Homo sapiens Gene: PLXNC1
Summary
InnateDB Gene IDBG-51378.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PLXNC1
Gene Name plexin C1
Synonyms CD232; PLXN-C1; VESPR;
Species Homo sapiens
Ensembl Gene ENSG00000136040
Encoded Proteins
plexin C1
plexin C1
plexin C1
plexin C1
plexin C1
plexin C1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the plexin family. Plexins are transmembrane receptors for semaphorins, a large family of proteins that regulate axon guidance, cell motility and migration, and the immune response. The encoded protein and its ligand regulate melanocyte adhesion, and viral semaphorins may modulate the immune response by binding to this receptor. The encoded protein may be a tumor suppressor protein for melanoma. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Jan 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 12:94148723-94307675
Strand Forward strand
Band q22
Transcripts
ENST00000258526 ENSP00000258526
ENST00000546733
ENST00000551850 ENSP00000447843
ENST00000546659
ENST00000549810
ENST00000549217 ENSP00000446781
ENST00000550080 ENSP00000447625
ENST00000547057 ENSP00000446720
ENST00000551495
ENST00000545312 ENSP00000439225
ENST00000549187
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004872 receptor activity
GO:0005102 receptor binding
GO:0005515 protein binding
Biological Process
GO:0007155 cell adhesion
GO:0007165 signal transduction
GO:0007275 multicellular organismal development
GO:0007411 axon guidance
Cellular Component
GO:0005622 intracellular
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Developmental Biology pathway
Semaphorin interactions pathway
Other semaphorin interactions pathway
Axon guidance pathway
KEGG
Axon guidance pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL F8VUW4
UniProt Splice Variant
Entrez Gene 10154
UniGene Hs.584845
RefSeq NM_005761
HUGO HGNC:9106
OMIM 604259
CCDS CCDS9049
HPRD 05036
IMGT
EMBL AC073655 AC123567
GenPept
RNA Seq Atlas 10154