Version 5.4
Homo sapiens Gene: CASP3
Summary
InnateDB Gene IDBG-46394.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CASP3
Gene Name caspase 3, apoptosis-related cysteine peptidase
Synonyms CPP32; CPP32B; SCA-1
Species Homo sapiens
Ensembl Gene ENSG00000164305
Encoded Proteins
IDBP-46396
caspase 3, apoptosis-related cysteine peptidase
IDBP-243314
caspase 3, apoptosis-related cysteine peptidase
IDBP-243316
caspase 3, apoptosis-related cysteine peptidase
IDBP-380227
caspase 3, apoptosis-related cysteine peptidase
IDBP-475126
caspase 3, apoptosis-related cysteine peptidase
IDBP-479390
caspase 3, apoptosis-related cysteine peptidase
IDBP-813492
caspase 3, apoptosis-related cysteine peptidase
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein cleaves and activates caspases 6, 7 and 9, and the protein itself is processed by caspases 8, 9 and 10. It is the predominant caspase involved in the cleavage of amyloid-beta 4A precursor protein, which is associated with neuronal death in Alzheimer's disease. Alternative splicing of this gene results in two transcript variants that encode the same protein. [provided by RefSeq, Jul 2008]
This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein cleaves and activates caspases 6, 7 and 9, and the protein itself is processed by caspases 8, 9 and 10. It is the predominant caspase involved in the cleavage of amyloid-beta 4A precursor protein, which is associated with neuronal death in Alzheimer\'s disease. Alternative splicing of this gene results in two transcript variants that encode the same protein. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 4:184627696-184649509
Strand Reverse strand
Band q35.1
Transcripts
ENST00000308394 ENSP00000311032
ENST00000393588 ENSP00000377213
ENST00000393585 ENSP00000377210
ENST00000447121 ENSP00000407142
ENST00000523916 ENSP00000428929
ENST00000517513 ENSP00000428372
ENST00000613118 ENSP00000478339
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 199 experimentally validated interaction(s) in this database.
They are also associated with 17 interaction(s) predicted by orthology.
Experimentally validated
Total 199 [view]
Protein-Protein 197 [view]
Protein-DNA 0
Protein-RNA 2 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 17 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004190 aspartic-type endopeptidase activity
GO:0004197 cysteine-type endopeptidase activity
GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity
GO:0005515 protein binding
GO:0008233 peptidase activity
GO:0008234 cysteine-type peptidase activity
GO:0097153 cysteine-type endopeptidase activity involved in apoptotic process
GO:0097200 cysteine-type endopeptidase activity involved in execution phase of apoptosis
Biological Process
GO:0001782 B cell homeostasis
GO:0001836 release of cytochrome c from mitochondria
GO:0006309 apoptotic DNA fragmentation
GO:0006508 proteolysis
GO:0006915 apoptotic process
GO:0006921 cellular component disassembly involved in execution phase of apoptosis
GO:0006974 cellular response to DNA damage stimulus
GO:0007507 heart development
GO:0007605 sensory perception of sound
GO:0008625 extrinsic apoptotic signaling pathway via death domain receptors
GO:0008631 intrinsic apoptotic signaling pathway in response to oxidative stress
GO:0008635 activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c
GO:0009411 response to UV
GO:0009611 response to wounding
GO:0016485 protein processing
GO:0022617 extracellular matrix disassembly
GO:0030182 neuron differentiation
GO:0030198 extracellular matrix organization
GO:0030216 keratinocyte differentiation
GO:0030218 erythrocyte differentiation
GO:0030220 platelet formation
GO:0030889 negative regulation of B cell proliferation
GO:0034349 glial cell apoptotic process
GO:0034612 response to tumor necrosis factor
GO:0035329 hippo signaling
GO:0042981 regulation of apoptotic process
GO:0043029 T cell homeostasis
GO:0043065 positive regulation of apoptotic process
