Homo sapiens Gene: STAT5B
InnateDB Gene IDBG-50532.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol STAT5B
Gene Name signal transducer and activator of transcription 5B
Synonyms STAT5;
Species Homo sapiens
Ensembl Gene ENSG00000173757
Encoded Proteins
signal transducer and activator of transcription 5B
signal transducer and activator of transcription 5B
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
IL-2 and IL-7 induced heterodimerization of STAT5 isoforms in human peripheral blood T lymphoblast
Entrez Gene
Summary The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein mediates the signal transduction triggered by various cell ligands, such as IL2, IL4, CSF1, and different growth hormones. It has been shown to be involved in diverse biological processes, such as TCR signaling, apoptosis, adult mammary gland development, and sexual dimorphism of liver gene expression. This gene was found to fuse to retinoic acid receptor-alpha (RARA) gene in a small subset of acute promyelocytic leukemias (APLL). The dysregulation of the signaling pathways mediated by this protein may be the cause of the APLL. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:42199168-42276707
Strand Reverse strand
Band q21.2
ENST00000293328 ENSP00000293328
ENST00000415845 ENSP00000398379
Number of Interactions This gene and/or its encoded proteins are associated with 79 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.
Experimentally validated
Total 79 [view]
Protein-Protein 59 [view]
Protein-DNA 20 [view]
Protein-RNA 0
Predicted by orthology
Total 10 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0003690 double-stranded DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0004871 signal transducer activity
GO:0005509 calcium ion binding
GO:0005515 protein binding
GO:0019903 protein phosphatase binding
GO:0035259 glucocorticoid receptor binding
GO:0043565 sequence-specific DNA binding
GO:0046983 protein dimerization activity
Biological Process
GO:0000255 allantoin metabolic process
GO:0001553 luteinization
GO:0001666 response to hypoxia
GO:0001779 natural killer cell differentiation
GO:0001889 liver development
GO:0006101 citrate metabolic process
GO:0006103 2-oxoglutarate metabolic process
GO:0006105 succinate metabolic process
GO:0006107 oxaloacetate metabolic process
GO:0006355 regulation of transcription, DNA-templated
GO:0006357 regulation of transcription from RNA polymerase II promoter
GO:0006366 transcription from RNA polymerase II promoter
GO:0006549 isoleucine metabolic process
GO:0006573 valine metabolic process
GO:0006600 creatine metabolic process
GO:0006631 fatty acid metabolic process
GO:0006953 acute-phase response
GO:0007165 signal transduction
GO:0007259 JAK-STAT cascade
GO:0007548 sex differentiation
GO:0007565 female pregnancy
GO:0007595 lactation
GO:0008284 positive regulation of cell proliferation
GO:0019218 regulation of steroid metabolic process
GO:0019221 cytokine-mediated signaling pathway
GO:0019530 taurine metabolic process
GO:0019915 lipid storage
GO:0030155 regulation of cell adhesion
GO:0030856 regulation of epithelial cell differentiation
GO:0032355 response to estradiol
GO:0032496 response to lipopolysaccharide
GO:0032819 positive regulation of natural killer cell proliferation
GO:0032825 positive regulation of natural killer cell differentiation
GO:0032870 cellular response to hormone stimulus
GO:0033077 T cell differentiation in thymus
GO:0038161 prolactin signaling pathway
GO:0040014 regulation of multicellular organism growth
GO:0040018 positive regulation of multicellular organism growth
GO:0042104 positive regulation of activated T cell proliferation
GO:0042448 progesterone metabolic process
GO:0043029 T cell homeostasis
GO:0043066 negative regulation of apoptotic process
GO:0043434 response to peptide hormone
GO:0045086 positive regulation of interleukin-2 biosynthetic process
GO:0045087 innate immune response (InnateDB)
GO:0045471 response to ethanol
GO:0045579 positive regulation of B cell differentiation
GO:0045588 positive regulation of gamma-delta T cell differentiation
GO:0045621 positive regulation of lymphocyte differentiation
GO:0045647 negative regulation of erythrocyte differentiation
GO:0045931 positive regulation of mitotic cell cycle
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0045954 positive regulation of natural killer cell mediated cytotoxicity
GO:0046449 creatinine metabolic process
GO:0046543 development of secondary female sexual characteristics
GO:0046544 development of secondary male sexual characteristics
GO:0048541 Peyer's patch development
GO:0048661 positive regulation of smooth muscle cell proliferation
GO:0050729 positive regulation of inflammatory response
GO:0051272 positive regulation of cellular component movement
GO:0060397 JAK-STAT cascade involved in growth hormone signaling pathway
GO:0070669 response to interleukin-2
GO:0070670 response to interleukin-4
GO:0070672 response to interleukin-15
GO:0071363 cellular response to growth factor stimulus
GO:0071364 cellular response to epidermal growth factor stimulus
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005829 cytosol
Mus musculus
Bos taurus
Gene ID
Gene Order
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
EGFR1 pathway
KitReceptor pathway
TCR pathway
IL2 pathway
IL3 pathway
IL4 pathway
IL5 pathway
IL6 pathway
IL-7 pathway
IL9 pathway
Leptin pathway
TSLP pathway
Prolactin pathway
Oncostatin_M pathway
Signaling by FGFR in disease pathway
Signaling by FGFR mutants pathway
Interleukin-3, 5 and GM-CSF signaling pathway
Cytokine Signaling in Immune system pathway
Signaling by ERBB4 pathway
Signaling by FGFR1 mutants pathway
Signaling by SCF-KIT pathway
Signal Transduction pathway
Prolactin receptor signaling pathway
Immune System pathway
Downstream signal transduction pathway
Interleukin-2 signaling pathway
Growth hormone receptor signaling pathway
Signaling by Interleukins pathway
Interleukin-7 signaling pathway
Signaling by PDGF pathway
Nuclear signaling by ERBB4 pathway
Signaling by FGFR1 fusion mutants pathway
Disease pathway
Signaling by Leptin pathway
ErbB signaling pathway pathway
Chemokine signaling pathway pathway
Jak-STAT signaling pathway pathway
Pathways in cancer pathway
Chronic myeloid leukemia pathway
Acute myeloid leukemia pathway
PDGF signaling pathway pathway
IL-7 signaling pathway
IL-3 signaling pathway
JAK STAT pathway and regulation pathway
IL-2 signaling pathway
Growth hormone signaling pathway
EPO signaling pathway pathway
IL-5 signaling pathway
Inhibition of cellular proliferation by gleevec [Biocarta view]
Il 2 signaling pathway [Biocarta view]
Il 3 signaling pathway [Biocarta view]
Il-2 receptor beta chain in t cell activation [Biocarta view]
Epo signaling pathway [Biocarta view]
Growth hormone signaling pathway [Biocarta view]
Il22 soluble receptor signaling pathway [Biocarta view]
Tpo signaling pathway [Biocarta view]
Bioactive peptide induced signaling pathway [Biocarta view]
Il-7 signal transduction [Biocarta view]
ErbB4 signaling events
Signaling events mediated by PTP1B
FGF signaling pathway
Signaling events mediated by TCPTP
UniProt Splice Variant
Entrez Gene
UniGene Hs.595276 Hs.716852 Hs.743755
RefSeq NM_012448 XM_005257625
HPRD 05037
RNA Seq Atlas