InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: NOS3

Summary

InnateDB Gene

IDBG-48571.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

NOS3

Gene Name

nitric oxide synthase 3 (endothelial cell)

Synonyms

ECNOS; eNOS

Species

Homo sapiens

Ensembl Gene

ENSG00000164867

Encoded Proteins

IDBP-48573

nitric oxide synthase 3 (endothelial cell)

IDBP-473364

nitric oxide synthase 3 (endothelial cell)

IDBP-476620

nitric oxide synthase 3 (endothelial cell)

IDBP-479143

nitric oxide synthase 3 (endothelial cell)

IDBP-480481

nitric oxide synthase 3 (endothelial cell)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

Nitric oxide is a reactive free radical which acts as a biologic mediator in several processes, including neurotransmission and antimicrobial and antitumoral activities. Nitric oxide is synthesized from L-arginine by nitric oxide synthases. Variations in this gene are associated with susceptibility to coronary spasm. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2009]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 7:150990995-151014588

Strand

Forward strand

Band

q36.1

Transcripts

ENST00000297494	ENSP00000297494
ENST00000461406	ENSP00000417143
ENST00000484524	ENSP00000420215
ENST00000467517	ENSP00000420551
ENST00000460603
ENST00000473057
ENST00000475017	ENSP00000418245
ENST00000468293
ENST00000477227
ENST00000498521
ENST00000475454

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 69 experimentally validated interaction(s) in this database.

Experimentally validated
Total	69 [view]
Protein-Protein	69 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003785	actin monomer binding
GO:0003958	NADPH-hemoprotein reductase activity
GO:0004517	nitric-oxide synthase activity
GO:0005506	iron ion binding
GO:0005515	protein binding
GO:0005516	calmodulin binding
GO:0010181	FMN binding
GO:0016491	oxidoreductase activity
GO:0020037	heme binding
GO:0034617	tetrahydrobiopterin binding
GO:0034618	arginine binding
GO:0046870	cadmium ion binding
GO:0050660	flavin adenine dinucleotide binding
GO:0050661	NADP binding

Biological Process

GO:0001525	angiogenesis
GO:0001542	ovulation from ovarian follicle
GO:0001701	in utero embryonic development
GO:0001974	blood vessel remodeling
GO:0002028	regulation of sodium ion transport
GO:0003057	regulation of the force of heart contraction by chemical signal
GO:0003100	regulation of systemic arterial blood pressure by endothelin
GO:0006527	arginine catabolic process
GO:0006809	nitric oxide biosynthetic process
GO:0007005	mitochondrion organization
GO:0007263	nitric oxide mediated signal transduction
GO:0007596	blood coagulation
GO:0008217	regulation of blood pressure
GO:0008285	negative regulation of cell proliferation
GO:0009408	response to heat
GO:0010544	negative regulation of platelet activation
GO:0014740	negative regulation of muscle hyperplasia
GO:0014806	smooth muscle hyperplasia
GO:0030324	lung development
GO:0031284	positive regulation of guanylate cyclase activity
GO:0031663	lipopolysaccharide-mediated signaling pathway
GO:0034405	response to fluid shear stress
GO:0043267	negative regulation of potassium ion transport
GO:0043542	endothelial cell migration
GO:0044281	small molecule metabolic process
GO:0045766	positive regulation of angiogenesis
GO:0045776	negative regulation of blood pressure
GO:0045909	positive regulation of vasodilation
GO:0046209	nitric oxide metabolic process
GO:0050880	regulation of blood vessel size
GO:0050999	regulation of nitric-oxide synthase activity
GO:0051346	negative regulation of hydrolase activity
GO:0051701	interaction with host
GO:0051926	negative regulation of calcium ion transport
GO:0055114	oxidation-reduction process
GO:0090382	phagosome maturation
GO:1902042	negative regulation of extrinsic apoptotic signaling pathway via death domain receptors

Cellular Component

GO:0000139	Golgi membrane
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005856	cytoskeleton
GO:0005886	plasma membrane
GO:0005901	caveola
GO:0030666	endocytic vesicle membrane