Homo sapiens Gene: HERC2
Summary
InnateDB Gene IDBG-4485.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol HERC2
Gene Name HECT and RLD domain containing E3 ubiquitin protein ligase 2
Synonyms D15F37S1; jdf2; MRT38; p528; SHEP1;
Species Homo sapiens
Ensembl Gene ENSG00000128731
Encoded Proteins
hect domain and RLD 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene belongs to the HERC gene family that encodes a group of unusually large proteins, which contain multiple structural domains. All members have at least 1 copy of an N-terminal region showing homology to the cell cycle regulator RCC1 and a C-terminal HECT (homologous to E6-AP C terminus) domain found in a number of E3 ubiquitin protein ligases. Genetic variations in this gene are associated with skin/hair/eye pigmentation variability. Multiple pseudogenes of this gene are located on chromosomes 15 and 16. [provided by RefSeq, Mar 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 15:28111040-28322152
Strand Reverse strand
Band q13.1
Transcripts
ENST00000261609 ENSP00000261609
ENST00000564383
ENST00000566635
ENST00000563945
ENST00000569772 ENSP00000457745
ENST00000569335
ENST00000567869
ENST00000563670
ENST00000564519
ENST00000564734 ENSP00000456237
ENST00000562136
ENST00000568206
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 58 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 58 [view]
Protein-Protein 57 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004842 ubiquitin-protein transferase activity
GO:0005085 guanyl-nucleotide exchange factor activity
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0016874 ligase activity
GO:0020037 heme binding
GO:0031625 ubiquitin protein ligase binding
GO:0032183 SUMO binding
GO:0046872 metal ion binding
Biological Process
GO:0006281 DNA repair
GO:0006886 intracellular protein transport
GO:0006974 cellular response to DNA damage stimulus
GO:0007283 spermatogenesis
GO:0016567 protein ubiquitination
GO:0042787 protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0043547 positive regulation of GTPase activity
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005743 mitochondrial inner membrane
GO:0005814 centriole
GO:0016020 membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Adaptive Immune System pathway
Immune System pathway
Antigen processing: Ubiquitination & Proteasome degradation pathway
Class I MHC mediated antigen processing & presentation pathway
KEGG
Ubiquitin mediated proteolysis pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.434890 Hs.655872 Hs.722313 Hs.722755 Hs.741019
RefSeq NM_004667 XM_005268276 XM_005268277 XM_006720726 XM_006720727
HUGO
OMIM
CCDS CCDS10021
HPRD 06905
IMGT
EMBL
GenPept
RNA Seq Atlas