Version 5.4
Homo sapiens Gene: THRA
Summary
InnateDB Gene IDBG-47063.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol THRA
Gene Name thyroid hormone receptor, alpha
Synonyms AR7; c-ERBA-1; CHNG6; EAR7; ERB-T-1; ERBA; ERBA1; NR1A1; THRA1; THRA2
Species Homo sapiens
Ensembl Gene ENSG00000126351
Encoded Proteins
IDBP-47065
thyroid hormone receptor, alpha
IDBP-242230
thyroid hormone receptor, alpha
IDBP-377608
thyroid hormone receptor, alpha
IDBP-595393
thyroid hormone receptor, alpha
IDBP-762874
IDBP-763540
IDBP-760765
IDBP-758632
IDBP-758021
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a nuclear hormone receptor for triiodothyronine. It is one of the several receptors for thyroid hormone, and has been shown to mediate the biological activities of thyroid hormone. Knockout studies in mice suggest that the different receptors, while having certain extent of redundancy, may mediate different functions of thyroid hormone. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:40058290-40093867
Strand Forward strand
Band q21.1
Transcripts
ENST00000264637 ENSP00000264637
ENST00000394121 ENSP00000377679
ENST00000450525 ENSP00000395641
ENST00000546243 ENSP00000443972
ENST00000584985 ENSP00000463466
ENST00000578218 ENSP00000464123
ENST00000577486 ENSP00000464414
ENST00000585047 ENSP00000462955
ENST00000577288 ENSP00000464013
ENST00000577637
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 89 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Experimentally validated
Total 89 [view]
Protein-Protein 88 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 5 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0002153 steroid receptor RNA activator RNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0003707 steroid hormone receptor activity
GO:0003727 single-stranded RNA binding
GO:0004879 ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0004887 thyroid hormone receptor activity
GO:0005515 protein binding
GO:0008134 transcription factor binding
GO:0008270 zinc ion binding
GO:0017025 TBP-class protein binding
GO:0019904 protein domain specific binding
GO:0031490 chromatin DNA binding
GO:0032403 protein complex binding
GO:0043565 sequence-specific DNA binding
GO:0044212 transcription regulatory region DNA binding
GO:0070324 thyroid hormone binding
Biological Process
GO:0001502 cartilage condensation
GO:0001503 ossification
GO:0002155 regulation of thyroid hormone mediated signaling pathway
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006357 regulation of transcription from RNA polymerase II promoter
GO:0006366 transcription from RNA polymerase II promoter
GO:0006367 transcription initiation from RNA polymerase II promoter
GO:0007611 learning or memory
GO:0008016 regulation of heart contraction
GO:0008050 female courtship behavior
GO:0009409 response to cold
GO:0009755 hormone-mediated signaling pathway
GO:0009887 organ morphogenesis
GO:0010467 gene expression
GO:0010831 positive regulation of myotube differentiation
GO:0017055 negative regulation of RNA polymerase II transcriptional preinitiation complex assembly
GO:0030218 erythrocyte differentiation
GO:0030522 intracellular receptor signaling pathway
GO:0030878 thyroid gland development
GO:0033032 regulation of myeloid cell apoptotic process
GO:0042994 cytoplasmic sequestering of transcription factor
GO:0043401 steroid hormone mediated signaling pathway
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045925 positive regulation of female receptivity
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0050994 regulation of lipid catabolic process
GO:0060509 Type I pneumocyte differentiation
GO:2000143 negative regulation of DNA-dependent transcription, initiation
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005829 cytosol
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000058756
View Gene Order
ENSBTAG00000010745
Not yet available
Pathways
NETPATH
REACTOME
REACT_15525
Nuclear Receptor transcription pathway pathway
REACT_12627
Generic Transcription Pathway pathway
REACT_71
Gene Expression pathway
KEGG
hsa04080
Neuroactive ligand-receptor interaction pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_001190918 NM_001190919 NM_003250 NM_199334
HUGO
OMIM
CCDS CCDS11360 CCDS42316 CCDS58546
HPRD 07185
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca