Homo sapiens Gene: TAF1C
Summary
InnateDB Gene IDBG-44336.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TAF1C
Gene Name TATA box binding protein (TBP)-associated factor, RNA polymerase I, C, 110kDa
Synonyms MGC:39976; SL1; TAFI110; TAFI95;
Species Homo sapiens
Ensembl Gene ENSG00000103168
Encoded Proteins
TATA box binding protein (TBP)-associated factor, RNA polymerase I, C, 110kDa
TATA box binding protein (TBP)-associated factor, RNA polymerase I, C, 110kDa
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Initiation of transcription by RNA polymerase I requires the formation of a complex composed of the TATA-binding protein (TBP) and three TBP-associated factors (TAFs) specific for RNA polymerase I. This complex, known as SL1, binds to the core promoter of ribosomal RNA genes to position the polymerase properly and acts as a channel for regulatory signals. This gene encodes the largest SL1-specific TAF. Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 16:84177847-84187070
Strand Reverse strand
Band q24.1
Transcripts
ENST00000341690 ENSP00000345305
ENST00000541676 ENSP00000437900
ENST00000544090
ENST00000537450
ENST00000562330
ENST00000565544
ENST00000570117 ENSP00000455247
ENST00000564774
ENST00000565279
ENST00000568265 ENSP00000456101
ENST00000570270
ENST00000569609 ENSP00000454494
ENST00000566732 ENSP00000455933
ENST00000567759 ENSP00000455265
ENST00000566903 ENSP00000456133
ENST00000561955 ENSP00000456011
ENST00000564208
ENST00000566183
ENST00000569505 ENSP00000457281
ENST00000564454 ENSP00000457883
ENST00000562445
ENST00000563428 ENSP00000455787
ENST00000564345 ENSP00000454854
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 30 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Experimentally validated
Total 30 [view]
Protein-Protein 30 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0005515 protein binding
Biological Process
GO:0006355 regulation of transcription, DNA-templated
GO:0006360 transcription from RNA polymerase I promoter
GO:0006361 transcription initiation from RNA polymerase I promoter
GO:0006362 transcription elongation from RNA polymerase I promoter
GO:0006363 termination of RNA polymerase I transcription
GO:0006366 transcription from RNA polymerase II promoter
GO:0010467 gene expression
Cellular Component
GO:0005654 nucleoplasm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
RNA Polymerase I Transcription pathway
RNA Polymerase I Promoter Escape pathway
Epigenetic regulation of gene expression pathway
RNA Polymerase I Promoter Clearance pathway
NoRC negatively regulates rRNA expression pathway
SIRT1 negatively regulates rRNA Expression pathway
RNA Polymerase I Transcription Termination pathway
RNA Polymerase I Chain Elongation pathway
RNA Polymerase I Transcription Initiation pathway
RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription pathway
Gene Expression pathway
Negative epigenetic regulation of rRNA expression pathway
KEGG
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.153022
RefSeq NM_001243156 NM_001243157 NM_001243158 NM_001243159 NM_005679 NM_139353 XM_005256226 XM_005256227 XM_006721325 XM_006721328 XM_006721329
HUGO
OMIM
CCDS CCDS32496 CCDS45535 CCDS58488 CCDS58489
HPRD 05364
IMGT
EMBL
GenPept
RNA Seq Atlas