Homo sapiens Gene: SLC5A1
Summary
InnateDB Gene IDBG-4964.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SLC5A1
Gene Name solute carrier family 5 (sodium/glucose cotransporter), member 1
Synonyms D22S675; NAGT; SGLT1;
Species Homo sapiens
Ensembl Gene ENSG00000100170
Encoded Proteins
solute carrier family 5 (sodium/glucose cotransporter), member 1
solute carrier family 5 (sodium/glucose cotransporter), member 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the sodium-dependent glucose transporter (SGLT) family. The encoded integral membrane protein is the primary mediator of dietary glucose and galactose uptake from the intestinal lumen. Mutations in this gene have been associated with glucose-galactose malabsorption. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 22:32043032-32113029
Strand Forward strand
Band q12.3
Transcripts
ENST00000266088 ENSP00000266088
ENST00000486394
ENST00000477969
ENST00000543737 ENSP00000444898
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005215 transporter activity
GO:0005355 glucose transmembrane transporter activity
GO:0005412 glucose:sodium symporter activity
GO:0005515 protein binding
Biological Process
GO:0005975 carbohydrate metabolic process
GO:0006810 transport
GO:0006814 sodium ion transport
GO:0008645 hexose transport
GO:0015758 glucose transport
GO:0044281 small molecule metabolic process
GO:0050892 intestinal absorption
GO:0055085 transmembrane transport
Cellular Component
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0005903 brush border
GO:0005911 cell-cell junction
GO:0016020 membrane
GO:0016324 apical plasma membrane
GO:0031526 brush border membrane
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Transmembrane transport of small molecules pathway
Myoclonic epilepsy of Lafora pathway
Hexose transport pathway
Metabolism of carbohydrates pathway
Inositol transporters pathway
Na+-dependent glucose transporters pathway
Orphan transporters pathway
Metabolism pathway
SLC-mediated transmembrane transport pathway
Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds pathway
Disease pathway
Glycogen storage diseases pathway
KEGG
Carbohydrate digestion and absorption pathway
Bile secretion pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt P13866
TrEMBL
UniProt Splice Variant
Entrez Gene 6523
UniGene Hs.1964
RefSeq NM_001256314 NM_000343
HUGO HGNC:11036
OMIM 182380
CCDS CCDS58805 CCDS13902
HPRD 01668
IMGT
EMBL AK297665 AK312948 AK316184 AL022321 CH471095 CR456579 L29328 L29329 L29330 L29331 L29332 L29333 L29334 L29335 L29336 L29337 L29338 L29339 M24847 Z74021 Z80998 Z83839 Z83849
GenPept AAA60320 AAB59448 BAG35789 BAH12645 BAH14555 CAB06087 CAG30465 CAI18756 CAI18759 CAI19810 CAI23589 EAW60006
RNA Seq Atlas 6523