Version 5.4
Homo sapiens Gene: BRD8
Summary
InnateDB Gene IDBG-46567.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol BRD8
Gene Name bromodomain containing 8
Synonyms p120; SMAP; SMAP2
Species Homo sapiens
Ensembl Gene ENSG00000112983
Encoded Proteins
IDBP-46569
bromodomain containing 8
IDBP-46571
bromodomain containing 8
IDBP-295635
bromodomain containing 8
IDBP-377585
bromodomain containing 8
IDBP-377593
bromodomain containing 8
IDBP-377597
bromodomain containing 8
IDBP-377601
bromodomain containing 8
IDBP-377615
bromodomain containing 8
IDBP-377620
bromodomain containing 8
IDBP-377623
bromodomain containing 8
IDBP-377624
bromodomain containing 8
IDBP-377629
bromodomain containing 8
IDBP-377631
bromodomain containing 8
IDBP-480694
bromodomain containing 8
IDBP-481616
bromodomain containing 8
IDBP-473645
bromodomain containing 8
IDBP-475747
bromodomain containing 8
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene interacts with thyroid hormone receptor in a ligand-dependent manner and enhances thyroid hormone-dependent activation from thyroid response elements. This protein contains a bromodomain and is thought to be a nuclear receptor coactivator. Three alternatively spliced transcript variants that encode distinct isoforms have been identified. [provided by RefSeq, Jul 2008]
The protein encoded by this gene interacts with thyroid hormone receptor in a ligand-dependent manner and enhances thyroid hormone-dependent activation from thyroid response elements. This protein contains a bromodomain and is thought to be a nuclear receptor coactivator. Multiple alternatively spliced transcript variants that encode distinct isoforms have been identified. [provided by RefSeq, Jul 2014]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:138139766-138178986
Strand Reverse strand
Band q31.2
Transcripts
ENST00000254900 ENSP00000254900
ENST00000230901 ENSP00000230901
ENST00000402931 ENSP00000384845
ENST00000427976 ENSP00000392646
ENST00000418329 ENSP00000398873
ENST00000454473 ENSP00000398067
ENST00000441656 ENSP00000398084
ENST00000411594 ENSP00000394330
ENST00000453824 ENSP00000407129
ENST00000428808 ENSP00000414625
ENST00000432618 ENSP00000398676
ENST00000425764
ENST00000450756 ENSP00000396487
ENST00000430331 ENSP00000407414
ENST00000472478 ENSP00000420884
ENST00000512140 ENSP00000427475
ENST00000460746
ENST00000489351
ENST00000515014
ENST00000506167 ENSP00000427126
ENST00000511898 ENSP00000426385
ENST00000483805
ENST00000463620
ENST00000471892
ENST00000515254
ENST00000471437
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 28 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 28 [view]
Protein-Protein 24 [view]
Protein-DNA 4 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0004887 thyroid hormone receptor activity
GO:0005515 protein binding
Biological Process
GO:0006325 chromatin organization
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006357 regulation of transcription from RNA polymerase II promoter
GO:0007165 signal transduction
GO:0007166 cell surface receptor signaling pathway
GO:0030522 intracellular receptor signaling pathway
GO:0040008 regulation of growth
GO:0043967 histone H4 acetylation
GO:0043968 histone H2A acetylation
Cellular Component
GO:0000812 Swr1 complex
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005739 mitochondrion
GO:0035267 NuA4 histone acetyltransferase complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000003778
View Gene Order
ENSBTAG00000008753
Not yet available
Pathways
NETPATH
REACTOME
REACT_172610
HATs acetylate histones pathway
REACT_172623
Chromatin organization pathway
REACT_172633
Chromatin modifying enzymes pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.519337
RefSeq NM_001164326 NM_001300961 NM_001300962 NM_001300966 NM_006696 NM_139199 XM_005271861 XM_005271864 XM_005271865 XM_006714525
HUGO
OMIM
CCDS CCDS34241 CCDS4198 CCDS54907
HPRD 04166
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca