Homo sapiens Gene: LGALS4
Summary
InnateDB Gene IDBG-49542.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol LGALS4
Gene Name lectin, galactoside-binding, soluble, 4
Synonyms GAL4; L36LBP;
Species Homo sapiens
Ensembl Gene ENSG00000171747
Encoded Proteins
lectin, galactoside-binding, soluble, 4
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
LGALS4 (Gal-4), expressed in the intestinal tract, recognizes and kills human blood group antigen-expressing Escherichia coli while failing to alter the viability of other E. coli strains or other Gram-negative or Gram-positive organisms.
LGALS4 is part of the galectin family of proteins that have emerged as autonomous bacteria-killing agents, pointing to a principal role of these proteins in innate immunity.
Entrez Gene
Summary The galectins are a family of beta-galactoside-binding proteins implicated in modulating cell-cell and cell-matrix interactions. The expression of this gene is restricted to small intestine, colon, and rectum, and it is underexpressed in colorectal cancer. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 19:38801671-38813364
Strand Reverse strand
Band q13.2
Transcripts
ENST00000307751 ENSP00000302100
ENST00000595291 ENSP00000471757
ENST00000595342
ENST00000595278
ENST00000596628
ENST00000597153
ENST00000600070 ENSP00000470387
ENST00000597803
ENST00000594209 ENSP00000472990
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
Experimentally validated
Total 6 [view]
Protein-Protein 6 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0030246 carbohydrate binding
Biological Process
GO:0007155 cell adhesion
GO:0045087 innate immune response (InnateDB)
Cellular Component
GO:0005829 cytosol
GO:0005886 plasma membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.5302
RefSeq NM_006149
HUGO
OMIM
CCDS CCDS12521
HPRD 03949
IMGT
EMBL
GenPept
RNA Seq Atlas