Version 5.4
Homo sapiens Gene: SKP1
Summary
InnateDB Gene IDBG-44621.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SKP1
Gene Name S-phase kinase-associated protein 1
Synonyms EMC19; OCP-II; OCP2; p19A; SKP1A; TCEB1L
Species Homo sapiens
Ensembl Gene ENSG00000113558
Encoded Proteins
IDBP-44623
S-phase kinase-associated protein 1
IDBP-44625
S-phase kinase-associated protein 1
IDBP-478294
S-phase kinase-associated protein 1
IDBP-479281
S-phase kinase-associated protein 1
IDBP-482470
S-phase kinase-associated protein 1
IDBP-476454
S-phase kinase-associated protein 1
IDBP-482658
S-phase kinase-associated protein 1
IDBP-479584
S-phase kinase-associated protein 1
IDBP-482588
S-phase kinase-associated protein 1
IDBP-483011
S-phase kinase-associated protein 1
IDBP-483647
S-phase kinase-associated protein 1
IDBP-484092
S-phase kinase-associated protein 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a component of SCF complexes, which are composed of this protein, cullin 1, a ring-box protein, and one member of the F-box family of proteins. This protein binds directly to the F-box motif found in F-box proteins. SCF complexes are involved in the regulated ubiquitination of specific protein substrates, which targets them for degradation by the proteosome. Specific F-box proteins recognize different target protein(s), and many specific SCF substrates have been identified including regulators of cell cycle progression and development. Studies have also characterized the protein as an RNA polymerase II elongation factor. Alternative splicing of this gene results in two transcript variants. A related pseudogene has been identified on chromosome 7. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:134148935-134177038
Strand Reverse strand
Band q31.1
Transcripts
ENST00000328392 ENSP00000331708
ENST00000353411 ENSP00000231487
ENST00000522552 ENSP00000429472
ENST00000521216 ENSP00000431067
ENST00000517691
ENST00000517625 ENSP00000429961
ENST00000523966 ENSP00000429995
ENST00000522855 ENSP00000429686
ENST00000519054 ENSP00000430885
ENST00000519321 ENSP00000429415
ENST00000520417 ENSP00000429996
ENST00000519718 ENSP00000430774
ENST00000524288
ENST00000523359 ENSP00000428962
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 280 experimentally validated interaction(s) in this database.
They are also associated with 30 interaction(s) predicted by orthology.
Experimentally validated
Total 280 [view]
Protein-Protein 279 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 30 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004842 ubiquitin-protein transferase activity
GO:0005515 protein binding
Biological Process
GO:0000082 G1/S transition of mitotic cell cycle
GO:0000086 G2/M transition of mitotic cell cycle
GO:0000278 mitotic cell cycle
GO:0006511 ubiquitin-dependent protein catabolic process
GO:0007219 Notch signaling pathway
GO:0016032 viral process
GO:0016567 protein ubiquitination
GO:0031145 anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process
GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
GO:0035518 histone H2A monoubiquitination
GO:0051437 positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
GO:0051439 regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
Cellular Component
GO:0005654 nucleoplasm
GO:0005829 cytosol
GO:0019005 SCF ubiquitin ligase complex
GO:0031467 Cul7-RING ubiquitin ligase complex
GO:0031519 PcG protein complex
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000036309
View Gene Order
ENSBTAG00000025191
Not yet available
Pathways
NETPATH
NetPath_3
Notch pathway
NetPath_7
TGF_beta_Receptor pathway
NetPath_9
TNFalpha pathway
REACTOME
REACT_6821
SCF-beta-TrCP mediated degradation of Emi1 pathway
REACT_6837
Regulation of APC/C activators between G1/S and early anaphase pathway
REACT_9003
SCF(Skp2)-mediated degradation of p27/p21 pathway
REACT_9029
Cyclin A:Cdk2-associated events at S phase entry pathway
REACT_1574
Cyclin E associated events during G1/S transition pathway
REACT_821
Cyclin D associated events in G1 pathway
REACT_160315
Regulation of PLK1 Activity at G2/M Transition pathway
REACT_75842
Antigen processing: Ubiquitination & Proteasome degradation pathway
REACT_22442
Interleukin-1 signaling pathway
REACT_115697
Prolactin receptor signaling pathway
REACT_118656
Activation of NF-kappaB in B cells pathway
REACT_116022
Nuclear signaling by ERBB4 pathway
REACT_115596
