Version 5.4
Mus musculus Gene: Cdk5r2
Summary
InnateDB Gene IDBG-486630.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Cdk5r2
Gene Name cyclin-dependent kinase 5, regulatory subunit 2 (p39)
Synonyms B230310J22Rik; p39
Species Mus musculus
Ensembl Gene ENSMUSG00000090071
Encoded Proteins
IDBP-537127
cyclin-dependent kinase 5, regulatory subunit 2 (p39)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000171450:
The protein encoded by this gene is a neuron-specific activator of CDK5 kinase. It associates with CDK5 to form an active kinase. This protein and neuron-specific CDK5 activator CDK5R1/p39NCK5A both share limited similarity to cyclins, and thus may define a distinct family of cyclin-dependent kinase activating proteins. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:74854934-74857732
Strand Forward strand
Band C4
Transcripts
ENSMUST00000160379 ENSMUSP00000125322
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0008092 cytoskeletal protein binding
GO:0008289 lipid binding
GO:0016534 cyclin-dependent protein kinase 5 activator activity
Biological Process
GO:0001764 neuron migration
GO:0021549 cerebellum development
GO:0021722 superior olivary nucleus maturation
GO:0021766 hippocampus development
GO:0021819 layer formation in cerebral cortex
GO:0045860 positive regulation of protein kinase activity
GO:0045956 positive regulation of calcium ion-dependent exocytosis
GO:0071902 positive regulation of protein serine/threonine kinase activity
Cellular Component
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0016533 cyclin-dependent protein kinase 5 holoenzyme complex
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000171450
View Gene Order
ENSBTAG00000031052
Not yet available
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
INOH
PID NCI
lis1pathway
Lissencephaly gene (LIS1) in neuronal migration and development
Cross-References
SwissProt O35926
TrEMBL
UniProt Splice Variant
Entrez Gene 12570
UniGene Mm.153833 Mm.397577
RefSeq NM_009872
OMIM
CCDS CCDS48290
HPRD
IMGT
MGI ID MGI:1330828
MGI Symbol Cdk5r2
EMBL AF016393 AF071086 CH466548 U90267
GenPept AAB69709 AAC53595 AAF14854 EDL00353
RNA Seq Atlas 12570

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca