InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: CYP1B1

Summary

InnateDB Gene

IDBG-46038.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CYP1B1

Gene Name

cytochrome P450, family 1, subfamily B, polypeptide 1

Synonyms

CP1B; CYPIB1; GLC3A; P4501B1

Species

Homo sapiens

Ensembl Gene

ENSG00000138061

Encoded Proteins

IDBP-811634

cytochrome P450, family 1, subfamily B, polypeptide 1

IDBP-811638

cytochrome P450, family 1, subfamily B, polypeptide 1

IDBP-811632

cytochrome P450, family 1, subfamily B, polypeptide 1

IDBP-811635

cytochrome P450, family 1, subfamily B, polypeptide 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. The enzyme encoded by this gene localizes to the endoplasmic reticulum and metabolizes procarcinogens such as polycyclic aromatic hydrocarbons and 17beta-estradiol. Mutations in this gene have been associated with primary congenital glaucoma; therefore it is thought that the enzyme also metabolizes a signaling molecule involved in eye development, possibly a steroid. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 2:38066973-38109902

Strand

Reverse strand

Band

p22.2

Transcripts

ENST00000491456
ENST00000494864	ENSP00000479876
ENST00000492443
ENST00000490576	ENSP00000478839
ENST00000610745	ENSP00000478561
ENST00000614273	ENSP00000483678
ENST00000613082

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.

Experimentally validated
Total	3 [view]
Protein-Protein	2 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004497	monooxygenase activity
GO:0005506	iron ion binding
GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
GO:0016712	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
GO:0019825	oxygen binding
GO:0020037	heme binding
GO:0070330	aromatase activity

Biological Process

GO:0001525	angiogenesis
GO:0002930	trabecular meshwork development
GO:0006725	cellular aromatic compound metabolic process
GO:0006805	xenobiotic metabolic process
GO:0006809	nitric oxide biosynthetic process
GO:0007155	cell adhesion
GO:0007601	visual perception
GO:0008202	steroid metabolic process
GO:0008210	estrogen metabolic process
GO:0008285	negative regulation of cell proliferation
GO:0008631	intrinsic apoptotic signaling pathway in response to oxidative stress
GO:0009404	toxin metabolic process
GO:0009636	response to toxic substance
GO:0010575	positive regulation vascular endothelial growth factor production
GO:0016125	sterol metabolic process
GO:0019369	arachidonic acid metabolic process
GO:0019373	epoxygenase P450 pathway
GO:0030199	collagen fibril organization
GO:0030336	negative regulation of cell migration
GO:0032088	negative regulation of NF-kappaB transcription factor activity
GO:0033629	negative regulation of cell adhesion mediated by integrin
GO:0042572	retinol metabolic process
GO:0042574	retinal metabolic process
GO:0043065	positive regulation of apoptotic process
GO:0043542	endothelial cell migration
GO:0044281	small molecule metabolic process
GO:0045766	positive regulation of angiogenesis
GO:0046427	positive regulation of JAK-STAT cascade
GO:0046466	membrane lipid catabolic process
GO:0048514	blood vessel morphogenesis
GO:0055114	oxidation-reduction process
GO:0061298	retina vasculature development in camera-type eye
GO:0061304	retinal blood vessel morphogenesis
GO:0070301	cellular response to hydrogen peroxide
GO:0071407	cellular response to organic cyclic compound
GO:0071603	endothelial cell-cell adhesion
GO:0097267	omega-hydroxylase P450 pathway
GO:1901313	positive regulation of gene expression involved in extracellular matrix organization
GO:2000377	regulation of reactive oxygen species metabolic process