Homo sapiens Gene: PPP1R12A | |||||||||||||||||||||||
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Summary | |||||||||||||||||||||||
InnateDB Gene | IDBG-49402.6 | ||||||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||
Gene Symbol | PPP1R12A | ||||||||||||||||||||||
Gene Name | protein phosphatase 1, regulatory subunit 12A | ||||||||||||||||||||||
Synonyms | M130; MBS; MYPT1 | ||||||||||||||||||||||
Species | Homo sapiens | ||||||||||||||||||||||
Ensembl Gene | ENSG00000058272 | ||||||||||||||||||||||
Encoded Proteins |
protein phosphatase 1, regulatory subunit 12A
protein phosphatase 1, regulatory subunit 12A
protein phosphatase 1, regulatory subunit 12A
protein phosphatase 1, regulatory subunit 12A
protein phosphatase 1, regulatory subunit 12A
protein phosphatase 1, regulatory subunit 12A
protein phosphatase 1, regulatory subunit 12A
protein phosphatase 1, regulatory subunit 12A
protein phosphatase 1, regulatory subunit 12A
protein phosphatase 1, regulatory subunit 12A
protein phosphatase 1, regulatory subunit 12A
protein phosphatase 1, regulatory subunit 12A
protein phosphatase 1, regulatory subunit 12A
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Protein Structure | |||||||||||||||||||||||
Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||||||
Entrez Gene | |||||||||||||||||||||||
Summary |
Myosin phosphatase target subunit 1, which is also called the myosin-binding subunit of myosin phosphatase, is one of the subunits of myosin phosphatase. Myosin phosphatase regulates the interaction of actin and myosin downstream of the guanosine triphosphatase Rho. The small guanosine triphosphatase Rho is implicated in myosin light chain (MLC) phosphorylation, which results in contraction of smooth muscle and interaction of actin and myosin in nonmuscle cells. The guanosine triphosphate (GTP)-bound, active form of RhoA (GTP.RhoA) specifically interacted with the myosin-binding subunit (MBS) of myosin phosphatase, which regulates the extent of phosphorylation of MLC. Rho-associated kinase (Rho-kinase), which is activated by GTP. RhoA, phosphorylated MBS and consequently inactivated myosin phosphatase. Overexpression of RhoA or activated RhoA in NIH 3T3 cells increased phosphorylation of MBS and MLC. Thus, Rho appears to inhibit myosin phosphatase through the action of Rho-kinase. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2009] |
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Gene Information | |||||||||||||||||||||||
Type | Protein coding | ||||||||||||||||||||||
Genomic Location | Chromosome 12:79773563-79935460 | ||||||||||||||||||||||
Strand | Reverse strand | ||||||||||||||||||||||
Band | q21.31 | ||||||||||||||||||||||
Transcripts | |||||||||||||||||||||||
Interactions | |||||||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 72 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
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Gene Ontology | |||||||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Orthologs | |||||||||||||||||||||||
Species
Mus musculus
Bos taurus
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Gene ID
Gene Order
Not yet available
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Pathways | |||||||||||||||||||||||
NETPATH |
EGFR1 pathway
TNFalpha pathway
TSLP pathway
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REACTOME |
Regulation of PLK1 Activity at G2/M Transition pathway
Cell Cycle pathway
G2/M Transition pathway
Cell Cycle, Mitotic pathway
Mitotic G2-G2/M phases pathway
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KEGG |
Regulation of actin cytoskeleton pathway
Focal adhesion pathway
Vascular smooth muscle contraction pathway
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INOH | |||||||||||||||||||||||
PID NCI |
Integrin-linked kinase signaling
RhoA signaling pathway
PLK1 signaling events
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Cross-References | |||||||||||||||||||||||
SwissProt | |||||||||||||||||||||||
TrEMBL | F8VW28 H0YHL8 | ||||||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||||||
Entrez Gene | 4659 | ||||||||||||||||||||||
UniGene | Hs.49582 | ||||||||||||||||||||||
RefSeq | NM_001143885 NM_001143886 NM_001244990 NM_001244992 NM_002480 XM_005268885 XM_005268888 XM_005268889 XM_005268891 XM_005268892 | ||||||||||||||||||||||
HUGO | HGNC:7618 | ||||||||||||||||||||||
OMIM | 602021 | ||||||||||||||||||||||
CCDS | CCDS44947 CCDS44948 CCDS58259 CCDS58260 | ||||||||||||||||||||||
HPRD | 03606 | ||||||||||||||||||||||
IMGT | |||||||||||||||||||||||
EMBL | AC018476 AC073569 AC074270 | ||||||||||||||||||||||
GenPept | |||||||||||||||||||||||
RNA Seq Atlas | 4659 | ||||||||||||||||||||||