Homo sapiens Gene: FTH1
Summary
InnateDB Gene IDBG-50740.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol FTH1
Gene Name ferritin, heavy polypeptide 1
Synonyms FHC; FTH; FTHL6; HFE5; PIG15; PLIF;
Species Homo sapiens
Ensembl Gene ENSG00000167996
Encoded Proteins
ferritin, heavy polypeptide 1
ferritin, heavy polypeptide 1
ferritin, heavy polypeptide 1
ferritin, heavy polypeptide 1
ferritin, heavy polypeptide 1
ferritin, heavy polypeptide 1
ferritin, heavy polypeptide 1
ferritin, heavy polypeptide 1
ferritin, heavy polypeptide 1
ferritin, heavy polypeptide 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes the heavy subunit of ferritin, the major intracellular iron storage protein in prokaryotes and eukaryotes. It is composed of 24 subunits of the heavy and light ferritin chains. Variation in ferritin subunit composition may affect the rates of iron uptake and release in different tissues. A major function of ferritin is the storage of iron in a soluble and nontoxic state. Defects in ferritin proteins are associated with several neurodegenerative diseases. This gene has multiple pseudogenes. Several alternatively spliced transcript variants have been observed, but their biological validity has not been determined. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:61959718-61967660
Strand Reverse strand
Band q12.3
Transcripts
ENST00000273550 ENSP00000273550
ENST00000529191 ENSP00000431659
ENST00000529631 ENSP00000431575
ENST00000530019 ENSP00000433470
ENST00000532829 ENSP00000432223
ENST00000534180 ENSP00000434403
ENST00000526640 ENSP00000433321
ENST00000532601 ENSP00000435111
ENST00000534719
ENST00000533138
ENST00000529548 ENSP00000436947
ENST00000620041 ENSP00000484477
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 54 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 54 [view]
Protein-Protein 54 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004322 ferroxidase activity
GO:0005506 iron ion binding
GO:0005515 protein binding
GO:0008199 ferric iron binding
Biological Process
GO:0006826 iron ion transport
GO:0006879 cellular iron ion homeostasis
GO:0006880 intracellular sequestering of iron ion
GO:0006892 post-Golgi vesicle-mediated transport
GO:0006955 immune response
GO:0008285 negative regulation of cell proliferation
GO:0048147 negative regulation of fibroblast proliferation
GO:0055085 transmembrane transport
GO:0055114 oxidation-reduction process
GO:0061024 membrane organization
Cellular Component
GO:0005634 nucleus
GO:0005739 mitochondrion
GO:0005829 cytosol
GO:0008043 intracellular ferritin complex
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Transmembrane transport of small molecules pathway
trans-Golgi Network Vesicle Budding pathway
Iron uptake and transport pathway
Binding and Uptake of Ligands by Scavenger Receptors pathway
Scavenging by Class A Receptors pathway
Clathrin derived vesicle budding pathway
Golgi Associated Vesicle Biogenesis pathway
Membrane Trafficking pathway
KEGG
INOH
PID BIOCARTA
PID NCI
Validated targets of C-MYC transcriptional repression
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.645560
RefSeq NM_002032
HUGO
OMIM
CCDS CCDS41655
HPRD 00615
IMGT
EMBL
GenPept
RNA Seq Atlas