InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: CDT1

Summary

InnateDB Gene

IDBG-46673.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CDT1

Gene Name

chromatin licensing and DNA replication factor 1

Synonyms

Species

Homo sapiens

Ensembl Gene

ENSG00000167513

Encoded Proteins

IDBP-46675

chromatin licensing and DNA replication factor 1

IDBP-752111

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The protein encoded by this gene is involved in the formation of the pre-replication complex that is necessary for DNA replication. The encoded protein can bind geminin, which prevents replication and may function to prevent this protein from initiating replication at inappropriate origins. Phosphorylation of this protein by cyclin A-dependent kinases results in degradation of the protein. [provided by RefSeq, Mar 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 16:88803213-88809258

Strand

Forward strand

Band

q24.3

Transcripts

ENST00000301019	ENSP00000301019
ENST00000562747
ENST00000569140	ENSP00000456926

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 75 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Experimentally validated
Total	75 [view]
Protein-Protein	75 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0005515	protein binding

Biological Process

GO:0000076	DNA replication checkpoint
GO:0000082	G1/S transition of mitotic cell cycle
GO:0000083	regulation of transcription involved in G1/S transition of mitotic cell cycle
GO:0000278	mitotic cell cycle
GO:0006260	DNA replication
GO:0030174	regulation of DNA-dependent DNA replication initiation
GO:0033262	regulation of nuclear cell cycle DNA replication