InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: BCL2

Summary

InnateDB Gene

IDBG-4354.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

BCL2

Gene Name

B-cell CLL/lymphoma 2

Synonyms

Bcl-2; PPP1R50;

Species

Homo sapiens

Ensembl Gene

ENSG00000171791

Encoded Proteins

IDBP-4356

B-cell CLL/lymphoma 2

IDBP-233841

B-cell CLL/lymphoma 2

IDBP-726731

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 21850221

BCL2 is a multifunctional regulator of cell survival that inhibits the innate immune response during early stages of pathogenesis. Muscle-specific expression of BCL2 in Lama2-deficient mice resulted in the inhibition of TLR4, TLR6, TLR7, TLR8 and TLR9 induction, leading to reduced infiltration of eosinophils, the principal death effector cells. (Demonstrated in murine model)

InnateDB Annotation from Orthologs

Summary

PMID 21850221

[Mus musculus] Bcl2 is a multifunctional regulator of cell survival that inhibits the innate immune response during early stages of pathogenesis. Muscle-specific expression of Bcl2 in Lama2-deficient mice resulted in the inhibition of Tlr4, Tlr6, Tlr7, Tlr8 and Tlr9 induction, leading to reduced infiltration of eosinophils, the principal death effector cells.

PMID 24412611

[Mus musculus] Microbiota-driven Il17c induces Bcl2 and Bcl2l1 expression in intestinal epithelial cells in an autocrine manner to promote cell survival and tumorigenesis in both chemically induced and spontaneous intestinal tumor models.

Entrez Gene

Summary

This gene encodes an integral outer mitochondrial membrane protein that blocks the apoptotic death of some cells such as lymphocytes. Constitutive expression of BCL2, such as in the case of translocation of BCL2 to Ig heavy chain locus, is thought to be the cause of follicular lymphoma. Two transcript variants, produced by alternate splicing, differ in their C-terminal ends. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 18:63123346-63320128

Strand

Reverse strand

Band

q21.33

Transcripts

ENST00000333681	ENSP00000329623
ENST00000398117	ENSP00000381185
ENST00000590515
ENST00000589955	ENSP00000466417

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 196 experimentally validated interaction(s) in this database.
They are also associated with 44 interaction(s) predicted by orthology.

Experimentally validated
Total	196 [view]
Protein-Protein	179 [view]
Protein-DNA	14 [view]
Protein-RNA	0
DNA-DNA	3 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	44 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0002020	protease binding
GO:0005515	protein binding
GO:0008134	transcription factor binding
GO:0015267	channel activity
GO:0016248	channel inhibitor activity
GO:0019903	protein phosphatase binding
GO:0031625	ubiquitin protein ligase binding
GO:0042802	identical protein binding
GO:0042803	protein homodimerization activity
GO:0043565	sequence-specific DNA binding
GO:0046982	protein heterodimerization activity
GO:0051434	BH3 domain binding
GO:0051721	protein phosphatase 2A binding

