Homo sapiens Gene: SH3KBP1
Summary
InnateDB Gene IDBG-49936.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SH3KBP1
Gene Name SH3-domain kinase binding protein 1
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000147010
Encoded Proteins
SH3-domain kinase binding protein 1
SH3-domain kinase binding protein 1
SH3-domain kinase binding protein 1
SH3-domain kinase binding protein 1
SH3-domain kinase binding protein 1
SH3-domain kinase binding protein 1
SH3-domain kinase binding protein 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes an adapter protein that contains three N-terminal Src homology domains, a proline rich region and a C-terminal coiled-coil domain. The encoded protein facilitates protein-protein interactions and has been implicated in numerous cellular processes including apoptosis, cytoskeletal rearrangement, cell adhesion and in the regulation of clathrin-dependent endocytosis. Alternate splicing results in multiple transcript variants.[provided by RefSeq, May 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome X:19533975-19887601
Strand Reverse strand
Band p22.12
Transcripts
ENST00000379726 ENSP00000369049
ENST00000379716 ENSP00000369039
ENST00000379698 ENSP00000369020
ENST00000379697 ENSP00000369019
ENST00000397821 ENSP00000380921
ENST00000432234 ENSP00000388766
ENST00000431164 ENSP00000409292
ENST00000494961
ENST00000477102
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 306 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.
Experimentally validated
Total 306 [view]
Protein-Protein 304 [view]
Protein-DNA 0
Protein-RNA 1 [view]
DNA-DNA 1 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 8 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0016301 kinase activity
GO:0017124 SH3 domain binding
Biological Process
GO:0006897 endocytosis
GO:0006915 apoptotic process
GO:0007010 cytoskeleton organization
GO:0007173 epidermal growth factor receptor signaling pathway
GO:0007267 cell-cell signaling
GO:0008360 regulation of cell shape
GO:0016310 phosphorylation
GO:0016477 cell migration
GO:0042059 negative regulation of epidermal growth factor receptor signaling pathway
Cellular Component
GO:0005829 cytosol
GO:0005856 cytoskeleton
GO:0005886 plasma membrane
GO:0005911 cell-cell junction
GO:0005925 focal adhesion
GO:0030659 cytoplasmic vesicle membrane
GO:0043005 neuron projection
GO:0045202 synapse
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Not yet available
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Pathways
NETPATH
EGFR1 pathway
KitReceptor pathway
REACTOME
Signaling by EGFR in Cancer pathway
Signaling by EGFR pathway
Signal Transduction pathway
Adaptive Immune System pathway
Immune System pathway
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers pathway
EGFR downregulation pathway
Signaling by the B Cell Receptor (BCR) pathway
Disease pathway
KEGG
Endocytosis pathway
INOH
PID BIOCARTA
Cbl mediated ligand-induced downregulation of egf receptors pathway [Biocarta view]
Sprouty regulation of tyrosine kinase signals [Biocarta view]
PID NCI
Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
Internalization of ErbB1
Cross-References
SwissProt
TrEMBL Q5VSN0
UniProt Splice Variant
Entrez Gene 30011
UniGene Hs.726365
RefSeq NM_031892 NM_001184960 NM_001024666
HUGO HGNC:13867
OMIM 300374
CCDS CCDS14193 CCDS55383 CCDS35213
HPRD 02301
IMGT
EMBL AL732325 AL732327 AL732409 AL732423 AL772197
GenPept
RNA Seq Atlas 30011