Homo sapiens Gene: NPAS3
Summary
InnateDB Gene IDBG-4493.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol NPAS3
Gene Name neuronal PAS domain protein 3
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000151322
Encoded Proteins
neuronal PAS domain protein 3
neuronal PAS domain protein 3
neuronal PAS domain protein 3
neuronal PAS domain protein 3
neuronal PAS domain protein 3
neuronal PAS domain protein 3
neuronal PAS domain protein 3
neuronal PAS domain protein 3
neuronal PAS domain protein 3
neuronal PAS domain protein 3
neuronal PAS domain protein 3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the basic helix-loop-helix and PAS domain-containing family of transcription factors. The encoded protein is localized to the nucleus and may regulate genes involved in neurogenesis. Chromosomal abnormalities that affect the coding potential of this gene are associated with schizophrenia and mental retardation. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 14:32934933-33804176
Strand Forward strand
Band q13.1
Transcripts
ENST00000356141 ENSP00000348460
ENST00000346562 ENSP00000319610
ENST00000357798 ENSP00000350446
ENST00000551634 ENSP00000448373
ENST00000551492 ENSP00000450392
ENST00000548645 ENSP00000448916
ENST00000547068 ENSP00000449542
ENST00000549770
ENST00000551008 ENSP00000447213
ENST00000546849 ENSP00000446700
ENST00000552696 ENSP00000447858
ENST00000550662
ENST00000552874 ENSP00000448450
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0004871 signal transducer activity
GO:0005515 protein binding
GO:0046983 protein dimerization activity
Biological Process
GO:0001964 startle response
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0007165 signal transduction
GO:0007626 locomotory behavior
GO:0042711 maternal behavior
GO:0045893 positive regulation of transcription, DNA-templated
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.603919 Hs.657892 Hs.666708 Hs.687722 Hs.708668 Hs.734077
RefSeq NM_001164749 NM_001165893 NM_022123 NM_173159 XM_005267991 XM_005267992 XM_005267993
HUGO
OMIM
CCDS CCDS53891 CCDS53892 CCDS55912 CCDS9645
HPRD 11400
IMGT
EMBL
GenPept
RNA Seq Atlas