Homo sapiens Gene: LGALS4
Summary
InnateDB Gene IDBG-49542.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol LGALS4
Gene Name lectin, galactoside-binding, soluble, 4
Synonyms GAL4; L36LBP
Species Homo sapiens
Ensembl Gene ENSG00000171747
Encoded Proteins
lectin, galactoside-binding, soluble, 4
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
LGALS4 (Gal-4), expressed in the intestinal tract, recognizes and kills human blood group antigen-expressing Escherichia coli while failing to alter the viability of other E. coli strains or other Gram-negative or Gram-positive organisms.
LGALS4 is part of the galectin family of proteins that have emerged as autonomous bacteria-killing agents, pointing to a principal role of these proteins in innate immunity.
Entrez Gene
Summary The galectins are a family of beta-galactoside-binding proteins implicated in modulating cell-cell and cell-matrix interactions. The expression of this gene is restricted to small intestine, colon, and rectum, and it is underexpressed in colorectal cancer. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 19:38801671-38813364
Strand Reverse strand
Band q13.2
Transcripts
ENST00000307751 ENSP00000302100
ENST00000595291 ENSP00000471757
ENST00000595342
ENST00000595278
ENST00000596628
ENST00000597153
ENST00000600070 ENSP00000470387
ENST00000597803
ENST00000594209 ENSP00000472990
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
Experimentally validated
Total 6 [view]
Protein-Protein 6 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0030246 carbohydrate binding
Biological Process
GO:0007155 cell adhesion
GO:0045087 innate immune response (InnateDB)
Cellular Component
GO:0005829 cytosol
GO:0005886 plasma membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Not yet available
Cross-References
SwissProt
TrEMBL M0R349
UniProt Splice Variant
Entrez Gene 3960
UniGene Hs.5302
RefSeq NM_006149
HUGO HGNC:6565
OMIM 602518
CCDS CCDS12521
HPRD 03949
IMGT
EMBL AC022144 AC104534
GenPept
RNA Seq Atlas 3960