Homo sapiens Gene: CDK5
Summary
InnateDB Gene IDBG-48977.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CDK5
Gene Name cyclin-dependent kinase 5
Synonyms PSSALRE;
Species Homo sapiens
Ensembl Gene ENSG00000164885
Encoded Proteins
cyclin-dependent kinase 5
cyclin-dependent kinase 5
cyclin-dependent kinase 5
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.
Gene Information
Type Protein coding
Genomic Location Chromosome 7:151053812-151058530
Strand Reverse strand
Band q36.1
Transcripts
ENST00000297518 ENSP00000297518
ENST00000485972 ENSP00000419782
ENST00000487703
ENST00000476691
ENST00000469108
ENST00000618146 ENSP00000481070
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 98 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.
Experimentally validated
Total 98 [view]
Protein-Protein 97 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 9 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0002039 p53 binding
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004693 cyclin-dependent protein serine/threonine kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005176 ErbB-2 class receptor binding
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0008092 cytoskeletal protein binding
GO:0016301 kinase activity
GO:0016772 transferase activity, transferring phosphorus-containing groups
GO:0030549 acetylcholine receptor activator activity
GO:0043125 ErbB-3 class receptor binding
GO:0046875 ephrin receptor binding
GO:0050321 tau-protein kinase activity
Biological Process
GO:0001764 neuron migration
GO:0001963 synaptic transmission, dopaminergic
GO:0006468 protein phosphorylation
GO:0006886 intracellular protein transport
GO:0006887 exocytosis
GO:0006913 nucleocytoplasmic transport
GO:0006915 apoptotic process
GO:0007049 cell cycle
GO:0007160 cell-matrix adhesion
GO:0007268 synaptic transmission
GO:0007409 axonogenesis
GO:0007411 axon guidance
GO:0007416 synapse assembly
GO:0007519 skeletal muscle tissue development
GO:0007596 blood coagulation
GO:0008045 motor neuron axon guidance
GO:0008283 cell proliferation
GO:0008306 associative learning
GO:0008542 visual learning
GO:0009611 response to wounding
GO:0009790 embryo development
GO:0014044 Schwann cell development
GO:0016079 synaptic vesicle exocytosis
GO:0016310 phosphorylation
GO:0016477 cell migration
GO:0018105 peptidyl-serine phosphorylation
GO:0018107 peptidyl-threonine phosphorylation
GO:0019233 sensory perception of pain
GO:0021537 telencephalon development
GO:0021549 cerebellum development
GO:0021695 cerebellar cortex development
GO:0021697 cerebellar cortex formation
GO:0021766 hippocampus development
GO:0021819 layer formation in cerebral cortex
GO:0021954 central nervous system neuron development
GO:0021987 cerebral cortex development
GO:0022038 corpus callosum development
GO:0030182 neuron differentiation
GO:0030334 regulation of cell migration
GO:0030517 negative regulation of axon extension
GO:0030866 cortical actin cytoskeleton organization
GO:0030900 forebrain development
GO:0031175 neuron projection development
GO:0031397 negative regulation of protein ubiquitination
GO:0031914 negative regulation of synaptic plasticity
GO:0032092 positive regulation of protein binding
GO:0032801 receptor catabolic process
GO:0033136 serine phosphorylation of STAT3 protein
GO:0035249 synaptic transmission, glutamatergic
GO:0035418 protein localization to synapse
GO:0042220 response to cocaine
GO:0042981 regulation of apoptotic process
GO:0043113 receptor clustering
GO:0043525 positive regulation of neuron apoptotic process
GO:0045055 regulated secretory pathway
GO:0045786 negative regulation of cell cycle
GO:0045860 positive regulation of protein kinase activity
GO:0045861 negative regulation of proteolysis
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045956 positive regulation of calcium ion-dependent exocytosis
GO:0046777 protein autophosphorylation
GO:0046826 negative regulation of protein export from nucleus
GO:0048148 behavioral response to cocaine
GO:0048167 regulation of synaptic plasticity
GO:0048488 synaptic vesicle endocytosis
GO:0048511 rhythmic process
GO:0048675 axon extension
GO:0048709 oligodendrocyte differentiation
GO:0048812 neuron projection morphogenesis
GO:0048813 dendrite morphogenesis
GO:0051301 cell division
GO:0051402 neuron apoptotic process
GO:0060078 regulation of postsynaptic membrane potential
GO:0060079 regulation of excitatory postsynaptic membrane potential
GO:0061001 regulation of dendritic spine morphogenesis
GO:0070509 calcium ion import
GO:0071156 regulation of cell cycle arrest
GO:0090314 positive regulation of protein targeting to membrane
GO:1901215 negative regulation of neuron death
GO:2000251 positive regulation of actin cytoskeleton reorganization
GO:2000273 positive regulation of receptor activity
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005856 cytoskeleton
GO:0014069 postsynaptic density
GO:0016020 membrane
GO:0016533 cyclin-dependent protein kinase 5 holoenzyme complex
GO:0030027 lamellipodium
GO:0030054 cell junction
GO:0030175 filopodium
GO:0030424 axon
GO:0030425 dendrite
GO:0030426 growth cone
GO:0031594 neuromuscular junction
GO:0043025 neuronal cell body
GO:0043204 perikaryon
GO:0045211 postsynaptic membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
AndrogenReceptor pathway
EGFR1 pathway
TNFalpha pathway
IL6 pathway
Leptin pathway
REACTOME
Developmental Biology pathway
Semaphorin interactions pathway
Signaling by GPCR pathway
Axon guidance pathway
CRMPs in Sema3A signaling pathway
Opioid Signalling pathway
Signal Transduction pathway
Factors involved in megakaryocyte development and platelet production pathway
DARPP-32 events pathway
Hemostasis pathway
KEGG
Axon guidance pathway
Alzheimer's disease pathway
INOH
IL-7 signaling pathway
JAK STAT pathway and regulation pathway
EPO signaling pathway pathway
VEGF signaling pathway pathway
GPCR Dopamine D1like receptor signaling pathway pathway
PID BIOCARTA
Fosb gene expression and drug abuse [Biocarta view]
Lissencephaly gene (lis1) in neuronal migration and development [Biocarta view]
Deregulation of cdk5 in alzheimers disease [Biocarta view]
Estrogen responsive protein efp controls cell cycle and breast tumors growth [Biocarta view]
Regulation of ck1/cdk5 by type 1 glutamate receptors [Biocarta view]
Phosphorylation of mek1 by cdk5/p35 down regulates the map kinase pathway [Biocarta view]
Rac1 cell motility signaling pathway [Biocarta view]
Bioactive peptide induced signaling pathway [Biocarta view]
PID NCI
EPHA forward signaling
Trk receptor signaling mediated by the MAPK pathway
Reelin signaling pathway
Glucocorticoid receptor regulatory network
Lissencephaly gene (LIS1) in neuronal migration and development
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_001164410 NM_004935
HUGO
OMIM
CCDS CCDS47748 CCDS55184
HPRD 00449
IMGT
EMBL
GenPept
RNA Seq Atlas