Homo sapiens Gene: BMX
Summary
InnateDB Gene IDBG-46340.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol BMX
Gene Name BMX non-receptor tyrosine kinase
Synonyms ETK; PSCTK2; PSCTK3;
Species Homo sapiens
Ensembl Gene ENSG00000102010
Encoded Proteins
BMX non-receptor tyrosine kinase
BMX non-receptor tyrosine kinase
BMX non-receptor tyrosine kinase
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
A tyrosine protein kinase that regulates TLR4 induced IL6 in macrophages independent of MAPK14 (p38-alpha) and NF-kappaB
Entrez Gene
Summary This gene encodes a non-receptor tyrosine kinase belonging to the Tec kinase family. The protein contains a PH-like domain, which mediates membrane targeting by binding to phosphatidylinositol 3,4,5-triphosphate (PIP3), and a SH2 domain that binds to tyrosine-phosphorylated proteins and functions in signal transduction. The protein is implicated in several signal transduction pathways including the Stat pathway, and regulates differentiation and tumorigenicity of several types of cancer cells. Multiple alternatively spliced variants, encoding the same protein, have been identified.[provided by RefSeq, Sep 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome X:15464246-15556529
Strand Forward strand
Band p22.2
Transcripts
ENST00000357607 ENSP00000350224
ENST00000348343 ENSP00000308774
ENST00000342014 ENSP00000340082
ENST00000463891
ENST00000489983
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 38 experimentally validated interaction(s) in this database.
Experimentally validated
Total 38 [view]
Protein-Protein 38 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0004715 non-membrane spanning protein tyrosine kinase activity
GO:0004871 signal transducer activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016772 transferase activity, transferring phosphorus-containing groups
GO:0046872 metal ion binding
Biological Process
GO:0006468 protein phosphorylation
GO:0006915 apoptotic process
GO:0006921 cellular component disassembly involved in execution phase of apoptosis
GO:0006950 response to stress
GO:0007155 cell adhesion
GO:0007165 signal transduction
GO:0007498 mesoderm development
GO:0018108 peptidyl-tyrosine phosphorylation
GO:0035556 intracellular signal transduction
GO:0045087 innate immune response (InnateDB)
GO:0046777 protein autophosphorylation
Cellular Component
GO:0005829 cytosol
GO:0032587 ruffle membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
IL6 pathway
REACTOME
Apoptotic execution phase pathway
Apoptosis pathway
Apoptotic cleavage of cellular proteins pathway
KEGG
INOH
PID BIOCARTA
PID NCI
Signaling events mediated by focal adhesion kinase
Angiopoietin receptor Tie2-mediated signaling
Cross-References
SwissProt P51813
TrEMBL
UniProt Splice Variant
Entrez Gene 660
UniGene Hs.495731
RefSeq NM_001721 NM_203281 XM_006724510
HUGO HGNC:1079
OMIM 300101
CCDS CCDS14168
HPRD
IMGT
EMBL AC097625 AF045459 BC016652 CH471074 U08341 X83107
GenPept AAA17744 AAC08966 AAH16652 CAA58169 EAW98889
RNA Seq Atlas 660