GO:0043066 negative regulation of apoptotic process
GO:0043281 regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043525 positive regulation of neuron apoptotic process
GO:0045165 cell fate commitment
GO:0045736 negative regulation of cyclin-dependent protein serine/threonine kinase activity
GO:0045786 negative regulation of cell cycle
GO:0046007 negative regulation of activated T cell proliferation
GO:0048011 neurotrophin TRK receptor signaling pathway
GO:0051402 neuron apoptotic process
GO:0071310 cellular response to organic substance
GO:0097190 apoptotic signaling pathway
GO:0097192 extrinsic apoptotic signaling pathway in absence of ligand
GO:0097193 intrinsic apoptotic signaling pathway
GO:0097194 execution phase of apoptosis
GO:1902510 regulation of apoptotic DNA fragmentation
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005886 plasma membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000031628
View Gene Order
ENSBTAG00000015874
Not yet available
Pathways
NETPATH
NetPath_1
Alpha6Beta4Integrin pathway
NetPath_2
AndrogenReceptor pathway
NetPath_9
TNFalpha pathway
NetPath_12
BCR pathway
NetPath_114
Oncostatin_M pathway
REACTOME
REACT_13526
NADE modulates death signalling pathway
REACT_118607
Signaling by Hippo pathway
REACT_1767
SMAC-mediated dissociation of IAP:caspase complexes pathway
REACT_2190
SMAC binds to IAPs pathway
REACT_607
Activation of caspases through apoptosome-mediated cleavage pathway
REACT_22128
Role of DCC in regulating apoptosis pathway
REACT_13541
Caspase-mediated cleavage of cytoskeletal proteins pathway
REACT_13579
Apoptotic cleavage of cell adhesion proteins pathway
REACT_107
Apoptotic cleavage of cellular proteins pathway
REACT_13532
Stimulation of the cell death response by PAK-2p34 pathway
REACT_13462
Activation of DNA fragmentation factor pathway
REACT_995
Apoptotic execution phase pathway
REACT_11061
Signalling by NGF pathway
REACT_118779
Extracellular matrix organization pathway
REACT_1213
Apoptosis induced DNA fragmentation pathway
REACT_666
SMAC-mediated apoptotic response pathway
REACT_118572
Degradation of the extracellular matrix pathway
REACT_13776
p75 NTR receptor-mediated signalling pathway
REACT_578
Apoptosis pathway
REACT_111102
Signal Transduction pathway
REACT_963
Apoptotic factor-mediated response pathway
REACT_831
Cytochrome c-mediated apoptotic response pathway
REACT_13720
Cell death signalling via NRAGE, NRIF and NADE pathway
REACT_964
Intrinsic Pathway for Apoptosis pathway
REACT_13648
Regulation of Apoptosis pathway
KEGG
hsa05210
Colorectal cancer pathway
hsa05120
Epithelial cell signaling in Helicobacter pylori infection pathway
hsa04210
Apoptosis pathway
hsa04010
MAPK signaling pathway pathway
hsa05010
Alzheimer's disease pathway
hsa04650
Natural killer cell mediated cytotoxicity pathway
hsa04115
p53 signaling pathway pathway
hsa05014
Amyotrophic lateral sclerosis (ALS) pathway
hsa05012
Parkinson's disease pathway
hsa05016
Huntington's disease pathway
hsa05200
Pathways in cancer pathway
hsa05416
Viral myocarditis pathway
hsa05146
Amoebiasis pathway
hsa05145
Toxoplasmosis pathway
INOH
INOH website
TNFR1 signaling pathway pathway
INOH website
Fas signaling pathway pathway
PID NCI
syndecan_2_pathway
Syndecan-2-mediated signaling events
caspase_pathway
Caspase Cascade in Apoptosis
lysophospholipid_pathway
LPA receptor mediated events
nfat_tfpathway
Calcineurin-regulated NFAT-dependent transcription in lymphocytes
p75ntrpathway
p75(NTR)-mediated signaling
nfat_3pathway
Role of Calcineurin-dependent NFAT signaling in lymphocytes
hivnefpathway
HIV-1 Nef: Negative effector of Fas and TNF-alpha
ajdiss_2pathway
Posttranslational regulation of adherens junction stability and dissassembly
faspathway
FAS (CD95) signaling pathway
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.141125
RefSeq NM_004346 NM_032991
HUGO
OMIM
CCDS CCDS3836
HPRD 02799
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca