InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: SLC5A1

Summary

InnateDB Gene

IDBG-4964.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SLC5A1

Gene Name

solute carrier family 5 (sodium/glucose cotransporter), member 1

Synonyms

D22S675; NAGT; SGLT1

Species

Homo sapiens

Ensembl Gene

ENSG00000100170

Encoded Proteins

IDBP-4966

solute carrier family 5 (sodium/glucose cotransporter), member 1

IDBP-592206

solute carrier family 5 (sodium/glucose cotransporter), member 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a member of the sodium-dependent glucose transporter (SGLT) family. The encoded integral membrane protein is the primary mediator of dietary glucose and galactose uptake from the intestinal lumen. Mutations in this gene have been associated with glucose-galactose malabsorption. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 22:32043032-32113029

Strand

Forward strand

Band

q12.3

Transcripts

ENST00000266088	ENSP00000266088
ENST00000486394
ENST00000477969
ENST00000543737	ENSP00000444898

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005215	transporter activity
GO:0005355	glucose transmembrane transporter activity
GO:0005412	glucose:sodium symporter activity
GO:0005515	protein binding

Biological Process

GO:0005975	carbohydrate metabolic process
GO:0006810	transport
GO:0006814	sodium ion transport
GO:0008645	hexose transport
GO:0015758	glucose transport
GO:0044281	small molecule metabolic process
GO:0050892	intestinal absorption
GO:0055085	transmembrane transport

Cellular Component

GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0005903	brush border
GO:0005911	cell-cell junction
GO:0016020	membrane
GO:0016324	apical plasma membrane
GO:0031526	brush border membrane
GO:0070062	extracellular vesicular exosome