Homo sapiens Gene: KAT2A
Summary
InnateDB Gene IDBG-50287.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol KAT2A
Gene Name K(lysine) acetyltransferase 2A
Synonyms GCN5; GCN5L2; hGCN5; PCAF-b;
Species Homo sapiens
Ensembl Gene ENSG00000108773
Encoded Proteins
K(lysine) acetyltransferase 2A
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary KAT2A, or GCN5, is a histone acetyltransferase (HAT) that functions primarily as a transcriptional activator. It also functions as a repressor of NF-kappa-B (see MIM 164011) by promoting ubiquitination of the NF-kappa-B subunit RELA (MIM 164014) in a HAT-independent manner (Mao et al., 2009 [PubMed 19339690]).[supplied by OMIM, Sep 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:42113108-42121358
Strand Reverse strand
Band q21.2
Transcripts
ENST00000225916 ENSP00000225916
ENST00000465682 ENSP00000468390
ENST00000592310
ENST00000586972
ENST00000588759 ENSP00000467324
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 150 experimentally validated interaction(s) in this database.
They are also associated with 11 interaction(s) predicted by orthology.
Experimentally validated
Total 150 [view]
Protein-Protein 149 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 1 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 11 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003682 chromatin binding
GO:0003713 transcription coactivator activity
GO:0004402 histone acetyltransferase activity
GO:0005515 protein binding
GO:0008080 N-acetyltransferase activity
GO:0010484 H3 histone acetyltransferase activity
GO:0042826 histone deacetylase binding
GO:0043997 histone acetyltransferase activity (H4-K12 specific)
Biological Process
GO:0001701 in utero embryonic development
GO:0001756 somitogenesis
GO:0001843 neural tube closure
GO:0006325 chromatin organization
GO:0006338 chromatin remodeling
GO:0006355 regulation of transcription, DNA-templated
GO:0006357 regulation of transcription from RNA polymerase II promoter
GO:0006366 transcription from RNA polymerase II promoter
GO:0007399 nervous system development
GO:0008152 metabolic process
GO:0008283 cell proliferation
GO:0016032 viral process
GO:0016573 histone acetylation
GO:0016578 histone deubiquitination
GO:0021537 telencephalon development
GO:0022037 metencephalon development
GO:0030901 midbrain development
GO:0031647 regulation of protein stability
GO:0035264 multicellular organism growth
GO:0043966 histone H3 acetylation
GO:0043983 histone H4-K12 acetylation
GO:0044154 histone H3-K14 acetylation
GO:0045722 positive regulation of gluconeogenesis
Cellular Component
GO:0000123 histone acetyltransferase complex
GO:0005615 extracellular space
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005671 Ada2/Gcn5/Ada3 transcription activator complex
GO:0030914 STAGA complex
GO:0033276 transcription factor TFTC complex
GO:0072686 mitotic spindle
Orthologs
Species
Mus musculus
Gene ID
Gene Order
Method
Confidence
Comments
Low
Tentative data, uncurated. RBBH derived.
Pathways
NETPATH
REACTOME
HATs acetylate histones pathway
Constitutive Signaling by NOTCH1 PEST Domain Mutants pathway
Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant pathway
RNA Polymerase I Transcription pathway
Pre-NOTCH Expression and Processing pathway
Notch-HLH transcription pathway pathway
NOTCH1 Intracellular Domain Regulates Transcription pathway
Signaling by NOTCH1 in Cancer pathway
FBXW7 Mutants and NOTCH1 in Cancer pathway
RNA Polymerase I Promoter Clearance pathway
Signal Transduction pathway
Pre-NOTCH Transcription and Translation pathway
Generic Transcription Pathway pathway
Signaling by NOTCH1 PEST Domain Mutants in Cancer pathway
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer pathway
Chromatin organization pathway
Signaling by NOTCH pathway
RNA Polymerase I Transcription Initiation pathway
Chromatin modifying enzymes pathway
Signaling by NOTCH1 pathway
Signaling by NOTCH1 HD Domain Mutants in Cancer pathway
RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription pathway
Gene Expression pathway
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants pathway
Disease pathway
KEGG
Notch signaling pathway pathway
INOH
PID BIOCARTA
PID NCI
Direct p53 effectors
Validated targets of C-MYC transcriptional activation
E2F transcription factor network
C-MYC pathway
Regulation of nuclear SMAD2/3 signaling
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.463045
RefSeq NM_021078 XM_006721817 XM_006721818
HUGO
OMIM
CCDS CCDS11417
HPRD 03807
IMGT
EMBL
GenPept
RNA Seq Atlas