Homo sapiens Gene: INCENP
Summary
InnateDB Gene IDBG-50806.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol INCENP
Gene Name inner centromere protein antigens 135/155kDa
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000149503
Encoded Proteins
inner centromere protein antigens 135/155kDa
inner centromere protein antigens 135/155kDa
inner centromere protein antigens 135/155kDa
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary In mammalian cells, 2 broad groups of centromere-interacting proteins have been described: constitutively binding centromere proteins and 'passenger,' or transiently interacting, proteins (reviewed by Choo, 1997). The constitutive proteins include CENPA (centromere protein A; MIM 117139), CENPB (MIM 117140), CENPC1 (MIM 117141), and CENPD (MIM 117142). The term 'passenger proteins' encompasses a broad collection of proteins that localize to the centromere during specific stages of the cell cycle (Earnshaw and Mackay, 1994 [PubMed 8088460]). These include CENPE (MIM 117143); MCAK (MIM 604538); KID (MIM 603213); cytoplasmic dynein (e.g., MIM 600112); CliPs (e.g., MIM 179838); and CENPF/mitosin (MIM 600236). The inner centromere proteins (INCENPs) (Earnshaw and Cooke, 1991 [PubMed 1860899]), the initial members of the passenger protein group, display a broad localization along chromosomes in the early stages of mitosis but gradually become concentrated at centromeres as the cell cycle progresses into mid-metaphase. During telophase, the proteins are located within the midbody in the intercellular bridge, where they are discarded after cytokinesis (Cutts et al., 1999 [PubMed 10369859]).[supplied by OMIM, Mar 2008]
In mammalian cells, 2 broad groups of centromere-interacting proteins have been described: constitutively binding centromere proteins and \'passenger,\' or transiently interacting, proteins (reviewed by Choo, 1997). The constitutive proteins include CENPA (centromere protein A; MIM 117139), CENPB (MIM 117140), CENPC1 (MIM 117141), and CENPD (MIM 117142). The term \'passenger proteins\' encompasses a broad collection of proteins that localize to the centromere during specific stages of the cell cycle (Earnshaw and Mackay, 1994 [PubMed 8088460]). These include CENPE (MIM 117143); MCAK (MIM 604538); KID (MIM 603213); cytoplasmic dynein (e.g., MIM 600112); CliPs (e.g., MIM 179838); and CENPF/mitosin (MIM 600236). The inner centromere proteins (INCENPs) (Earnshaw and Cooke, 1991 [PubMed 1860899]), the initial members of the passenger protein group, display a broad localization along chromosomes in the early stages of mitosis but gradually become concentrated at centromeres as the cell cycle progresses into mid-metaphase. During telophase, the proteins are located within the midbody in the intercellular bridge, where they are discarded after cytokinesis (Cutts et al., 1999 [PubMed 10369859]).[supplied by OMIM, Mar 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:62123973-62153163
Strand Forward strand
Band q12.3
Transcripts
ENST00000278849 ENSP00000278849
ENST00000394818 ENSP00000378295
ENST00000533896 ENSP00000433100
ENST00000528037
ENST00000528375
ENST00000531099
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 38 experimentally validated interaction(s) in this database.
Experimentally validated
Total 38 [view]
Protein-Protein 35 [view]
Protein-DNA 3 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0000278 mitotic cell cycle
GO:0000910 cytokinesis
GO:0007059 chromosome segregation
GO:0007067 mitotic nuclear division
Cellular Component
GO:0000775 chromosome, centromeric region
GO:0000776 kinetochore
GO:0000777 condensed chromosome kinetochore
GO:0000795 synaptonemal complex
GO:0000800 lateral element
GO:0000801 central element
GO:0005721 centromeric heterochromatin
GO:0005819 spindle
GO:0005829 cytosol
GO:0005874 microtubule
GO:0010369 chromocenter
GO:0030496 midbody
GO:0043234 protein complex
Orthologs
Species
Mus musculus
Gene ID
Gene Order
Method
Confidence
Comments
Low
Tentative data, uncurated. RBBH derived.
Pathways
NETPATH
REACTOME
Separation of Sister Chromatids pathway
Mitotic Prometaphase pathway
Cell Cycle pathway
M Phase pathway
Mitotic Anaphase pathway
Cell Cycle, Mitotic pathway
Resolution of Sister Chromatid Cohesion pathway
Mitotic Metaphase and Anaphase pathway
KEGG
INOH
PID BIOCARTA
PID NCI
Aurora C signaling
Regulation of nuclear beta catenin signaling and target gene transcription
Aurora B signaling
PLK1 signaling events
Cross-References
SwissProt Q9NQS7
TrEMBL E9PM67
UniProt Splice Variant
Entrez Gene 3619
UniGene Hs.142179
RefSeq NM_001040694 XM_006718533 NM_020238
HUGO HGNC:6058
OMIM 604411
CCDS CCDS44624 CCDS31582
HPRD 05103
IMGT
EMBL AF282265 AP002793 AY714053 BC098576 CH471076
GenPept AAF87584 AAH98576 AAU04398 EAW74004
RNA Seq Atlas 3619