Homo sapiens Gene: RARA
Summary
InnateDB Gene IDBG-47411.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol RARA
Gene Name retinoic acid receptor, alpha
Synonyms NR1B1; RAR;
Species Homo sapiens
Ensembl Gene ENSG00000131759
Encoded Proteins
retinoic acid receptor, alpha
retinoic acid receptor, alpha
retinoic acid receptor, alpha
retinoic acid receptor, alpha
retinoic acid receptor, alpha
retinoic acid receptor, alpha
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene represents a nuclear retinoic acid receptor. The encoded protein, retinoic acid receptor alpha, regulates transcription in a ligand-dependent manner. This gene has been implicated in regulation of development, differentiation, apoptosis, granulopoeisis, and transcription of clock genes. Translocations between this locus and several other loci have been associated with acute promyelocytic leukemia. Alternatively spliced transcript variants have been found for this locus.[provided by RefSeq, Sep 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:40309192-40357643
Strand Forward strand
Band q21.2
Transcripts
ENST00000254066 ENSP00000254066
ENST00000394089 ENSP00000377649
ENST00000394086 ENSP00000377648
ENST00000394081 ENSP00000377643
ENST00000425707 ENSP00000389993
ENST00000420042
ENST00000475125 ENSP00000462514
ENST00000582914
ENST00000577646 ENSP00000464287
ENST00000579727
ENST00000617726 ENSP00000478820
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 188 experimentally validated interaction(s) in this database.
They are also associated with 62 interaction(s) predicted by orthology.
Experimentally validated
Total 188 [view]
Protein-Protein 179 [view]
Protein-DNA 7 [view]
Protein-RNA 0
DNA-DNA 2 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 62 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000900 translation repressor activity, nucleic acid binding
GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding
GO:0001012 RNA polymerase II regulatory region DNA binding
GO:0001972 retinoic acid binding
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0003707 steroid hormone receptor activity
GO:0003708 retinoic acid receptor activity
GO:0003713 transcription coactivator activity
GO:0003714 transcription corepressor activity
GO:0004879 ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0005102 receptor binding
GO:0005515 protein binding
GO:0008134 transcription factor binding
GO:0008144 drug binding
GO:0008270 zinc ion binding
GO:0019899 enzyme binding
GO:0019904 protein domain specific binding
GO:0031490 chromatin DNA binding
GO:0035014 phosphatidylinositol 3-kinase regulator activity
GO:0043422 protein kinase B binding
GO:0043565 sequence-specific DNA binding
GO:0044212 transcription regulatory region DNA binding
GO:0044323 retinoic acid-responsive element binding
GO:0046982 protein heterodimerization activity
GO:0048027 mRNA 5'-UTR binding
GO:0051018 protein kinase A binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0001657 ureteric bud development
GO:0001843 neural tube closure
GO:0001889 liver development
GO:0002068 glandular epithelial cell development
GO:0003148 outflow tract septum morphogenesis
GO:0003417 growth plate cartilage development
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006367 transcription initiation from RNA polymerase II promoter
GO:0006468 protein phosphorylation
GO:0007165 signal transduction
GO:0007281 germ cell development
GO:0007283 spermatogenesis
GO:0007565 female pregnancy
GO:0008284 positive regulation of cell proliferation
GO:0008285 negative regulation of cell proliferation
GO:0008584 male gonad development
GO:0010467 gene expression
GO:0010628 positive regulation of gene expression
GO:0010629 negative regulation of gene expression
GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling
GO:0017148 negative regulation of translation
GO:0030520 intracellular estrogen receptor signaling pathway
GO:0030850 prostate gland development
GO:0030852 regulation of granulocyte differentiation
GO:0030853 negative regulation of granulocyte differentiation
GO:0031076 embryonic camera-type eye development
GO:0031641 regulation of myelination
GO:0032355 response to estradiol
GO:0032526 response to retinoic acid
GO:0032689 negative regulation of interferon-gamma production
GO:0032720 negative regulation of tumor necrosis factor production
GO:0032736 positive regulation of interleukin-13 production
GO:0032753 positive regulation of interleukin-4 production
GO:0032754 positive regulation of interleukin-5 production
GO:0033189 response to vitamin A
GO:0034097 response to cytokine
GO:0035264 multicellular organism growth
GO:0042981 regulation of apoptotic process
GO:0043066 negative regulation of apoptotic process
GO:0043277 apoptotic cell clearance
GO:0043401 steroid hormone mediated signaling pathway
GO:0043551 regulation of phosphatidylinositol 3-kinase activity
GO:0045471 response to ethanol
GO:0045596 negative regulation of cell differentiation
GO:0045630 positive regulation of T-helper 2 cell differentiation
GO:0045666 positive regulation of neuron differentiation
GO:0045787 positive regulation of cell cycle
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0045947 negative regulation of translational initiation
GO:0048167 regulation of synaptic plasticity
GO:0048384 retinoic acid receptor signaling pathway
GO:0051099 positive regulation of binding
GO:0051897 positive regulation of protein kinase B signaling
GO:0055012 ventricular cardiac muscle cell differentiation
GO:0060010 Sertoli cell fate commitment
GO:0060173 limb development
GO:0060324 face development
GO:0060348 bone development
GO:0060534 trachea cartilage development
GO:0060591 chondroblast differentiation
GO:0061037 negative regulation of cartilage development
GO:0070374 positive regulation of ERK1 and ERK2 cascade
GO:0071222 cellular response to lipopolysaccharide
GO:0071300 cellular response to retinoic acid
GO:0071391 cellular response to estrogen stimulus
Cellular Component
GO:0000790 nuclear chromatin
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0009986 cell surface
GO:0030425 dendrite
GO:0043005 neuron projection
GO:0043025 neuronal cell body
GO:0048471 perinuclear region of cytoplasm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
IL3 pathway
FSH pathway
REACTOME
Nuclear Receptor transcription pathway pathway
Generic Transcription Pathway pathway
Gene Expression pathway
KEGG
Pathways in cancer pathway
Acute myeloid leukemia pathway
INOH
PID BIOCARTA
Nuclear receptors coordinate the activities of chromatin remodeling complexes and coactivators to facilitate initiation of transcription in carcinoma cells [Biocarta view]
Map kinase inactivation of smrt corepressor [Biocarta view]
Transcription regulation by methyltransferase of carm1 [Biocarta view]
Degradation of the rar and rxr by the proteasome [Biocarta view]
PID NCI
Retinoic acid receptors-mediated signaling
Cross-References
SwissProt P10276
TrEMBL F1D8N9 J3KSJ4
UniProt Splice Variant
Entrez Gene 5914
UniGene Hs.654583
RefSeq NM_001024809 NM_000964 NM_001145301 NM_001145302 XM_005257552 XM_005257553 XM_005257555 XM_005257554
HUGO HGNC:9864
OMIM 180240
CCDS CCDS42317 CCDS11366 CCDS45671
HPRD 06769
IMGT
EMBL AB067754 AC080112 AF088889 AF088890 AF088891 AF088892 AF088893 AF088894 AF088895 AF283809 BC008727 BC071733 CH471152 FJ487576 HQ692827 U41742 U41743 X06538 X06614 X56058 X58685
GenPept AAB00112 AAB00113 AAD05222 AAF87249 AAH08727 AAH71733 ACK86665 ADZ17338 BAB62809 CAA29787 CAA29829 CAA39533 CAA41532 EAW60653
RNA Seq Atlas 5914