Version 5.4
Homo sapiens Gene: STK24
Summary
InnateDB Gene IDBG-44849.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol STK24
Gene Name serine/threonine kinase 24
Synonyms HEL-S-95; MST3; MST3B; STE20; STK3
Species Homo sapiens
Ensembl Gene ENSG00000102572
Encoded Proteins
IDBP-44851
serine/threonine kinase 24
IDBP-44853
serine/threonine kinase 24
IDBP-235195
serine/threonine kinase 24
IDBP-372271
serine/threonine kinase 24
IDBP-372273
serine/threonine kinase 24
IDBP-588199
serine/threonine kinase 24
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The yeast 'Sterile 20' gene (STE20) functions upstream of the mitogen-activated protein kinase (MAPK) cascade. In mammals, protein kinases related to STE20 can be divided into 2 subfamilies based on their structure and regulation. Members of the PAK subfamily (see PAK3; MIM 300142) contain a C-terminal catalytic domain and an N-terminal regulatory domain that has a CDC42 (MIM 116952)-binding domain. In contrast, members of the GCK subfamily (see MAP4K2; MIM 603166), also called the Sps1 subfamily, have an N-terminal catalytic domain and a C-terminal regulatory domain without a CDC42-binding domain. STK24 belongs to the GCK subfamily of STE20-like kinases (Zhou et al., 2000 [PubMed 10644707]).[supplied by OMIM, Mar 2008]
This gene encodes a serine/threonine protein kinase that functions upstream of mitogen-activated protein kinase (MAPK) signaling. The encoded protein is cleaved into two chains by caspases; the N-terminal fragment (MST3/N) translocates to the nucleus and promotes programmed cells death. There is a pseudogene for this gene on chromosome X. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2013]
Gene Information
Type Protein coding
Genomic Location Chromosome 13:98445185-98577940
Strand Reverse strand
Band q32.2
Transcripts
ENST00000376554 ENSP00000365737
ENST00000376547 ENSP00000365730
ENST00000397517 ENSP00000380651
ENST00000418038 ENSP00000402810
ENST00000444574 ENSP00000402764
ENST00000491878
ENST00000481288
ENST00000539966 ENSP00000442539
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 86 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 86 [view]
Protein-Protein 84 [view]
Protein-DNA 1 [view]
Protein-RNA 1 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016772 transferase activity, transferring phosphorus-containing groups
GO:0046872 metal ion binding
Biological Process
GO:0006468 protein phosphorylation
GO:0006915 apoptotic process
GO:0006921 cellular component disassembly involved in execution phase of apoptosis
GO:0007165 signal transduction
GO:0008631 intrinsic apoptotic signaling pathway in response to oxidative stress
GO:0023014 signal transduction by phosphorylation
GO:0030336 negative regulation of cell migration
GO:0046777 protein autophosphorylation
GO:0048679 regulation of axon regeneration
GO:0097194 execution phase of apoptosis
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0016020 membrane
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000063410
View Gene Order
ENSBTAG00000032234
Not yet available
Pathways
NETPATH
REACTOME
REACT_107
Apoptotic cleavage of cellular proteins pathway
REACT_995
Apoptotic execution phase pathway
REACT_578
Apoptosis pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.508514 Hs.596915 Hs.639317 Hs.713712
RefSeq NM_001032296 NM_001286649 NM_003576 XM_005254078 XM_005254079
HUGO
OMIM
CCDS CCDS32001 CCDS66573 CCDS9488
HPRD 10385
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca