Homo sapiens Gene: CDK10
Summary
InnateDB Gene IDBG-47912.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CDK10
Gene Name cyclin-dependent kinase 10
Synonyms PISSLRE;
Species Homo sapiens
Ensembl Gene ENSG00000185324
Encoded Proteins
cyclin-dependent kinase 10
cyclin-dependent kinase 10
cyclin-dependent kinase 10
cyclin-dependent kinase 10
cyclin-dependent kinase 10
cyclin-dependent kinase 10
cyclin-dependent kinase 10
cyclin-dependent kinase 10
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene belongs to the CDK subfamily of the Ser/Thr protein kinase family. The CDK subfamily members are highly similar to the gene products of S. cerevisiae cdc28, and S. pombe cdc2, and are known to be essential for cell cycle progression. This kinase has been shown to play a role in cellular proliferation and its function is limited to cell cycle G2-M phase. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 16:89680737-89696364
Strand Forward strand
Band q24.3
Transcripts
ENST00000353379 ENSP00000338673
ENST00000331006 ENSP00000329957
ENST00000378277
ENST00000505473 ENSP00000424415
ENST00000510811 ENSP00000455976
ENST00000508723 ENSP00000423370
ENST00000511415 ENSP00000426102
ENST00000502547 ENSP00000421597
ENST00000505733
ENST00000512912 ENSP00000426264
ENST00000507205
ENST00000472018
ENST00000514965
ENST00000503560
ENST00000504473
ENST00000564192 ENSP00000457055
ENST00000561477
ENST00000568456
ENST00000565470 ENSP00000456788
ENST00000567932
ENST00000617879 ENSP00000484357
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
Experimentally validated
Total 10 [view]
Protein-Protein 10 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004693 cyclin-dependent protein serine/threonine kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016301 kinase activity
GO:0016772 transferase activity, transferring phosphorus-containing groups
Biological Process
GO:0006468 protein phosphorylation
GO:0007089 traversing start control point of mitotic cell cycle
GO:0008285 negative regulation of cell proliferation
GO:0016310 phosphorylation
Cellular Component
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Not yet available
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Cross-References
SwissProt
TrEMBL D6REZ2
UniProt Splice Variant
Entrez Gene 8558
UniGene Hs.699177
RefSeq NM_001098533 NM_001160367 NM_052987 NM_052988 XM_006721308 XM_006721309 XM_006721310 XM_006721312 XM_006721313 XM_006721314 XM_006721315 XM_006721316 XM_006721317
HUGO HGNC:1770
OMIM 603464
CCDS CCDS10984 CCDS32514
HPRD
IMGT
EMBL AC010538
GenPept
RNA Seq Atlas 8558