Homo sapiens Gene: HDAC3
Summary
InnateDB Gene IDBG-50725.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol HDAC3
Gene Name histone deacetylase 3
Synonyms HD3; RPD3; RPD3-2;
Species Homo sapiens
Ensembl Gene ENSG00000171720
Encoded Proteins
histone deacetylase 3
histone deacetylase 3
histone deacetylase 3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to the histone deacetylase/acuc/apha family. It has histone deacetylase activity and represses transcription when tethered to a promoter. It may participate in the regulation of transcription through its binding with the zinc-finger transcription factor YY1. This protein can also down-regulate p53 function and thus modulate cell growth and apoptosis. This gene is regarded as a potential tumor suppressor gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:141620876-141636870
Strand Reverse strand
Band q31.3
Transcripts
ENST00000305264 ENSP00000302967
ENST00000469550
ENST00000469207
ENST00000459727
ENST00000491581
ENST00000486618
ENST00000467533
ENST00000492407
ENST00000475549
ENST00000523088 ENSP00000429099
ENST00000519474 ENSP00000430782
ENST00000476739
ENST00000495485
ENST00000490808
ENST00000471968
ENST00000492506
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 365 experimentally validated interaction(s) in this database.
They are also associated with 36 interaction(s) predicted by orthology.
Experimentally validated
Total 365 [view]
Protein-Protein 282 [view]
Protein-DNA 16 [view]
Protein-RNA 0
DNA-DNA 67 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 36 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0003714 transcription corepressor activity
GO:0004407 histone deacetylase activity
GO:0005515 protein binding
GO:0008134 transcription factor binding
GO:0016787 hydrolase activity
GO:0019899 enzyme binding
GO:0030332 cyclin binding
GO:0031490 chromatin DNA binding
GO:0032041 NAD-dependent histone deacetylase activity (H3-K14 specific)
GO:0033558 protein deacetylase activity
GO:0042826 histone deacetylase binding
GO:0046969 NAD-dependent histone deacetylase activity (H3-K9 specific)
GO:0046970 NAD-dependent histone deacetylase activity (H4-K16 specific)
GO:0097372 NAD-dependent histone deacetylase activity (H3-K18 specific)
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0006351 transcription, DNA-templated
GO:0006476 protein deacetylation
GO:0007219 Notch signaling pathway
GO:0007346 regulation of mitotic cell cycle
GO:0008152 metabolic process
GO:0016568 chromatin modification
GO:0016575 histone deacetylation
GO:0032922 circadian regulation of gene expression
GO:0040014 regulation of multicellular organism growth
GO:0043066 negative regulation of apoptotic process
GO:0044255 cellular lipid metabolic process
GO:0044281 small molecule metabolic process
GO:0045786 negative regulation of cell cycle
GO:0045892 negative regulation of transcription, DNA-templated
GO:0046329 negative regulation of JNK cascade
GO:0048011 neurotrophin TRK receptor signaling pathway
GO:0051225 spindle assembly
GO:0070932 histone H3 deacetylation
GO:0070933 histone H4 deacetylation
Cellular Component
GO:0000118 histone deacetylase complex
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005876 spindle microtubule
GO:0017053 transcriptional repressor complex
Orthologs
Species
Mus musculus
Gene ID
Gene Order
Method
Confidence
Comments
Low
Tentative data, uncurated. RBBH derived.
Pathways
NETPATH
REACTOME
Constitutive Signaling by NOTCH1 PEST Domain Mutants pathway
Organelle biogenesis and maintenance pathway
Developmental Biology pathway
Signalling by NGF pathway
Circadian Clock pathway
Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant pathway
Metabolism of lipids and lipoproteins pathway
NOTCH1 Intracellular Domain Regulates Transcription pathway
REV-ERBA represses gene expression pathway
Signaling by NOTCH1 in Cancer pathway
Mitochondrial biogenesis pathway
p75NTR negatively regulates cell cycle via SC1 pathway
p75 NTR receptor-mediated signalling pathway
PPARA activates gene expression pathway
FBXW7 Mutants and NOTCH1 in Cancer pathway
Signal Transduction pathway
BMAL1:CLOCK,NPAS2 activates circadian gene expression pathway
RORA activates circadian gene expression pathway
Signaling by NOTCH1 PEST Domain Mutants in Cancer pathway
HDACs deacetylate histones pathway
Transcriptional activation of mitochondrial biogenesis pathway
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer pathway
Chromatin organization pathway
Signaling by NOTCH pathway
Chromatin modifying enzymes pathway
Signaling by NOTCH1 pathway
Signaling by NOTCH1 HD Domain Mutants in Cancer pathway
Fatty acid, triacylglycerol, and ketone body metabolism pathway
Transcriptional regulation of white adipocyte differentiation pathway
Metabolism pathway
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) pathway
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants pathway
Disease pathway
KEGG
INOH
TGF-beta signaling pathway
PID BIOCARTA
Nuclear receptors coordinate the activities of chromatin remodeling complexes and coactivators to facilitate initiation of transcription in carcinoma cells [Biocarta view]
Acetylation and deacetylation of rela in nucleus [Biocarta view]
PID NCI
Regulation of retinoblastoma protein
Validated targets of C-MYC transcriptional repression
Signaling events mediated by HDAC Class I
Signaling events mediated by HDAC Class II
Retinoic acid receptors-mediated signaling
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.519632 Hs.605552
RefSeq NM_003883
HUGO
OMIM
CCDS CCDS4264
HPRD 08950
IMGT
EMBL
GenPept
RNA Seq Atlas