|Homo sapiens Gene: CD47|
|Last Modified||2014-10-13 [Report errors or provide feedback]|
|Gene Name||CD47 molecule|
|Synonyms||IAP; MER6; OA3;|
|Useful resources||Stemformatics EHFPI ImmGen|
|InnateDB Annotation from Orthologs|
[Mus musculus] Cd47 plays a protective role against disseminated candidiasis and alters pro-inflammatory and immunosuppressive pathways known to regulate innate and T cell immunity.
[Mus musculus] Cd47 plays a role as a negative regulator in inducing protective immune responses to influenza vaccination.
This gene encodes a membrane protein, which is involved in the increase in intracellular calcium concentration that occurs upon cell adhesion to extracellular matrix. The encoded protein is also a receptor for the C-terminal cell binding domain of thrombospondin, and it may play a role in membrane transport and signal transduction. This gene has broad tissue distribution, and is reduced in expression on Rh erythrocytes. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2010]
|Genomic Location||Chromosome 3:108043298-108091025|
|Number of Interactions||
This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Cell-Cell communication pathway
Extracellular matrix organization pathway
Signal regulatory protein (SIRP) family interactions pathway
Integrin cell surface interactions pathway
Cell surface interactions at the vascular wall pathway
ECM-receptor interaction pathway
Beta3 integrin cell surface interactions
|UniProt Splice Variant|
|UniGene||Hs.674188 Hs.702403 Hs.713993|
|RNA Seq Atlas|