Biological Process

GO:0000209	protein polyubiquitination
GO:0000902	cell morphogenesis
GO:0001101	response to acid
GO:0001503	ossification
GO:0001541	ovarian follicle development
GO:0001656	metanephros development
GO:0001657	ureteric bud development
GO:0001658	branching involved in ureteric bud morphogenesis
GO:0001662	behavioral fear response
GO:0001776	leukocyte homeostasis
GO:0001782	B cell homeostasis
GO:0001822	kidney development
GO:0001836	release of cytochrome c from mitochondria
GO:0001952	regulation of cell-matrix adhesion
GO:0002260	lymphocyte homeostasis
GO:0002320	lymphoid progenitor cell differentiation
GO:0002326	B cell lineage commitment
GO:0002360	T cell lineage commitment
GO:0002520	immune system development
GO:0002931	response to ischemia
GO:0003014	renal system process
GO:0006470	protein dephosphorylation
GO:0006582	melanin metabolic process
GO:0006808	regulation of nitrogen utilization
GO:0006874	cellular calcium ion homeostasis
GO:0006915	apoptotic process
GO:0006959	humoral immune response
GO:0006974	cellular response to DNA damage stimulus
GO:0006979	response to oxidative stress
GO:0007015	actin filament organization
GO:0007409	axonogenesis
GO:0007565	female pregnancy
GO:0007569	cell aging
GO:0008283	cell proliferation
GO:0008284	positive regulation of cell proliferation
GO:0008285	negative regulation of cell proliferation
GO:0008584	male gonad development
GO:0008625	extrinsic apoptotic signaling pathway via death domain receptors
GO:0008630	intrinsic apoptotic signaling pathway in response to DNA damage
GO:0008631	intrinsic apoptotic signaling pathway in response to oxidative stress
GO:0008637	apoptotic mitochondrial changes
GO:0009314	response to radiation
GO:0009636	response to toxic substance
GO:0009791	post-embryonic development
GO:0009887	organ morphogenesis
GO:0010039	response to iron ion
GO:0010224	response to UV-B
GO:0010332	response to gamma radiation
GO:0010468	regulation of gene expression
GO:0010507	negative regulation of autophagy
GO:0010523	negative regulation of calcium ion transport into cytosol
GO:0010559	regulation of glycoprotein biosynthetic process
GO:0014031	mesenchymal cell development
GO:0014042	positive regulation of neuron maturation
GO:0014911	positive regulation of smooth muscle cell migration
GO:0016049	cell growth
GO:0016337	single organismal cell-cell adhesion
GO:0018105	peptidyl-serine phosphorylation
GO:0018107	peptidyl-threonine phosphorylation
GO:0021747	cochlear nucleus development
GO:0022612	gland morphogenesis
GO:0022898	regulation of transmembrane transporter activity
GO:0030097	hemopoiesis
GO:0030183	B cell differentiation
GO:0030217	T cell differentiation
GO:0030279	negative regulation of ossification
GO:0030307	positive regulation of cell growth
GO:0030308	negative regulation of cell growth
GO:0030318	melanocyte differentiation
GO:0030336	negative regulation of cell migration
GO:0030890	positive regulation of B cell proliferation
GO:0031069	hair follicle morphogenesis
GO:0031103	axon regeneration
GO:0031647	regulation of protein stability
GO:0032469	endoplasmic reticulum calcium ion homeostasis
GO:0032835	glomerulus development
GO:0032848	negative regulation of cellular pH reduction
GO:0032880	regulation of protein localization
GO:0033033	negative regulation of myeloid cell apoptotic process
GO:0033077	T cell differentiation in thymus
GO:0033138	positive regulation of peptidyl-serine phosphorylation
GO:0033689	negative regulation of osteoblast proliferation
GO:0034097	response to cytokine
GO:0035094	response to nicotine
GO:0035265	organ growth
GO:0035872	nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway
GO:0040007	growth
GO:0040018	positive regulation of multicellular organism growth
GO:0042100	B cell proliferation
GO:0042149	cellular response to glucose starvation
GO:0042493	response to drug
GO:0042542	response to hydrogen peroxide
GO:0042981	regulation of apoptotic process
GO:0043029	T cell homeostasis
GO:0043066	negative regulation of apoptotic process
GO:0043067	regulation of programmed cell death
GO:0043085	positive regulation of catalytic activity
GO:0043375	CD8-positive, alpha-beta T cell lineage commitment
GO:0043473	pigmentation
GO:0043496	regulation of protein homodimerization activity
GO:0043497	regulation of protein heterodimerization activity
GO:0043524	negative regulation of neuron apoptotic process
GO:0043583	ear development
GO:0045069	regulation of viral genome replication
GO:0045087	innate immune response (InnateDB)
GO:0045636	positive regulation of melanocyte differentiation
GO:0045930	negative regulation of mitotic cell cycle
GO:0046671	negative regulation of retinal cell programmed cell death
GO:0046902	regulation of mitochondrial membrane permeability
GO:0048041	focal adhesion assembly
GO:0048066	developmental pigmentation
GO:0048070	regulation of developmental pigmentation
GO:0048087	positive regulation of developmental pigmentation
GO:0048536	spleen development
GO:0048538	thymus development
GO:0048545	response to steroid hormone
GO:0048546	digestive tract morphogenesis
GO:0048589	developmental growth
GO:0048599	oocyte development
GO:0048743	positive regulation of skeletal muscle fiber development
GO:0048753	pigment granule organization
GO:0048873	homeostasis of number of cells within a tissue
GO:0050790	regulation of catalytic activity
GO:0050853	B cell receptor signaling pathway
GO:0051384	response to glucocorticoid
GO:0051402	neuron apoptotic process
GO:0051607	defense response to virus
GO:0051726	regulation of cell cycle
GO:0051881	regulation of mitochondrial membrane potential
GO:0051902	negative regulation of mitochondrial depolarization
GO:0051924	regulation of calcium ion transport
GO:0055085	transmembrane transport
GO:0070059	intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
GO:0071310	cellular response to organic substance
GO:0071456	cellular response to hypoxia
GO:0072593	reactive oxygen species metabolic process
GO:0097192	extrinsic apoptotic signaling pathway in absence of ligand
GO:0097193	intrinsic apoptotic signaling pathway
GO:1900740	positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
GO:2000134	negative regulation of G1/S transition of mitotic cell cycle
GO:2000811	negative regulation of anoikis
GO:2001234	negative regulation of apoptotic signaling pathway
GO:2001240	negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
GO:2001243	negative regulation of intrinsic apoptotic signaling pathway
GO:2001244	positive regulation of intrinsic apoptotic signaling pathway

Cellular Component

GO:0005622	intracellular
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005739	mitochondrion
GO:0005741	mitochondrial outer membrane
GO:0005783	endoplasmic reticulum
GO:0005789	endoplasmic reticulum membrane
GO:0005829	cytosol
GO:0016020	membrane
GO:0031965	nuclear membrane
GO:0031966	mitochondrial membrane
GO:0043209	myelin sheath
GO:0046930	pore complex