InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: FIGF

Summary

InnateDB Gene

IDBG-46123.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

FIGF

Gene Name

c-fos induced growth factor (vascular endothelial growth factor D)

Synonyms

VEGF-D; VEGFD

Species

Homo sapiens

Ensembl Gene

ENSG00000165197

Encoded Proteins

IDBP-46125

c-fos induced growth factor (vascular endothelial growth factor D)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The protein encoded by this gene is a member of the platelet-derived growth factor/vascular endothelial growth factor (PDGF/VEGF) family and is active in angiogenesis, lymphangiogenesis, and endothelial cell growth. This secreted protein undergoes a complex proteolytic maturation, generating multiple processed forms which bind and activate VEGFR-2 and VEGFR-3 receptors. This protein is structurally and functionally similar to vascular endothelial growth factor C. Read-through transcription has been observed between this locus and the upstream PIR (GeneID 8544) locus. [provided by RefSeq, Feb 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome X:15345591-15384376

Strand

Reverse strand

Band

p22.2

Transcripts

ENST00000297904	ENSP00000297904
ENST00000488351

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	6 [view]
Protein-Protein	5 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005161	platelet-derived growth factor receptor binding
GO:0005172	vascular endothelial growth factor receptor binding
GO:0005515	protein binding
GO:0008083	growth factor activity
GO:0042056	chemoattractant activity
GO:0042803	protein homodimerization activity
GO:0043185	vascular endothelial growth factor receptor 3 binding

Biological Process

GO:0001525	angiogenesis
GO:0002576	platelet degranulation
GO:0007596	blood coagulation
GO:0008283	cell proliferation
GO:0008284	positive regulation of cell proliferation
GO:0030154	cell differentiation
GO:0030168	platelet activation
GO:0048010	vascular endothelial growth factor receptor signaling pathway
GO:0050918	positive chemotaxis
GO:0050930	induction of positive chemotaxis
GO:0051781	positive regulation of cell division
GO:0060754	positive regulation of mast cell chemotaxis