Homo sapiens Gene: MS4A1
Summary
InnateDB Gene IDBG-49101.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MS4A1
Gene Name membrane-spanning 4-domains, subfamily A, member 1
Synonyms B1; Bp35; CD20; CVID5; LEU-16; MS4A2; S7;
Species Homo sapiens
Ensembl Gene ENSG00000156738
Encoded Proteins
membrane-spanning 4-domains, subfamily A, member 1
membrane-spanning 4-domains, subfamily A, member 1
membrane-spanning 4-domains, subfamily A, member 1
membrane-spanning 4-domains, subfamily A, member 1
membrane-spanning 4-domains, subfamily A, member 1
membrane-spanning 4-domains, subfamily A, member 1
membrane-spanning 4-domains, subfamily A, member 1
membrane-spanning 4-domains, subfamily A, member 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the membrane-spanning 4A gene family. Members of this nascent protein family are characterized by common structural features and similar intron/exon splice boundaries and display unique expression patterns among hematopoietic cells and nonlymphoid tissues. This gene encodes a B-lymphocyte surface molecule which plays a role in the development and differentiation of B-cells into plasma cells. This family member is localized to 11q12, among a cluster of family members. Alternative splicing of this gene results in two transcript variants which encode the same protein. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:60455752-60470760
Strand Forward strand
Band q12.2
Transcripts
ENST00000345732 ENSP00000314620
ENST00000389939 ENSP00000374589
ENST00000524807 ENSP00000433179
ENST00000532491 ENSP00000432219
ENST00000527101
ENST00000532073 ENSP00000433519
ENST00000534668 ENSP00000433277
ENST00000528313 ENSP00000432270
ENST00000534503
ENST00000533306 ENSP00000437002
ENST00000532418
ENST00000530482
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 15 experimentally validated interaction(s) in this database.
Experimentally validated
Total 15 [view]
Protein-Protein 12 [view]
Protein-DNA 3 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005154 epidermal growth factor receptor binding
GO:0023026 MHC class II protein complex binding
Biological Process
GO:0006959 humoral immune response
GO:0042100 B cell proliferation
Cellular Component
GO:0005615 extracellular space
GO:0005887 integral component of plasma membrane
GO:0009897 external side of plasma membrane
GO:0016021 integral component of membrane
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Not yet available
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Pathways
NETPATH
REACTOME
KEGG
Hematopoietic cell lineage pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL B4DT24
UniProt Splice Variant
Entrez Gene 931
UniGene Hs.438040 Hs.712553
RefSeq NM_021950 NM_152866
HUGO HGNC:7315
OMIM 112210
CCDS CCDS31570
HPRD 00204
IMGT
EMBL AK300025 AP001034 AP003127
GenPept BAG61836
RNA Seq Atlas 931