Homo sapiens Gene: FIGF
Summary
InnateDB Gene IDBG-46123.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol FIGF
Gene Name c-fos induced growth factor (vascular endothelial growth factor D)
Synonyms VEGF-D; VEGFD;
Species Homo sapiens
Ensembl Gene ENSG00000165197
Encoded Proteins
c-fos induced growth factor (vascular endothelial growth factor D)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a member of the platelet-derived growth factor/vascular endothelial growth factor (PDGF/VEGF) family and is active in angiogenesis, lymphangiogenesis, and endothelial cell growth. This secreted protein undergoes a complex proteolytic maturation, generating multiple processed forms which bind and activate VEGFR-2 and VEGFR-3 receptors. This protein is structurally and functionally similar to vascular endothelial growth factor C. Read-through transcription has been observed between this locus and the upstream PIR (GeneID 8544) locus. [provided by RefSeq, Feb 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome X:15345591-15384376
Strand Reverse strand
Band p22.2
Transcripts
ENST00000297904 ENSP00000297904
ENST00000488351
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 6 [view]
Protein-Protein 5 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005161 platelet-derived growth factor receptor binding
GO:0005172 vascular endothelial growth factor receptor binding
GO:0005515 protein binding
GO:0008083 growth factor activity
GO:0042056 chemoattractant activity
GO:0042803 protein homodimerization activity
GO:0043185 vascular endothelial growth factor receptor 3 binding
Biological Process
GO:0001525 angiogenesis
GO:0002576 platelet degranulation
GO:0007596 blood coagulation
GO:0008283 cell proliferation
GO:0008284 positive regulation of cell proliferation
GO:0030154 cell differentiation
GO:0030168 platelet activation
GO:0048010 vascular endothelial growth factor receptor signaling pathway
GO:0050918 positive chemotaxis
GO:0050930 induction of positive chemotaxis
GO:0051781 positive regulation of cell division
GO:0060754 positive regulation of mast cell chemotaxis
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0016020 membrane
GO:0031093 platelet alpha granule lumen
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
VEGF ligand-receptor interactions pathway
Signaling by VEGF pathway
Platelet degranulation pathway
Platelet activation, signaling and aggregation pathway
Signal Transduction pathway
Response to elevated platelet cytosolic Ca2+ pathway
VEGF binds to VEGFR leading to receptor dimerization pathway
Hemostasis pathway
KEGG
Cytokine-cytokine receptor interaction pathway
Focal adhesion pathway
Pathways in cancer pathway
INOH
GPCR signaling pathway
VEGF signaling pathway pathway
PID BIOCARTA
PID NCI
VEGF and VEGFR signaling network
VEGFR3 signaling in lymphatic endothelium
Alpha9 beta1 integrin signaling events
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.11392
RefSeq NM_004469
HUGO
OMIM
CCDS CCDS14166
HPRD 02102
IMGT
EMBL
GenPept
RNA Seq Atlas