Homo sapiens Gene: COX17
Summary
InnateDB Gene IDBG-51411.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol COX17
Gene Name cytochrome c oxidase assembly homolog 17 (yeast)
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000138495
Encoded Proteins
COX17 cytochrome c oxidase assembly homolog (S. cerevisiae)
COX17 cytochrome c oxidase assembly homolog (S. cerevisiae)
COX17 cytochrome c oxidase assembly homolog (S. cerevisiae)
COX17 cytochrome c oxidase assembly homolog (S. cerevisiae)
COX17 cytochrome c oxidase assembly homolog (S. cerevisiae)
COX17 cytochrome c oxidase assembly homolog (S. cerevisiae)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Cytochrome c oxidase (COX), the terminal component of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. This component is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may function in the regulation and assembly of the complex. This nuclear gene encodes a protein which is not a structural subunit, but may be involved in the recruitment of copper to mitochondria for incorporation into the COX apoenzyme. This protein shares 92% amino acid sequence identity with mouse and rat Cox17 proteins. This gene is no longer considered to be a candidate gene for COX deficiency. A pseudogene COX17P has been found on chromosome 13. [provided by RefSeq, Jul 2008]
Cytochrome c oxidase (COX), the terminal component of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. This component is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may function in the regulation and assembly of the complex. This nuclear gene encodes a protein which is not a structural subunit, but may be involved in the recruitment of copper to mitochondria for incorporation into the COX apoenzyme. This protein shares 92%% amino acid sequence identity with mouse and rat Cox17 proteins. This gene is no longer considered to be a candidate gene for COX deficiency. A pseudogene COX17P has been found on chromosome 13. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:119654513-119677454
Strand Reverse strand
Band q13.33
Transcripts
ENST00000261070 ENSP00000261070
ENST00000490145 ENSP00000420406
ENST00000468918 ENSP00000417805
ENST00000486606 ENSP00000417120
ENST00000484810 ENSP00000417651
ENST00000497997
ENST00000497116 ENSP00000417923
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 15 experimentally validated interaction(s) in this database.
Experimentally validated
Total 15 [view]
Protein-Protein 15 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005507 copper ion binding
GO:0016531 copper chaperone activity
Biological Process
GO:0006091 generation of precursor metabolites and energy
GO:0006825 copper ion transport
GO:0007420 brain development
GO:0007507 heart development
Cellular Component
GO:0005737 cytoplasm
GO:0005758 mitochondrial intermembrane space
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Metabolism of proteins pathway
Mitochondrial protein import pathway
KEGG
Oxidative phosphorylation pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_005694
HUGO
OMIM
CCDS CCDS2993
HPRD 05314
IMGT
EMBL
GenPept
RNA Seq Atlas