Homo sapiens Gene: MS4A2
Summary
InnateDB Gene IDBG-48886.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MS4A2
Gene Name membrane-spanning 4-domains, subfamily A, member 2
Synonyms APY; ATOPY; FCER1B; FCERI; IGEL; IGER; IGHER; MS4A1;
Species Homo sapiens
Ensembl Gene ENSG00000149534
Encoded Proteins
membrane-spanning 4-domains, subfamily A, member 2 (Fc fragment of IgE, high affinity I, receptor for; beta polypeptide)
membrane-spanning 4-domains, subfamily A, member 2 (Fc fragment of IgE, high affinity I, receptor for; beta polypeptide)
membrane-spanning 4-domains, subfamily A, member 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The allergic response involves the binding of allergen to receptor-bound IgE followed by cell activation and the release of mediators responsible for the manifestations of allergy. The IgE-receptor, a tetramer composed of an alpha, beta, and 2 disulfide-linked gamma chains, is found on the surface of mast cells and basophils. This gene encodes the beta subunit of the high affinity IgE receptor which is a member of the membrane-spanning 4A gene family. Members of this nascent protein family are characterized by common structural features and similar intron/exon splice boundaries and display unique expression patterns among hematopoietic cells and nonlymphoid tissues. This family member is localized to 11q12, among a cluster of membrane-spanning 4A gene family members. Alternative splicing results in multiple transcript variants encoding distinct proteins. Additional transcript variants have been described but require experimental validation. [provided by RefSeq, Mar 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:60088261-60098466
Strand Forward strand
Band q12.1
Transcripts
ENST00000278888 ENSP00000278888
ENST00000440896
ENST00000524868 ENSP00000433311
ENST00000617306 ENSP00000482594
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 26 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
Experimentally validated
Total 26 [view]
Protein-Protein 22 [view]
Protein-DNA 4 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 6 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0019767 IgE receptor activity
GO:0019863 IgE binding
GO:0019901 protein kinase binding
GO:0042169 SH2 domain binding
GO:0051219 phosphoprotein binding
Biological Process
GO:0006954 inflammatory response
GO:0006955 immune response
GO:0007165 signal transduction
GO:0007166 cell surface receptor signaling pathway
GO:0007202 activation of phospholipase C activity
GO:0007205 protein kinase C-activating G-protein coupled receptor signaling pathway
GO:0038095 Fc-epsilon receptor signaling pathway
GO:0043306 positive regulation of mast cell degranulation
GO:0045087 innate immune response
GO:0050663 cytokine secretion
GO:0051279 regulation of release of sequestered calcium ion into cytosol
Cellular Component
GO:0005768 endosome
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0009897 external side of plasma membrane
GO:0016021 integral component of membrane
GO:0032998 Fc-epsilon receptor I complex
GO:0045121 membrane raft
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Not yet available
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Pathways
NETPATH
REACTOME
FCERI mediated NF-kB activation pathway
Role of LAT2/NTAL/LAB on calcium mobilization pathway
Innate Immune System pathway
Fc epsilon receptor (FCERI) signaling pathway
Immune System pathway
FCERI mediated Ca+2 mobilization pathway
FCERI mediated MAPK activation pathway
KEGG
Fc epsilon RI signaling pathway pathway
Asthma pathway
INOH
PID BIOCARTA
Fc epsilon receptor i signaling in mast cells [Biocarta view]
PID NCI
Fc-epsilon receptor I signaling in mast cells
Cross-References
SwissProt
TrEMBL E9PLJ1
UniProt Splice Variant
Entrez Gene 2206
UniGene
RefSeq NM_001256916 NM_000139
HUGO HGNC:7316
OMIM 147138
CCDS CCDS73292 CCDS7980
HPRD
IMGT
EMBL AP001181
GenPept
RNA Seq Atlas 2206