Homo sapiens Gene: GAST
Summary
InnateDB Gene IDBG-49678.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol GAST
Gene Name gastrin
Synonyms GAS;
Species Homo sapiens
Ensembl Gene ENSG00000184502
Encoded Proteins
gastrin
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Gastrin is a hormone whose main function is to stimulate secretion of hydrochloric acid by the gastric mucosa, which results in gastrin formation inhibition. This hormone also acts as a mitogenic factor for gastrointestinal epithelial cells. Gastrin has two biologically active peptide forms, G34 and G17. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:41712326-41715969
Strand Forward strand
Band q21.2
Transcripts
ENST00000329402 ENSP00000331358
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005179 hormone activity
GO:0005515 protein binding
Biological Process
GO:0007165 signal transduction
GO:0007186 G-protein coupled receptor signaling pathway
Cellular Component
GO:0005576 extracellular region
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Gastrin-CREB signalling pathway via PKC and MAPK pathway
G alpha (q) signalling events pathway
Signaling by GPCR pathway
Signal Transduction pathway
GPCR downstream signaling pathway
KEGG
Gastric acid secretion pathway
INOH
GPCR signaling pathway
PID BIOCARTA
PID NCI
Cross-References
SwissProt P01350
TrEMBL
UniProt Splice Variant
Entrez Gene 2520
UniGene Hs.2681
RefSeq NM_000805
HUGO HGNC:4164
OMIM 137250
CCDS CCDS11404
HPRD
IMGT
EMBL BC069724 BC069762 K01254 M15958 V00511 X00183
GenPept AAA52520 AAB59533 AAH69724 AAH69762 CAA23769 CAA25005 CAA25006 CAA25007
RNA Seq Atlas 2520