Homo sapiens Gene: SKP1
Summary
InnateDB Gene IDBG-44621.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SKP1
Gene Name S-phase kinase-associated protein 1
Synonyms EMC19; OCP-II; OCP2; p19A; SKP1A; TCEB1L;
Species Homo sapiens
Ensembl Gene ENSG00000113558
Encoded Proteins
S-phase kinase-associated protein 1
S-phase kinase-associated protein 1
S-phase kinase-associated protein 1
S-phase kinase-associated protein 1
S-phase kinase-associated protein 1
S-phase kinase-associated protein 1
S-phase kinase-associated protein 1
S-phase kinase-associated protein 1
S-phase kinase-associated protein 1
S-phase kinase-associated protein 1
S-phase kinase-associated protein 1
S-phase kinase-associated protein 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a component of SCF complexes, which are composed of this protein, cullin 1, a ring-box protein, and one member of the F-box family of proteins. This protein binds directly to the F-box motif found in F-box proteins. SCF complexes are involved in the regulated ubiquitination of specific protein substrates, which targets them for degradation by the proteosome. Specific F-box proteins recognize different target protein(s), and many specific SCF substrates have been identified including regulators of cell cycle progression and development. Studies have also characterized the protein as an RNA polymerase II elongation factor. Alternative splicing of this gene results in two transcript variants. A related pseudogene has been identified on chromosome 7. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:134148935-134177038
Strand Reverse strand
Band q31.1
Transcripts
ENST00000328392 ENSP00000331708
ENST00000353411 ENSP00000231487
ENST00000522552 ENSP00000429472
ENST00000521216 ENSP00000431067
ENST00000517691
ENST00000517625 ENSP00000429961
ENST00000523966 ENSP00000429995
ENST00000522855 ENSP00000429686
ENST00000519054 ENSP00000430885
ENST00000519321 ENSP00000429415
ENST00000520417 ENSP00000429996
ENST00000519718 ENSP00000430774
ENST00000524288
ENST00000523359 ENSP00000428962
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 280 experimentally validated interaction(s) in this database.
They are also associated with 30 interaction(s) predicted by orthology.
Experimentally validated
Total 280 [view]
Protein-Protein 279 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 30 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004842 ubiquitin-protein transferase activity
GO:0005515 protein binding
Biological Process
GO:0000082 G1/S transition of mitotic cell cycle
GO:0000086 G2/M transition of mitotic cell cycle
GO:0000278 mitotic cell cycle
GO:0006511 ubiquitin-dependent protein catabolic process
GO:0007219 Notch signaling pathway
GO:0016032 viral process
GO:0016567 protein ubiquitination
GO:0031145 anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process
GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
GO:0035518 histone H2A monoubiquitination
GO:0051437 positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
GO:0051439 regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
Cellular Component
GO:0005654 nucleoplasm
GO:0005829 cytosol
GO:0019005 SCF ubiquitin ligase complex
GO:0031467 Cul7-RING ubiquitin ligase complex
GO:0031519 PcG protein complex
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Not yet available
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Pathways
NETPATH
Notch pathway
TGF_beta_Receptor pathway
TNFalpha pathway
REACTOME
truncated APC mutants destabilize the destruction complex pathway
Constitutive Signaling by NOTCH1 PEST Domain Mutants pathway
G1 Phase pathway
AXIN mutants destabilize the destruction complex, activating WNT signaling pathway
APC truncation mutants are not K63 polyubiquitinated pathway
Signaling by Hedgehog pathway
AMER1 mutants destabilize the destruction complex pathway
Circadian Clock pathway
Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant pathway
