Version 5.4
Homo sapiens Gene: MS4A2
Summary
InnateDB Gene IDBG-48886.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MS4A2
Gene Name membrane-spanning 4-domains, subfamily A, member 2
Synonyms APY; ATOPY; FCER1B; FCERI; IGEL; IGER; IGHER; MS4A1
Species Homo sapiens
Ensembl Gene ENSG00000149534
Encoded Proteins
IDBP-48888
membrane-spanning 4-domains, subfamily A, member 2 (Fc fragment of IgE, high affinity I, receptor for; beta polypeptide)
IDBP-584109
membrane-spanning 4-domains, subfamily A, member 2 (Fc fragment of IgE, high affinity I, receptor for; beta polypeptide)
IDBP-809052
membrane-spanning 4-domains, subfamily A, member 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The allergic response involves the binding of allergen to receptor-bound IgE followed by cell activation and the release of mediators responsible for the manifestations of allergy. The IgE-receptor, a tetramer composed of an alpha, beta, and 2 disulfide-linked gamma chains, is found on the surface of mast cells and basophils. This gene encodes the beta subunit of the high affinity IgE receptor which is a member of the membrane-spanning 4A gene family. Members of this nascent protein family are characterized by common structural features and similar intron/exon splice boundaries and display unique expression patterns among hematopoietic cells and nonlymphoid tissues. This family member is localized to 11q12, among a cluster of membrane-spanning 4A gene family members. Alternative splicing results in multiple transcript variants encoding distinct proteins. Additional transcript variants have been described but require experimental validation. [provided by RefSeq, Mar 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:60088261-60098466
Strand Forward strand
Band q12.1
Transcripts
ENST00000278888 ENSP00000278888
ENST00000440896
ENST00000524868 ENSP00000433311
ENST00000617306 ENSP00000482594
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 26 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
Experimentally validated
Total 26 [view]
Protein-Protein 22 [view]
Protein-DNA 4 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 6 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0019767 IgE receptor activity
GO:0019863 IgE binding
GO:0019901 protein kinase binding
GO:0042169 SH2 domain binding
GO:0051219 phosphoprotein binding
Biological Process
GO:0006954 inflammatory response
GO:0006955 immune response
GO:0007165 signal transduction
GO:0007166 cell surface receptor signaling pathway
GO:0007202 activation of phospholipase C activity
GO:0007205 protein kinase C-activating G-protein coupled receptor signaling pathway
GO:0038095 Fc-epsilon receptor signaling pathway
GO:0043306 positive regulation of mast cell degranulation
GO:0045087 innate immune response
GO:0050663 cytokine secretion
GO:0051279 regulation of release of sequestered calcium ion into cytosol
Cellular Component
GO:0005768 endosome
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0009897 external side of plasma membrane
GO:0016021 integral component of membrane
GO:0032998 Fc-epsilon receptor I complex
GO:0045121 membrane raft
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000024680
View Gene Order
ENSBTAG00000020096
Not yet available
Pathways
NETPATH
REACTOME
REACT_163994
FCERI mediated NF-kB activation pathway
REACT_163769
Role of LAT2/NTAL/LAB on calcium mobilization pathway
REACT_6802
Innate Immune System pathway
REACT_163936
Fc epsilon receptor (FCERI) signaling pathway
REACT_6900
Immune System pathway
REACT_163834
FCERI mediated Ca+2 mobilization pathway
REACT_163701
FCERI mediated MAPK activation pathway
KEGG
hsa04664
Fc epsilon RI signaling pathway pathway
hsa05310
Asthma pathway
INOH
PID NCI
fcer1pathway
Fc-epsilon receptor I signaling in mast cells
Cross-References
SwissProt
TrEMBL E9PLJ1
UniProt Splice Variant
Entrez Gene 2206
UniGene
RefSeq NM_001256916 NM_000139
HUGO HGNC:7316
OMIM 147138
CCDS CCDS73292 CCDS7980
HPRD
IMGT
EMBL AP001181
GenPept
RNA Seq Atlas 2206

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca