Homo sapiens Gene: NOS3
Summary
InnateDB Gene IDBG-48571.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol NOS3
Gene Name nitric oxide synthase 3 (endothelial cell)
Synonyms ECNOS; eNOS;
Species Homo sapiens
Ensembl Gene ENSG00000164867
Encoded Proteins
nitric oxide synthase 3 (endothelial cell)
nitric oxide synthase 3 (endothelial cell)
nitric oxide synthase 3 (endothelial cell)
nitric oxide synthase 3 (endothelial cell)
nitric oxide synthase 3 (endothelial cell)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Nitric oxide is a reactive free radical which acts as a biologic mediator in several processes, including neurotransmission and antimicrobial and antitumoral activities. Nitric oxide is synthesized from L-arginine by nitric oxide synthases. Variations in this gene are associated with susceptibility to coronary spasm. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:150990995-151014588
Strand Forward strand
Band q36.1
Transcripts
ENST00000297494 ENSP00000297494
ENST00000461406 ENSP00000417143
ENST00000484524 ENSP00000420215
ENST00000467517 ENSP00000420551
ENST00000460603
ENST00000473057
ENST00000475017 ENSP00000418245
ENST00000468293
ENST00000477227
ENST00000498521
ENST00000475454
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 69 experimentally validated interaction(s) in this database.
Experimentally validated
Total 69 [view]
Protein-Protein 69 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003785 actin monomer binding
GO:0003958 NADPH-hemoprotein reductase activity
GO:0004517 nitric-oxide synthase activity
GO:0005506 iron ion binding
GO:0005515 protein binding
GO:0005516 calmodulin binding
GO:0010181 FMN binding
GO:0016491 oxidoreductase activity
GO:0020037 heme binding
GO:0034617 tetrahydrobiopterin binding
GO:0034618 arginine binding
GO:0046870 cadmium ion binding
GO:0050660 flavin adenine dinucleotide binding
GO:0050661 NADP binding
Biological Process
GO:0001525 angiogenesis
GO:0001542 ovulation from ovarian follicle
GO:0001701 in utero embryonic development
GO:0001974 blood vessel remodeling
GO:0002028 regulation of sodium ion transport
GO:0003057 regulation of the force of heart contraction by chemical signal
GO:0003100 regulation of systemic arterial blood pressure by endothelin
GO:0006527 arginine catabolic process
GO:0006809 nitric oxide biosynthetic process
GO:0007005 mitochondrion organization
GO:0007263 nitric oxide mediated signal transduction
GO:0007596 blood coagulation
GO:0008217 regulation of blood pressure
GO:0008285 negative regulation of cell proliferation
GO:0009408 response to heat
GO:0010544 negative regulation of platelet activation
GO:0014740 negative regulation of muscle hyperplasia
GO:0014806 smooth muscle hyperplasia
GO:0030324 lung development
GO:0031284 positive regulation of guanylate cyclase activity
GO:0031663 lipopolysaccharide-mediated signaling pathway
GO:0034405 response to fluid shear stress
GO:0043267 negative regulation of potassium ion transport
GO:0043542 endothelial cell migration
GO:0044281 small molecule metabolic process
GO:0045766 positive regulation of angiogenesis
GO:0045776 negative regulation of blood pressure
GO:0045909 positive regulation of vasodilation
GO:0046209 nitric oxide metabolic process
GO:0050880 regulation of blood vessel size
GO:0050999 regulation of nitric-oxide synthase activity
GO:0051346 negative regulation of hydrolase activity
GO:0051701 interaction with host
GO:0051926 negative regulation of calcium ion transport
GO:0055114 oxidation-reduction process
GO:0090382 phagosome maturation
GO:1902042 negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
Cellular Component
GO:0000139 Golgi membrane
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005856 cytoskeleton
GO:0005886 plasma membrane
GO:0005901 caveola
GO:0030666 endocytic vesicle membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
EGFR1 pathway
Leptin pathway
REACTOME
eNOS activation and regulation pathway
Signaling by VEGF pathway
Metabolism of nitric oxide pathway
VEGFR2 mediated vascular permeability pathway
Signal Transduction pathway
Phagosomal maturation (early endosomal stage) pathway
Platelet homeostasis pathway
NOSTRIN mediated eNOS trafficking pathway
VEGFA-VEGFR2 Pathway pathway
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation pathway
Metabolism pathway
Latent infection of Homo sapiens with Mycobacterium tuberculosis pathway
Disease pathway
Hemostasis pathway
NOSIP mediated eNOS trafficking pathway
Nitric oxide stimulates guanylate cyclase pathway
eNOS activation pathway
KEGG
Arginine and proline metabolism pathway
Calcium signaling pathway pathway
VEGF signaling pathway pathway
INOH
Arginine Proline metabolism pathway
PID BIOCARTA
Hypoxia-inducible factor in the cardivascular system [Biocarta view]
Corticosteroids and cardioprotection [Biocarta view]
Vegf hypoxia and angiogenesis [Biocarta view]
Actions of nitric oxide in the heart [Biocarta view]
Ion channels and their functional role in vascular endothelium [Biocarta view]
PID NCI
Thromboxane A2 receptor signaling
Validated transcriptional targets of AP1 family members Fra1 and Fra2
PAR1-mediated thrombin signaling events
Angiopoietin receptor Tie2-mediated signaling
Signaling events mediated by VEGFR1 and VEGFR2
Plasma membrane estrogen receptor signaling
SHP2 signaling
VEGFR1 specific signals
Cross-References
SwissProt
TrEMBL E7ESA7 Q96P37
UniProt Splice Variant
Entrez Gene 4846
UniGene Hs.647092 Hs.692513 Hs.716846
RefSeq NM_000603 NM_001160111 NM_001160110 NM_001160109 XM_006716001 XM_006716000 NM_173681
HUGO HGNC:7876
OMIM 163729
CCDS CCDS5912 CCDS55182 CCDS55183
HPRD 01224
IMGT
EMBL AC010973 AF415200
GenPept AAL07497
RNA Seq Atlas 4846