Signaling by WNT in cancer pathway
APC/C-mediated degradation of cell cycle proteins pathway
SCF-beta-TrCP mediated degradation of Emi1 pathway
AXIN missense mutants destabilize the destruction complex pathway
Regulation of mitotic cell cycle pathway
Regulation of APC/C activators between G1/S and early anaphase pathway
NOTCH1 Intracellular Domain Regulates Transcription pathway
Signaling by Wnt pathway
Mitotic G1-G1/S phases pathway
Signaling by NOTCH1 in Cancer pathway
Cytokine Signaling in Immune system pathway
S Phase pathway
Signaling by ERBB4 pathway
APC truncation mutants have impaired AXIN binding pathway
Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling pathway
Degradation of GLI2 by the proteasome pathway
GLI3 is processed to GLI3R by the proteasome pathway
Cyclin D associated events in G1 pathway
Degradation of beta-catenin by the destruction complex pathway
T41 mutants of beta-catenin aren't phosphorylated pathway
Degradation of GLI1 by the proteasome pathway
FBXW7 Mutants and NOTCH1 in Cancer pathway
G1/S Transition pathway
Signal Transduction pathway
Hedgehog 'off' state pathway
misspliced GSK3beta mutants stabilize beta-catenin pathway
S45 mutants of beta-catenin aren't phosphorylated pathway
Regulation of PLK1 Activity at G2/M Transition pathway
deletions in the AMER1 gene destabilize the destruction complex pathway
Cell Cycle pathway
Activation of NF-kappaB in B cells pathway
Prolactin receptor signaling pathway
Adaptive Immune System pathway
Immune System pathway
Antigen processing: Ubiquitination & Proteasome degradation pathway
Signaling by NOTCH1 PEST Domain Mutants in Cancer pathway
S33 mutants of beta-catenin aren't phosphorylated pathway
truncations of AMER1 destabilize the destruction complex pathway
Cyclin E associated events during G1/S transition pathway
phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex pathway
Signaling by Interleukins pathway
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer pathway
Signaling by NOTCH pathway
G2/M Transition pathway
Interleukin-1 signaling pathway
deletions in the AXIN genes in hepatocellular carcinoma result in elevated WNT signaling pathway
Signaling by NOTCH1 pathway
Cell Cycle, Mitotic pathway
Signaling by NOTCH1 HD Domain Mutants in Cancer pathway
TCF7L2 mutants don't bind CTBP pathway
HIV Infection pathway
Class I MHC mediated antigen processing & presentation pathway
SCF(Skp2)-mediated degradation of p27/p21 pathway
Mitotic G2-G2/M phases pathway
Host Interactions of HIV factors pathway
Signaling by the B Cell Receptor (BCR) pathway
Vpu mediated degradation of CD4 pathway
Downstream signaling events of B Cell Receptor (BCR) pathway
Nuclear signaling by ERBB4 pathway
S37 mutants of beta-catenin aren't phosphorylated pathway
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants pathway
Disease pathway
Cyclin A:Cdk2-associated events at S phase entry pathway
KEGG
Cell cycle pathway
Oocyte meiosis pathway
Ubiquitin mediated proteolysis pathway
Protein processing in endoplasmic reticulum pathway
Wnt signaling pathway pathway
TGF-beta signaling pathway pathway
Circadian rhythm pathway
INOH
Hedgehog signaling pathway pathway
IL-1 signaling pathway pathway
Toll-like receptor signaling pathway pathway
Wnt signaling pathway pathway
PID BIOCARTA
E2f1 destruction pathway [Biocarta view]
Cyclin e destruction pathway [Biocarta view]
Er associated degradation (erad) pathway [Biocarta view]
Regulation of p27 phosphorylation during cell cycle progression [Biocarta view]
PID NCI
Regulation of nuclear beta catenin signaling and target gene transcription
Degradation of beta catenin
Notch signaling pathway
Cross-References
SwissProt
TrEMBL E5RGM3 E7ERH2
UniProt Splice Variant
Entrez Gene 6500
UniGene Hs.171626 Hs.617679 Hs.733173
RefSeq NM_006930 NM_170679
HUGO HGNC:10899
OMIM 601434
CCDS CCDS4171 CCDS4172
HPRD 03255
IMGT
EMBL AC011336 AC104109
GenPept
RNA Seq Atlas 6500