Homo sapiens Gene: PPP1R12A
Summary
InnateDB Gene IDBG-49402.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PPP1R12A
Gene Name protein phosphatase 1, regulatory subunit 12A
Synonyms M130; MBS; MYPT1;
Species Homo sapiens
Ensembl Gene ENSG00000058272
Encoded Proteins
protein phosphatase 1, regulatory subunit 12A
protein phosphatase 1, regulatory subunit 12A
protein phosphatase 1, regulatory subunit 12A
protein phosphatase 1, regulatory subunit 12A
protein phosphatase 1, regulatory subunit 12A
protein phosphatase 1, regulatory subunit 12A
protein phosphatase 1, regulatory subunit 12A
protein phosphatase 1, regulatory subunit 12A
protein phosphatase 1, regulatory subunit 12A
protein phosphatase 1, regulatory subunit 12A
protein phosphatase 1, regulatory subunit 12A
protein phosphatase 1, regulatory subunit 12A
protein phosphatase 1, regulatory subunit 12A
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Myosin phosphatase target subunit 1, which is also called the myosin-binding subunit of myosin phosphatase, is one of the subunits of myosin phosphatase. Myosin phosphatase regulates the interaction of actin and myosin downstream of the guanosine triphosphatase Rho. The small guanosine triphosphatase Rho is implicated in myosin light chain (MLC) phosphorylation, which results in contraction of smooth muscle and interaction of actin and myosin in nonmuscle cells. The guanosine triphosphate (GTP)-bound, active form of RhoA (GTP.RhoA) specifically interacted with the myosin-binding subunit (MBS) of myosin phosphatase, which regulates the extent of phosphorylation of MLC. Rho-associated kinase (Rho-kinase), which is activated by GTP. RhoA, phosphorylated MBS and consequently inactivated myosin phosphatase. Overexpression of RhoA or activated RhoA in NIH 3T3 cells increased phosphorylation of MBS and MLC. Thus, Rho appears to inhibit myosin phosphatase through the action of Rho-kinase. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 12:79773563-79935460
Strand Reverse strand
Band q21.31
Transcripts
ENST00000261207 ENSP00000261207
ENST00000450142 ENSP00000389168
ENST00000437004 ENSP00000416769
ENST00000546762 ENSP00000450059
ENST00000550903 ENSP00000449647
ENST00000547253
ENST00000550351
ENST00000550299 ENSP00000449666
ENST00000546369 ENSP00000449514
ENST00000550107 ENSP00000446855
ENST00000548908
ENST00000552892
ENST00000550369
ENST00000551781
ENST00000553081 ENSP00000447144
ENST00000547330 ENSP00000446816
ENST00000550007
ENST00000547131 ENSP00000450061
ENST00000550001
ENST00000550510 ENSP00000447338
ENST00000551191
ENST00000548318 ENSP00000449843
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 72 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 72 [view]
Protein-Protein 69 [view]
Protein-DNA 3 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004857 enzyme inhibitor activity
GO:0004871 signal transducer activity
GO:0005515 protein binding
GO:0019208 phosphatase regulator activity
GO:0019901 protein kinase binding
GO:0071889 14-3-3 protein binding
Biological Process
GO:0000086 G2/M transition of mitotic cell cycle
GO:0000278 mitotic cell cycle
GO:0006470 protein dephosphorylation
GO:0007067 mitotic nuclear division
GO:0007165 signal transduction
GO:0030155 regulation of cell adhesion
GO:0035507 regulation of myosin-light-chain-phosphatase activity
GO:0043086 negative regulation of catalytic activity
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0046822 regulation of nucleocytoplasmic transport
GO:0051297 centrosome organization
Cellular Component
GO:0000776 kinetochore
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005813 centrosome
GO:0015629 actin cytoskeleton
GO:0043292 contractile fiber
GO:0072357 PTW/PP1 phosphatase complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
EGFR1 pathway
TNFalpha pathway
TSLP pathway
REACTOME
Regulation of PLK1 Activity at G2/M Transition pathway
Cell Cycle pathway
G2/M Transition pathway
Cell Cycle, Mitotic pathway
Mitotic G2-G2/M phases pathway
KEGG
Vascular smooth muscle contraction pathway
Focal adhesion pathway
Regulation of actin cytoskeleton pathway
INOH
PID BIOCARTA
PID NCI
Integrin-linked kinase signaling
RhoA signaling pathway
PLK1 signaling events
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.49582
RefSeq NM_001143885 NM_001143886 NM_001244990 NM_001244992 NM_002480 XM_005268885 XM_005268888 XM_005268889 XM_005268891 XM_005268892
HUGO
OMIM
CCDS CCDS44947 CCDS44948 CCDS58259 CCDS58260
HPRD 03606
IMGT
EMBL
GenPept
RNA Seq Atlas