Homo sapiens Gene: CD47
Summary
InnateDB Gene IDBG-48744.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CD47
Gene Name CD47 molecule
Synonyms IAP; MER6; OA3;
Species Homo sapiens
Ensembl Gene ENSG00000196776
Encoded Proteins
CD47 molecule
CD47 molecule
CD47 molecule
CD47 molecule
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation from Orthologs
Summary
[Mus musculus] Cd47 plays a protective role against disseminated candidiasis and alters pro-inflammatory and immunosuppressive pathways known to regulate innate and T cell immunity.
[Mus musculus] Cd47 plays a role as a negative regulator in inducing protective immune responses to influenza vaccination.
Entrez Gene
Summary This gene encodes a membrane protein, which is involved in the increase in intracellular calcium concentration that occurs upon cell adhesion to extracellular matrix. The encoded protein is also a receptor for the C-terminal cell binding domain of thrombospondin, and it may play a role in membrane transport and signal transduction. This gene has broad tissue distribution, and is reduced in expression on Rh erythrocytes. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:108043298-108091025
Strand Reverse strand
Band q13.12
Transcripts
ENST00000355354 ENSP00000347512
ENST00000361309 ENSP00000355361
ENST00000398258 ENSP00000381309
ENST00000471694
ENST00000517766 ENSP00000430843
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 9 [view]
Protein-Protein 9 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0070053 thrombospondin receptor activity
Biological Process
GO:0007155 cell adhesion
GO:0007229 integrin-mediated signaling pathway
GO:0007596 blood coagulation
GO:0008228 opsonization
GO:0008284 positive regulation of cell proliferation
GO:0009617 response to bacterium
GO:0022409 positive regulation of cell-cell adhesion
GO:0030198 extracellular matrix organization
GO:0050729 positive regulation of inflammatory response
GO:0050766 positive regulation of phagocytosis
GO:0050870 positive regulation of T cell activation
GO:0050900 leukocyte migration
Cellular Component
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Cell-Cell communication pathway
Extracellular matrix organization pathway
Signal regulatory protein (SIRP) family interactions pathway
Integrin cell surface interactions pathway
Cell surface interactions at the vascular wall pathway
Hemostasis pathway
KEGG
ECM-receptor interaction pathway
INOH
PID BIOCARTA
PID NCI
Beta3 integrin cell surface interactions
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.674188 Hs.702403 Hs.713993
RefSeq NM_001777 NM_198793
HUGO
OMIM
CCDS CCDS43125 CCDS43126
HPRD 03017
IMGT
EMBL
GenPept
RNA Seq Atlas