Version 5.4
Homo sapiens Gene: PRNP
Summary
InnateDB Gene IDBG-49833.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PRNP
Gene Name prion protein
Synonyms AltPrP; ASCR; CD230; CJD; GSS; KURU; p27-30; PRIP; PrP; PrP27-30; PrP33-35C; PrPc
Species Homo sapiens
Ensembl Gene ENSG00000171867
Encoded Proteins
IDBP-49835
prion protein
IDBP-364801
prion protein
IDBP-364807
prion protein
IDBP-364815
prion protein
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a membrane glycosylphosphatidylinositol-anchored glycoprotein that tends to aggregate into rod-like structures. The encoded protein contains a highly unstable region of five tandem octapeptide repeats. This gene is found on chromosome 20, approximately 20 kbp upstream of a gene which encodes a biochemically and structurally similar protein to the one encoded by this gene. Mutations in the repeat region as well as elsewhere in this gene have been associated with Creutzfeldt-Jakob disease, fatal familial insomnia, Gerstmann-Straussler disease, Huntington disease-like 1, and kuru. An overlapping open reading frame has been found for this gene that encodes a smaller, structurally unrelated protein, AltPrp. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 20:4686236-4701590
Strand Forward strand
Band p13
Transcripts
ENST00000379440 ENSP00000368752
ENST00000430350 ENSP00000399376
ENST00000424424 ENSP00000411599
ENST00000457586 ENSP00000415284
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 94 experimentally validated interaction(s) in this database.
They are also associated with 44 interaction(s) predicted by orthology.
Experimentally validated
Total 94 [view]
Protein-Protein 93 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 1 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 44 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005507 copper ion binding
GO:0005515 protein binding
GO:0008017 microtubule binding
GO:0015631 tubulin binding
GO:0042802 identical protein binding
GO:0043008 ATP-dependent protein binding
GO:0051087 chaperone binding
Biological Process
GO:0001933 negative regulation of protein phosphorylation
GO:0006878 cellular copper ion homeostasis
GO:0006979 response to oxidative stress
GO:0007050 cell cycle arrest
GO:0007411 axon guidance
GO:0007611 learning or memory
GO:0008152 metabolic process
GO:0032689 negative regulation of interferon-gamma production
GO:0032700 negative regulation of interleukin-17 production
GO:0032703 negative regulation of interleukin-2 production
GO:0032880 regulation of protein localization
GO:0043066 negative regulation of apoptotic process
GO:0043433 negative regulation of sequence-specific DNA binding transcription factor activity
GO:0046007 negative regulation of activated T cell proliferation
GO:0046686 response to cadmium ion
GO:0046688 response to copper ion
GO:0050860 negative regulation of T cell receptor signaling pathway
GO:0051260 protein homooligomerization
GO:0070885 negative regulation of calcineurin-NFAT signaling cascade
GO:1901379 regulation of potassium ion transmembrane transport
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005783 endoplasmic reticulum
GO:0005794 Golgi apparatus
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0019898 extrinsic component of membrane
GO:0031225 anchored component of membrane
GO:0045121 membrane raft
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000079037
View Gene Order
ENSBTAG00000027937
Not yet available
Pathways
NETPATH
REACTOME
REACT_18312
NCAM1 interactions pathway
REACT_18334
NCAM signaling for neurite out-growth pathway
REACT_111045
Developmental Biology pathway
REACT_18266
Axon guidance pathway
KEGG
hsa05020
Prion diseases pathway
INOH
PID NCI
glypican_1pathway
Glypican 1 network
Cross-References
SwissProt
TrEMBL A2A2V1 X6RKS3
UniProt Splice Variant
Entrez Gene 5621
UniGene Hs.472010
RefSeq NM_000311 NM_001080121 NM_001080122 NM_001080123 NM_001271561 NM_183079
HUGO HGNC:9449
OMIM 176640
CCDS CCDS13080
HPRD 01453
IMGT
EMBL AL133396
GenPept
RNA Seq Atlas 5621

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca