Homo sapiens Gene: PFKP
Summary
InnateDB Gene IDBG-45598.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PFKP
Gene Name phosphofructokinase, platelet
Synonyms ATP-PFK; PFK-C; PFK-P; PFKF;
Species Homo sapiens
Ensembl Gene ENSG00000067057
Encoded Proteins
phosphofructokinase, platelet
phosphofructokinase, platelet
phosphofructokinase, platelet
phosphofructokinase, platelet
phosphofructokinase, platelet
phosphofructokinase, platelet
phosphofructokinase, platelet
phosphofructokinase, platelet
phosphofructokinase, platelet
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The PFKP gene encodes the platelet isoform of phosphofructokinase (PFK) (ATP:D-fructose-6-phosphate-1-phosphotransferase, EC 2.7.1.11). PFK catalyzes the irreversible conversion of fructose-6-phosphate to fructose-1,6-bisphosphate and is a key regulatory enzyme in glycolysis. The PFKP gene, which maps to chromosome 10p, is also expressed in fibroblasts. See also the muscle (PFKM; MIM 610681) and liver (PFKL; MIM 171860) isoforms of phosphofructokinase, which map to chromosomes 12q13 and 21q22, respectively. Vora (1981) [PubMed 6451249] determined that full tetrameric phophofructokinase enzyme expressed in platelets can be composed of subunits P4, P3L, and P2L2.[supplied by OMIM, Mar 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 10:3066333-3137712
Strand Forward strand
Band p15.2
Transcripts
ENST00000381125 ENSP00000370517
ENST00000381075 ENSP00000370465
ENST00000381072 ENSP00000370462
ENST00000407806 ENSP00000385880
ENST00000421751
ENST00000415005 ENSP00000408858
ENST00000413079 ENSP00000387871
ENST00000433193 ENSP00000410275
ENST00000495715
ENST00000468050 ENSP00000476311
ENST00000460445
ENST00000607886 ENSP00000477128
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 41 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Experimentally validated
Total 41 [view]
Protein-Protein 41 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 5 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003872 6-phosphofructokinase activity
GO:0005524 ATP binding
GO:0032403 protein complex binding
GO:0046872 metal ion binding
Biological Process
GO:0005975 carbohydrate metabolic process
GO:0006002 fructose 6-phosphate metabolic process
GO:0006006 glucose metabolic process
GO:0006096 glycolytic process
GO:0044281 small molecule metabolic process
GO:0046835 carbohydrate phosphorylation
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005945 6-phosphofructokinase complex
GO:0016020 membrane
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Myoclonic epilepsy of Lafora pathway
Metabolism of carbohydrates pathway
Glycolysis pathway
Metabolism pathway
Disease pathway
Glucose metabolism pathway
Glycogen storage diseases pathway
KEGG
Glycolysis / Gluconeogenesis pathway
Pentose phosphate pathway pathway
Fructose and mannose metabolism pathway
Galactose metabolism pathway
INOH
Pentose phosphate cycle pathway
Glycolysis Gluconeogenesis pathway
PID BIOCARTA
Phosphoinositides and their downstream targets [Biocarta view]
PID NCI
Cross-References
SwissProt
TrEMBL B1APP6 V9GY25
UniProt Splice Variant
Entrez Gene 5214
UniGene Hs.26010
RefSeq NM_002627 NM_001242339 XM_005252467 XM_005252466
HUGO HGNC:8878
OMIM 171840
CCDS CCDS7059 CCDS55698
HPRD 01384
IMGT
EMBL AL451164 AL731533
GenPept
RNA Seq Atlas 5214