Signaling by ERBB4 pathway
REACT_118780
NOTCH1 Intracellular Domain Regulates Transcription pathway
REACT_11063
Degradation of beta-catenin by the destruction complex pathway
REACT_24941
Circadian Clock pathway
REACT_9031
Vpu mediated degradation of CD4 pathway
REACT_160243
Constitutive Signaling by NOTCH1 PEST Domain Mutants pathway
REACT_160305
Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling pathway
REACT_160254
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants pathway
REACT_228216
truncated APC mutants destabilize the destruction complex pathway
REACT_1590
G1 Phase pathway
REACT_228098
AXIN mutants destabilize the destruction complex, activating WNT signaling pathway
REACT_228143
APC truncation mutants are not K63 polyubiquitinated pathway
REACT_228134
Signaling by Hedgehog pathway
REACT_228243
AMER1 mutants destabilize the destruction complex pathway
REACT_160082
Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant pathway
REACT_228331
Signaling by WNT in cancer pathway
REACT_6828
APC/C-mediated degradation of cell cycle proteins pathway
REACT_228285
AXIN missense mutants destabilize the destruction complex pathway
REACT_21279
Regulation of mitotic cell cycle pathway
REACT_11045
Signaling by Wnt pathway
REACT_21267
Mitotic G1-G1/S phases pathway
REACT_160214
Signaling by NOTCH1 in Cancer pathway
REACT_75790
Cytokine Signaling in Immune system pathway
REACT_899
S Phase pathway
REACT_228196
APC truncation mutants have impaired AXIN binding pathway
REACT_206597
Degradation of GLI2 by the proteasome pathway
REACT_231645
GLI3 is processed to GLI3R by the proteasome pathway
REACT_228261
T41 mutants of beta-catenin aren't phosphorylated pathway
REACT_267605
Degradation of GLI1 by the proteasome pathway
REACT_160099
FBXW7 Mutants and NOTCH1 in Cancer pathway
REACT_1783
G1/S Transition pathway
REACT_111102
Signal Transduction pathway
REACT_267634
Hedgehog 'off' state pathway
REACT_228314
misspliced GSK3beta mutants stabilize beta-catenin pathway
REACT_228137
S45 mutants of beta-catenin aren't phosphorylated pathway
REACT_228048
deletions in the AMER1 gene destabilize the destruction complex pathway
REACT_115566
Cell Cycle pathway
REACT_75774
Adaptive Immune System pathway
REACT_6900
Immune System pathway
REACT_160301
Signaling by NOTCH1 PEST Domain Mutants in Cancer pathway
REACT_228159
S33 mutants of beta-catenin aren't phosphorylated pathway
REACT_228060
truncations of AMER1 destabilize the destruction complex pathway
REACT_228229
phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex pathway
REACT_22232
Signaling by Interleukins pathway
REACT_160248
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer pathway
REACT_299
Signaling by NOTCH pathway
REACT_2203
G2/M Transition pathway
REACT_228112
deletions in the AXIN genes in hepatocellular carcinoma result in elevated WNT signaling pathway
REACT_118859
Signaling by NOTCH1 pathway
REACT_152
Cell Cycle, Mitotic pathway
REACT_160133
Signaling by NOTCH1 HD Domain Mutants in Cancer pathway
REACT_228223
TCF7L2 mutants don't bind CTBP pathway
REACT_6185
HIV Infection pathway
REACT_75820
Class I MHC mediated antigen processing & presentation pathway
REACT_21391
Mitotic G2-G2/M phases pathway
REACT_6288
Host Interactions of HIV factors pathway
REACT_118773
Signaling by the B Cell Receptor (BCR) pathway
REACT_118638
Downstream signaling events of B Cell Receptor (BCR) pathway
REACT_228251
S37 mutants of beta-catenin aren't phosphorylated pathway
REACT_116125
Disease pathway
KEGG
hsa04310
Wnt signaling pathway pathway
hsa04350
TGF-beta signaling pathway pathway
hsa04110
Cell cycle pathway
hsa04120
Ubiquitin mediated proteolysis pathway
hsa04710
Circadian rhythm pathway
hsa04114
Oocyte meiosis pathway
hsa04141
Protein processing in endoplasmic reticulum pathway
INOH
INOH website
IL-1 signaling pathway pathway
INOH website
Toll-like receptor signaling pathway pathway
INOH website
Wnt signaling pathway pathway
INOH website
Hedgehog signaling pathway pathway
PID NCI
betacatenin_nuc_pathway
Regulation of nuclear beta catenin signaling and target gene transcription
betacatenin_deg_pathway
Degradation of beta catenin
notch_pathway
Notch signaling pathway
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.171626 Hs.617679 Hs.733173
RefSeq NM_006930 NM_170679
HUGO
OMIM
CCDS CCDS4171 CCDS4172
HPRD 03255
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca