Homo sapiens Gene: UBE2N
InnateDB Gene IDBG-51220.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol UBE2N
Gene Name ubiquitin-conjugating enzyme E2N
Synonyms HEL-S-71; UBC13; UbcH-ben; UbcH13; UBCHBEN; UBC13
Species Homo sapiens
Ensembl Gene ENSG00000177889
Encoded Proteins
ubiquitin-conjugating enzyme E2N
ubiquitin-conjugating enzyme E2N
ubiquitin-conjugating enzyme E2N
ubiquitin-conjugating enzyme E2N
ubiquitin-conjugating enzyme E2N
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
UBE2N abalation resulted in defective B cell development and in impaired B cell and macrophage activation.
TRIM5 requires UBE2W, UBE2N and UBE2V2 enzymatic activities to inhibit retroviral DNA synthesis
Entrez Gene
Summary The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. Studies in mouse suggest that this protein plays a role in DNA postreplication repair. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 12:93405673-93442262
Strand Reverse strand
Band q22
ENST00000318066 ENSP00000316176
ENST00000550657 ENSP00000449352
ENST00000549833 ENSP00000450260
ENST00000549490 ENSP00000447009
ENST00000552442 ENSP00000448352
Number of Interactions This gene and/or its encoded proteins are associated with 231 experimentally validated interaction(s) in this database.
They are also associated with 17 interaction(s) predicted by orthology.
Experimentally validated
Total 231 [view]
Protein-Protein 224 [view]
Protein-DNA 3 [view]
Protein-RNA 0
DNA-DNA 4 [view]
Predicted by orthology
Total 17 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004842 ubiquitin-protein transferase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016881 acid-amino acid ligase activity
GO:0043130 ubiquitin binding
GO:0044822 poly(A) RNA binding
Biological Process
GO:0000724 double-strand break repair via homologous recombination
GO:0000729 DNA double-strand break processing
GO:0002224 toll-like receptor signaling pathway
GO:0002755 MyD88-dependent toll-like receptor signaling pathway
GO:0006282 regulation of DNA repair
GO:0006301 postreplication repair
GO:0006464 cellular protein modification process
GO:0006508 proteolysis
GO:0006511 ubiquitin-dependent protein catabolic process
GO:0008152 metabolic process
GO:0016567 protein ubiquitination
GO:0016574 histone ubiquitination
GO:0019221 cytokine-mediated signaling pathway
GO:0031058 positive regulation of histone modification
GO:0033182 regulation of histone ubiquitination
GO:0034134 toll-like receptor 2 signaling pathway
GO:0034142 toll-like receptor 4 signaling pathway
GO:0034146 toll-like receptor 5 signaling pathway
GO:0034162 toll-like receptor 9 signaling pathway
GO:0034166 toll-like receptor 10 signaling pathway
GO:0035872 nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway
GO:0038095 Fc-epsilon receptor signaling pathway
GO:0038123 toll-like receptor TLR1:TLR2 signaling pathway
GO:0038124 toll-like receptor TLR6:TLR2 signaling pathway
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0045087 innate immune response (InnateDB)
GO:0045739 positive regulation of DNA repair
GO:0050852 T cell receptor signaling pathway
GO:0051092 positive regulation of NF-kappaB transcription factor activity
GO:0051443 positive regulation of ubiquitin-protein transferase activity
GO:0070423 nucleotide-binding oligomerization domain containing signaling pathway
GO:0070534 protein K63-linked ubiquitination
Cellular Component
GO:0000151 ubiquitin ligase complex
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0031372 UBC13-MMS2 complex
GO:0035370 UBC13-UEV1A complex
GO:0043234 protein complex
GO:0070062 extracellular vesicular exosome
Mus musculus
Bos taurus
Gene ID
Gene Order
Not yet available
IL1 pathway
Antigen processing: Ubiquitination & Proteasome degradation pathway
IKK complex recruitment mediated by RIP1 pathway
MyD88-independent cascade pathway
Toll Like Receptor 3 (TLR3) Cascade pathway
IRAK1 recruits IKK complex pathway
MyD88:Mal cascade initiated on plasma membrane pathway
Toll Like Receptor TLR1:TLR2 Cascade pathway
Toll Like Receptor TLR6:TLR2 Cascade pathway
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling pathway
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation pathway
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation pathway
MyD88 dependent cascade initiated on endosome pathway
Toll Like Receptor 9 (TLR9) Cascade pathway
MyD88 cascade initiated on plasma membrane pathway
Toll Like Receptor 10 (TLR10) Cascade pathway
Toll Like Receptor 4 (TLR4) Cascade pathway
Toll Like Receptor 5 (TLR5) Cascade pathway
NOD1/2 Signaling Pathway pathway
Downstream TCR signaling pathway
ISG15 antiviral mechanism pathway
Interleukin-1 signaling pathway
FCERI mediated NF-kB activation pathway
Toll Like Receptor 7/8 (TLR7/8) Cascade pathway
TCR signaling pathway
Antiviral mechanism by IFN-stimulated genes pathway
Cytokine Signaling in Immune system pathway
Innate Immune System pathway
Toll Like Receptor 2 (TLR2) Cascade pathway
Toll-Like Receptors Cascades pathway
Fc epsilon receptor (FCERI) signaling pathway
Interferon Signaling pathway
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways pathway
Adaptive Immune System pathway
Immune System pathway
Signaling by Interleukins pathway
Activated TLR4 signalling pathway
Class I MHC mediated antigen processing & presentation pathway
TRIF-mediated TLR3/TLR4 signaling pathway
Ubiquitin mediated proteolysis pathway
CD4 T cell receptor signaling pathway
IL-1 signaling pathway pathway
Toll-like receptor signaling pathway pathway
B cell receptor signaling pathway
IL1-mediated signaling events
ATM pathway
UniProt Splice Variant
Entrez Gene 7334
UniGene Hs.524630 Hs.610461 Hs.619366
RefSeq NM_001012989 NM_003348
OMIM 603679
HPRD 04725
EMBL AC025260
RNA Seq Atlas 389898 7334