283 cell proliferation
GO:0008284 positive regulation of cell proliferation
GO:0008285 negative regulation of cell proliferation
GO:0008584 male gonad development
GO:0008625 extrinsic apoptotic signaling pathway via death domain receptors
GO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage
GO:0008631 intrinsic apoptotic signaling pathway in response to oxidative stress
GO:0008637 apoptotic mitochondrial changes
GO:0009314 response to radiation
GO:0009636 response to toxic substance
GO:0009791 post-embryonic development
GO:0009887 organ morphogenesis
GO:0010039 response to iron ion
GO:0010224 response to UV-B
GO:0010332 response to gamma radiation
GO:0010468 regulation of gene expression
GO:0010507 negative regulation of autophagy
GO:0010523 negative regulation of calcium ion transport into cytosol
GO:0010559 regulation of glycoprotein biosynthetic process
GO:0014031 mesenchymal cell development
GO:0014042 positive regulation of neuron maturation
GO:0014911 positive regulation of smooth muscle cell migration
GO:0016049 cell growth
GO:0016337 single organismal cell-cell adhesion
GO:0018105 peptidyl-serine phosphorylation
GO:0018107 peptidyl-threonine phosphorylation
GO:0021747 cochlear nucleus development
GO:0022612 gland morphogenesis
GO:0022898 regulation of transmembrane transporter activity
GO:0030097 hemopoiesis
GO:0030183 B cell differentiation
GO:0030217 T cell differentiation
GO:0030279 negative regulation of ossification
GO:0030307 positive regulation of cell growth
GO:0030308 negative regulation of cell growth
GO:0030318 melanocyte differentiation
GO:0030336 negative regulation of cell migration
GO:0030890 positive regulation of B cell proliferation
GO:0031069 hair follicle morphogenesis
GO:0031103 axon regeneration
GO:0031647 regulation of protein stability
GO:0032469 endoplasmic reticulum calcium ion homeostasis
GO:0032835 glomerulus development
GO:0032848 negative regulation of cellular pH reduction
GO:0032880 regulation of protein localization
GO:0033033 negative regulation of myeloid cell apoptotic process
GO:0033077 T cell differentiation in thymus
GO:0033138 positive regulation of peptidyl-serine phosphorylation
GO:0033689 negative regulation of osteoblast proliferation
GO:0034097 response to cytokine
GO:0035094 response to nicotine
GO:0035265 organ growth
GO:0035872 nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway
GO:0040007 growth
GO:0040018 positive regulation of multicellular organism growth
GO:0042100 B cell proliferation
GO:0042149 cellular response to glucose starvation
GO:0042493 response to drug
GO:0042542 response to hydrogen peroxide
GO:0042981 regulation of apoptotic process
GO:0043029 T cell homeostasis
GO:0043066 negative regulation of apoptotic process
GO:0043067 regulation of programmed cell death
GO:0043085 positive regulation of catalytic activity
GO:0043375 CD8-positive, alpha-beta T cell lineage commitment
GO:0043473 pigmentation
GO:0043496 regulation of protein homodimerization activity
GO:0043497 regulation of protein heterodimerization activity
GO:0043524 negative regulation of neuron apoptotic process
GO:0043583 ear development
GO:0045069 regulation of viral genome replication
GO:0045087 innate immune response (InnateDB)
GO:0045636 positive regulation of melanocyte differentiation
GO:0045930 negative regulation of mitotic cell cycle
GO:0046671 negative regulation of retinal cell programmed cell death
GO:0046902 regulation of mitochondrial membrane permeability
GO:0048041 focal adhesion assembly
GO:0048066 developmental pigmentation
GO:0048070 regulation of developmental pigmentation
GO:0048087 positive regulation of developmental pigmentation
GO:0048536 spleen development
GO:0048538 thymus development
GO:0048545 response to steroid hormone
GO:0048546 digestive tract morphogenesis
GO:0048589 developmental growth
GO:0048599 oocyte development
GO:0048743 positive regulation of skeletal muscle fiber development
GO:0048753 pigment granule organization
