|Homo sapiens Gene: TLR8|
|Last Modified||2014-10-13 [Report errors or provide feedback]|
|Gene Name||toll-like receptor 8|
toll-like receptor 8
toll-like receptor 8
|Useful resources||Stemformatics EHFPI ImmGen|
TLR8 expression and function is highly up-regulated in colonic epithelium from patients with active inflammatory bowel disease (IBD), suggesting that TLR8 signalling is important in the pathogenesis of IBD.
Toll-like receptor 8 (TLR8), 7 and 9 form a functional subgroup within the TLR family that recognizes pathogen-associated molecular patterns in endosomal/lysosomal compartments.
TLR8 and TLR7 bind single-stranded RNA, stimulating dendritic cells (DCs) and macrophages to secrete interferon-alpha and pro-inflammatory, as well as regulatory, cytokines.
TLR8 signalling strongly promotes inflammatory lipid mediator biosynthesis, providing novel insights on innate immune response to viral infections.
TLR8 is activated in human monocytic cells following Helicobacter pylori phagocytosis and TLR8 single nucleotide polymorphism play a role in the modulation of TLR8-dependent microbicidal response of infected macrophages.
TLR7 and TLR8 are translocated from the endoplasmic reticulum to the endosome in the presence of antiphospholipid antibodies, as a consequence, plasmacytoid dendritic cells become dramatically sensitized to TLR7/8 agonists and this may play a role in systemic autoimmunity.
TLR8 binding of HIV ssRNA induces endosomal acidification and chromatin remodeling at the TNF-alpha promoter to promote TNF-alpha release in infected macrophages.
TLR8 binds to exosomal MIR21 and MIR29A secreted by tumour cells and initiates a prometastatic inflammatory response.
TLR8 plays a pathogenic role in disease whereby its expression is increased in patients with systemic arthritis and is correlated with the elevation of IL1B levels and disease status.
TLR8 binds degradation products of single-stranded RNA at two distinct sites. One site prefers uridine mononucleosides and the other site prefers short oligonucleotides.
TLR8-dependent detection of bacterial RNA is critical for triggering monocyte activation in response to infection with Streptococcus pyogenes.
|InnateDB Annotation from Orthologs|
[Mus musculus] Tlr7 and Tlr8 are translocated from the endoplasmic reticulum to the endosome in the presence of antiphospholipid antibodies, as a consequence, plasmacytoid dendritic cells become dramatically sensitized to Tlr7/8 agonists and this may play a role in systemic autoimmunity.
[Mus musculus] Tlr8 binding of HIV ssRNA induces endosomal acidification and chromatin remodeling at the TNF-alpha promoter to promote TNF-alpha release in infected macrophages. (Demonstrated in human)
The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This gene is predominantly expressed in lung and peripheral blood leukocytes, and lies in close proximity to another family member, TLR7, on chromosome X. [provided by RefSeq, Jul 2008]
|Genomic Location||Chromosome X:12906620-12923169|
|Number of Interactions||
This gene and/or its encoded proteins are associated with 15 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
MyD88 dependent cascade initiated on endosome pathway
Toll Like Receptor 7/8 (TLR7/8) Cascade pathway
Toll Like Receptor 9 (TLR9) Cascade pathway
Innate Immune System pathway
Toll-Like Receptors Cascades pathway
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation pathway
Immune System pathway
Trafficking and processing of endosomal TLR pathway
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling pathway
Toll-like receptor signaling pathway pathway
|UniProt Splice Variant|
|RefSeq||NM_016610 NM_138636 XM_005274543|
|EMBL||AB445666 AC005859 AC139705 AF245703 AF246971 AK075117 AK297024 AY358296 BC101076 BC101077 CH471074 DQ023132 DQ023133 DQ023134 DQ023135 DQ023136 DQ023137 DQ023138 DQ023139 DQ023140|
|GenPept||AAF64061 AAF78036 AAI01077 AAI01078 AAQ88663 AAZ95433 AAZ95434 AAZ95435 AAZ95436 AAZ95437 AAZ95438 AAZ95439 AAZ95440 AAZ95441 BAC11412 BAG55063 BAG59554 EAW98808 EAW98809|
|RNA Seq Atlas||51311|