Version 5.4
Homo sapiens Gene: GRIP1
Summary
InnateDB Gene IDBG-45676.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol GRIP1
Gene Name glutamate receptor interacting protein 1
Synonyms GRIP
Species Homo sapiens
Ensembl Gene ENSG00000155974
Encoded Proteins
IDBP-45678
glutamate receptor interacting protein 1
IDBP-234054
glutamate receptor interacting protein 1
IDBP-594252
glutamate receptor interacting protein 1
IDBP-590126
glutamate receptor interacting protein 1
IDBP-586639
glutamate receptor interacting protein 1
IDBP-602049
glutamate receptor interacting protein 1
IDBP-588546
glutamate receptor interacting protein 1
IDBP-588479
glutamate receptor interacting protein 1
IDBP-601456
glutamate receptor interacting protein 1
IDBP-591414
glutamate receptor interacting protein 1
IDBP-588851
glutamate receptor interacting protein 1
IDBP-591556
glutamate receptor interacting protein 1
IDBP-588084
glutamate receptor interacting protein 1
IDBP-590431
glutamate receptor interacting protein 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the glutamate receptor interacting protein family. The encoded scaffold protein binds to and mediates the trafficking and membrane organization of a number of transmembrane proteins. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, May 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 12:66347431-66804186
Strand Reverse strand
Band q14.3
Transcripts
ENST00000359742 ENSP00000352780
ENST00000398016 ENSP00000381098
ENST00000538164 ENSP00000439053
ENST00000540854 ENSP00000443006
ENST00000538211 ENSP00000446047
ENST00000535323
ENST00000540433 ENSP00000446024
ENST00000536215 ENSP00000446011
ENST00000541299
ENST00000542021
ENST00000543172 ENSP00000443860
ENST00000535002 ENSP00000440918
ENST00000545666 ENSP00000439124
ENST00000542309 ENSP00000438500
ENST00000539540 ENSP00000443392
ENST00000541947 ENSP00000438921
ENST00000538373 ENSP00000446067
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 57 experimentally validated interaction(s) in this database.
They are also associated with 12 interaction(s) predicted by orthology.
Experimentally validated
Total 57 [view]
Protein-Protein 55 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 1 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 12 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003713 transcription coactivator activity
GO:0005515 protein binding
GO:0008013 beta-catenin binding
GO:0008022 protein C-terminus binding
GO:0030159 receptor signaling complex scaffold activity
GO:0050681 androgen receptor binding
Biological Process
GO:0007268 synaptic transmission
GO:0008104 protein localization
GO:0030521 androgen receptor signaling pathway
GO:0035556 intracellular signal transduction
GO:0045893 positive regulation of transcription, DNA-templated
Cellular Component
GO:0005783 endoplasmic reticulum
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0016023 cytoplasmic membrane-bounded vesicle
GO:0030054 cell junction
GO:0030425 dendrite
GO:0043005 neuron projection
GO:0045121 membrane raft
GO:0045211 postsynaptic membrane
GO:0055037 recycling endosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000034813
View Gene Order
ENSBTAG00000033726
Not yet available
Pathways
NETPATH
REACTOME
REACT_18422
Trafficking of GluR2-containing AMPA receptors pathway
REACT_18307
Trafficking of AMPA receptors pathway
REACT_13685
Neuronal System pathway
REACT_13477
Transmission across Chemical Synapses pathway
REACT_15370
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell pathway
REACT_18347
Glutamate Binding, Activation of AMPA Receptors and Synaptic Plasticity pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt Q9Y3R0
TrEMBL F5H424 F5H4P8 F5H5I0
UniProt Splice Variant
Entrez Gene 23426
UniGene Hs.505946
RefSeq NM_021150 XM_005268758 NM_001178074 XM_005268754 XM_005268755 XM_005268756 XM_005268757 XM_005268759
HUGO HGNC:18708
OMIM 604597
CCDS CCDS41807
HPRD
IMGT
EMBL AC022508 AC078888 AC078889 AC090710 AC122686 AC135251 AJ133439 BC115393 BC115394
GenPept AAI15394 AAI15395 CAB39895
RNA Seq Atlas 23426

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca