Version 5.4
Homo sapiens Gene: NEK1
Summary
InnateDB Gene IDBG-44149.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol NEK1
Gene Name NIMA-related kinase 1
Synonyms NY-REN-55; SRPS2; SRPS2A; SRTD6
Species Homo sapiens
Ensembl Gene ENSG00000137601
Encoded Proteins
IDBP-379723
NIMA (never in mitosis gene a)-related kinase 1
IDBP-479989
NIMA (never in mitosis gene a)-related kinase 1
IDBP-476750
NIMA (never in mitosis gene a)-related kinase 1
IDBP-475840
NIMA (never in mitosis gene a)-related kinase 1
IDBP-481670
NIMA (never in mitosis gene a)-related kinase 1
IDBP-481426
NIMA (never in mitosis gene a)-related kinase 1
IDBP-479825
NIMA (never in mitosis gene a)-related kinase 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a serine/threonine kinase involved in cell cycle regulation. The encoded protein is found in a centrosomal complex with FEZ1, a neuronal protein that plays a role in axonal development. Defects in this gene are a cause of polycystic kidney disease (PKD). Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 4:169393275-169612629
Strand Reverse strand
Band q33
Transcripts
ENST00000439128 ENSP00000408020
ENST00000511633 ENSP00000423332
ENST00000510533 ENSP00000427653
ENST00000507142 ENSP00000424757
ENST00000512193 ENSP00000424938
ENST00000509912
ENST00000505119 ENSP00000421525
ENST00000510108 ENSP00000424152
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 29 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 29 [view]
Protein-Protein 28 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 1 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016772 transferase activity, transferring phosphorus-containing groups
GO:0046872 metal ion binding
Biological Process
GO:0006468 protein phosphorylation
GO:0006974 cellular response to DNA damage stimulus
GO:0007067 mitotic nuclear division
GO:0010212 response to ionizing radiation
GO:0018108 peptidyl-tyrosine phosphorylation
GO:0042384 cilium assembly
Cellular Component
GO:0000242 pericentriolar material
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005813 centrosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000031644
View Gene Order
ENSBTAG00000026915
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.481181 Hs.712780
RefSeq NM_001199397 NM_001199398 NM_001199399 NM_001199400 NM_012224
HUGO
OMIM
CCDS CCDS47162 CCDS56348 CCDS56349 CCDS56350 CCDS56351
HPRD 06847
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca