Version 5.4
Homo sapiens Gene: CDH13
Summary
InnateDB Gene IDBG-43918.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CDH13
Gene Name cadherin 13, H-cadherin (heart)
Synonyms CDHH; P105
Species Homo sapiens
Ensembl Gene ENSG00000140945
Encoded Proteins
IDBP-43920
cadherin 13, H-cadherin (heart)
IDBP-381230
cadherin 13, H-cadherin (heart)
IDBP-381232
cadherin 13, H-cadherin (heart)
IDBP-597218
cadherin 13, H-cadherin (heart)
IDBP-744878
IDBP-751198
IDBP-746063
IDBP-747171
IDBP-754670
IDBP-744792
IDBP-813075
cadherin 13
IDBP-813076
cadherin 13
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the cadherin superfamily. The encoded protein is localized to the surface of the cell membrane and is anchored by a GPI moiety, rather than by a transmembrane domain. The protein lacks the cytoplasmic domain characteristic of other cadherins, and so is not thought to be a cell-cell adhesion glycoprotein. This protein acts as a negative regulator of axon growth during neural differentiation. It also protects vascular endothelial cells from apoptosis due to oxidative stress, and is associated with resistance to atherosclerosis. The gene is hypermethylated in many types of cancer. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, May 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 16:82626803-83800640
Strand Forward strand
Band q23.3
Transcripts
ENST00000268613 ENSP00000268613
ENST00000431540 ENSP00000408632
ENST00000428848 ENSP00000394557
ENST00000539548 ENSP00000442225
ENST00000569454
ENST00000562307
ENST00000568770 ENSP00000457149
ENST00000562601 ENSP00000455781
ENST00000566333
ENST00000569455
ENST00000567445 ENSP00000456297
ENST00000569144 ENSP00000457914
ENST00000566620 ENSP00000454435
ENST00000565636 ENSP00000456491
ENST00000622885 ENSP00000483719
ENST00000615627 ENSP00000482651
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005509 calcium ion binding
GO:0005515 protein binding
GO:0030169 low-density lipoprotein particle binding
GO:0042803 protein homodimerization activity
GO:0045296 cadherin binding
GO:0055100 adiponectin binding
GO:0071813 lipoprotein particle binding
Biological Process
GO:0001938 positive regulation of endothelial cell proliferation
GO:0001954 positive regulation of cell-matrix adhesion
GO:0002040 sprouting angiogenesis
GO:0007156 homophilic cell adhesion
GO:0007162 negative regulation of cell adhesion
GO:0007266 Rho protein signal transduction
GO:0008285 negative regulation of cell proliferation
GO:0016339 calcium-dependent cell-cell adhesion
GO:0016601 Rac protein signal transduction
GO:0030032 lamellipodium assembly
GO:0030100 regulation of endocytosis
GO:0030335 positive regulation of cell migration
GO:0034329 cell junction assembly
GO:0034332 adherens junction organization
GO:0042058 regulation of epidermal growth factor receptor signaling pathway
GO:0043542 endothelial cell migration
GO:0043616 keratinocyte proliferation
GO:0045216 cell-cell junction organization
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0048661 positive regulation of smooth muscle cell proliferation
GO:0050850 positive regulation of calcium-mediated signaling
GO:0050927 positive regulation of positive chemotaxis
GO:0051668 localization within membrane
GO:0055096 low-density lipoprotein particle mediated signaling
Cellular Component
GO:0005615 extracellular space
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0005901 caveola
GO:0009897 external side of plasma membrane
GO:0016020 membrane
GO:0031225 anchored component of membrane
GO:0043005 neuron projection
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000031841
View Gene Order
ENSBTAG00000034373
Not yet available
Pathways
NETPATH
REACTOME
REACT_19195
Adherens junctions interactions pathway
REACT_111155
Cell-Cell communication pathway
REACT_20676
Cell junction organization pathway
REACT_19331
Cell-cell junction organization pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL F5H7W7 H3BRL7
UniProt Splice Variant
Entrez Gene 1012
UniGene Hs.654386
RefSeq NM_001220488 NM_001220489 NM_001220490 NM_001220491 NM_001220492 NM_001257
HUGO HGNC:1753
OMIM 601364
CCDS CCDS56009 CCDS56010 CCDS58485 CCDS58486 CCDS58487
HPRD 03219
IMGT
EMBL AC009028 AC009063 AC009119 AC009142 AC087189 AC092340 AC092351 AC098804 AC099506 AC106814 AC125793
GenPept
RNA Seq Atlas 1012

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca