|Homo sapiens Gene: AIRE|
|Last Modified||2014-10-13 [Report errors or provide feedback]|
|Gene Name||autoimmune regulator|
|Synonyms||AIRE1; APECED; APS1; APSI; PGA1;|
|Useful resources||Stemformatics EHFPI ImmGen|
AIRE transcriptionally upregulates TLR1/3/8 via direct interaction with the TLR promoters. In addition, AIRE also mediates the induction of IL1A, TNF, NOS2 and IFN-alpha expression upon TLR1 and TLR3 stimulation. (Demonstrated in murine model)
AIRE participates in Dectin-1 signalling, an anticandidal innate immune signalling pathway that specifically recognizes fungal beta-glucan. AIRE formes a transient complex with the known Dectin-1 pathway components phosphorylated SYK and CARD9 after receptor ligation and localizes with CLEC7A (Dectin-1) at the cell membrane.
|InnateDB Annotation from Orthologs|
[Mus musculus] Aire transcriptionally upregulates Tlr1/3/8 via direct interaction with the TLR promoters. In addition, Aire also mediates the induction of Il1a, Tnf, Nos2 and IFN-alpha expression upon Tlr1 and Tlr3 stimulation.
[Mus musculus] Aire participates in Dectin-1 signalling, an anticandidal innate immune signalling pathway that specifically recognizes fungal beta-glucan. Aire formes a transient complex with the known Dectin-1 pathway components phosphorylated Sykb and Card9 after receptor ligation and localizes with Clec7a (Dectin-1) at the cell membrane (Demonstrated in human)
This gene encodes a transcriptional regulator that forms nuclear bodies and interacts with the transcriptional coactivator CREB binding protein. The encoded protein plays an important role in immunity by regulating the expression of autoantigens and negative selection of autoreactive T-cells in the thymus. Mutations in this gene cause the rare autosomal-recessive systemic autoimmune disease termed autoimmune polyendocrinopathy with candidiasis and ectodermal dystrophy (APECED). [provided by RefSeq, Jun 2012]
|Genomic Location||Chromosome 21:44285838-44298648|
|Number of Interactions||
This gene and/or its encoded proteins are associated with 80 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Ubiquitin mediated proteolysis pathway
Primary immunodeficiency pathway
|UniProt Splice Variant|
|RNA Seq Atlas|