Homo sapiens Gene: NUB1
Summary
InnateDB Gene IDBG-49516.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol NUB1
Gene Name negative regulator of ubiquitin-like proteins 1
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000013374
Encoded Proteins
negative regulator of ubiquitin-like proteins 1
negative regulator of ubiquitin-like proteins 1
negative regulator of ubiquitin-like proteins 1
negative regulator of ubiquitin-like proteins 1
negative regulator of ubiquitin-like proteins 1
negative regulator of ubiquitin-like proteins 1
negative regulator of ubiquitin-like proteins 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a protein that functions as a negative regulator of NEDD8, a ubiquitin-like protein that conjugates with cullin family members in order to regulate vital biological events. The protein encoded by this gene regulates the NEDD8 conjugation system post-transcriptionally by recruiting NEDD8 and its conjugates to the proteasome for degradation. This protein interacts with the product of the AIPL1 gene, which is associated with Leber congenital amaurosis, an inherited retinopathy, and mutations in that gene can abolish interaction with this protein, which may contribute to the pathogenesis. This protein is also known to accumulate in Lewy bodies in Parkinson's disease and dementia with Lewy bodies, and in glial cytoplasmic inclusions in multiple system atrophy, with this abnormal accumulation being specific to alpha-synucleinopathy lesions. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Aug 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:151341699-151378449
Strand Forward strand
Band q36.1
Transcripts
ENST00000413040 ENSP00000398644
ENST00000468404 ENSP00000420638
ENST00000470229 ENSP00000418234
ENST00000470316 ENSP00000420023
ENST00000483358 ENSP00000420086
ENST00000493588
ENST00000480907
ENST00000477666
ENST00000497987
ENST00000460712 ENSP00000420344
ENST00000480714 ENSP00000419679
ENST00000568733 ENSP00000454264
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 156 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 156 [view]
Protein-Protein 156 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0006511 ubiquitin-dependent protein catabolic process
GO:0016567 protein ubiquitination
GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0034341 response to interferon-gamma
GO:0034612 response to tumor necrosis factor
Cellular Component
GO:0005634 nucleus
GO:0005730 nucleolus
GO:0005737 cytoplasm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.647082 Hs.725338
RefSeq NM_001243351 NM_016118 XM_005250010 XM_005250011
HUGO
OMIM
CCDS CCDS47751 CCDS59089
HPRD 07450
IMGT
EMBL
GenPept
RNA Seq Atlas