GO:0048873 homeostasis of number of cells within a tissue
GO:0050790 regulation of catalytic activity
GO:0050853 B cell receptor signaling pathway
GO:0051384 response to glucocorticoid
GO:0051402 neuron apoptotic process
GO:0051607 defense response to virus
GO:0051726 regulation of cell cycle
GO:0051881 regulation of mitochondrial membrane potential
GO:0051902 negative regulation of mitochondrial depolarization
GO:0051924 regulation of calcium ion transport
GO:0055085 transmembrane transport
GO:0070059 intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
GO:0071310 cellular response to organic substance
GO:0071456 cellular response to hypoxia
GO:0072593 reactive oxygen species metabolic process
GO:0097192 extrinsic apoptotic signaling pathway in absence of ligand
GO:0097193 intrinsic apoptotic signaling pathway
GO:1900740 positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
GO:2000134 negative regulation of G1/S transition of mitotic cell cycle
GO:2000811 negative regulation of anoikis
GO:2001234 negative regulation of apoptotic signaling pathway
GO:2001240 negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
GO:2001243 negative regulation of intrinsic apoptotic signaling pathway
GO:2001244 positive regulation of intrinsic apoptotic signaling pathway
Cellular Component
GO:0005622 intracellular
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005741 mitochondrial outer membrane
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0005829 cytosol
GO:0016020 membrane
GO:0031965 nuclear membrane
GO:0031966 mitochondrial membrane
GO:0043209 myelin sheath
GO:0046930 pore complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
EGFR1 pathway
BCR pathway
IL2 pathway
IL3 pathway
REACTOME
Innate Immune System pathway
The NLRP1 inflammasome pathway
Apoptosis pathway
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways pathway
Activation of BH3-only proteins pathway
Immune System pathway
Inflammasomes pathway
BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members pathway
Intrinsic Pathway for Apoptosis pathway
Activation of BAD and translocation to mitochondria pathway
KEGG
Protein processing in endoplasmic reticulum pathway
Apoptosis pathway
Focal adhesion pathway
Neurotrophin signaling pathway pathway
Amyotrophic lateral sclerosis (ALS) pathway
Toxoplasmosis pathway
Pathways in cancer pathway
Colorectal cancer pathway
Prostate cancer pathway
Small cell lung cancer pathway
INOH
PID BIOCARTA
Inhibition of cellular proliferation by gleevec [Biocarta view]
Role of mitochondria in apoptotic signaling [Biocarta view]
Il-2 receptor beta chain in t cell activation [Biocarta view]
Telomeres telomerase cellular aging and immortality [Biocarta view]
Keratinocyte differentiation [Biocarta view]
Stress induction of hsp regulation [Biocarta view]
Melanocyte development and pigmentation pathway [Biocarta view]
Apoptotic signaling in response to dna damage [Biocarta view]
Hiv-1 nef: negative effector of fas and tnf [Biocarta view]
P53 signaling pathway [Biocarta view]
Transcription regulation by methyltransferase of carm1 [Biocarta view]
Regulation of bad phosphorylation [Biocarta view]
Ceramide signaling pathway [Biocarta view]
Il-7 signal transduction [Biocarta view]
PID NCI
Ceramide signaling pathway
Caspase Cascade in Apoptosis
RXR and RAR heterodimerization with other nuclear receptor
IL2-mediated signaling events
Direct p53 effectors
ATF-2 transcription factor network
Validated targets of C-MYC transcriptional repression
EPO signaling pathway
C-MYB transcription factor network
Signaling events mediated by Stem cell factor receptor (c-Kit)
IL2 signaling events mediated by STAT5
Role of Calcineurin-dependent NFAT signaling in lymphocytes
IL2 signaling events mediated by PI3K
HIV-1 Nef: Negative effector of Fas and TNF-alpha
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.150749 Hs.709992
RefSeq NM_000633 NM_000657
HUGO
OMIM
CCDS CCDS11981 CCDS45882
HPRD 01045
IMGT
EMBL
GenPept
RNA Seq Atlas