Homo sapiens Gene: NR2C1
Summary
InnateDB Gene IDBG-51526.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol NR2C1
Gene Name nuclear receptor subfamily 2, group C, member 1
Synonyms TR2;
Species Homo sapiens
Ensembl Gene ENSG00000120798
Encoded Proteins
nuclear receptor subfamily 2, group C, member 1
nuclear receptor subfamily 2, group C, member 1
nuclear receptor subfamily 2, group C, member 1
nuclear receptor subfamily 2, group C, member 1
nuclear receptor subfamily 2, group C, member 1
nuclear receptor subfamily 2, group C, member 1
nuclear receptor subfamily 2, group C, member 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a nuclear hormone receptor characterized by a highly conserved DNA binding domain (DBD), a variable hinge region, and a carboxy-terminal ligand binding domain (LBD) that is typical for all members of the steroid/thyroid hormone receptor superfamily. This protein also belongs to a large family of ligand-inducible transcription factors that regulate gene expression by binding to specific DNA sequences within promoters of target genes. Multiple alternatively spliced transcript variants have been described, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 12:95020229-95073703
Strand Reverse strand
Band q22
Transcripts
ENST00000333003 ENSP00000333275
ENST00000330677 ENSP00000328843
ENST00000393101 ENSP00000376813
ENST00000551647 ENSP00000450225
ENST00000552861
ENST00000549617
ENST00000546416
ENST00000547594
ENST00000552484
ENST00000545833
ENST00000552791 ENSP00000446817
ENST00000548252
ENST00000546367
ENST00000548966
ENST00000552417
ENST00000551386
ENST00000549482
ENST00000547469 ENSP00000446906
ENST00000622476 ENSP00000478728
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 35 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
Experimentally validated
Total 35 [view]
Protein-Protein 35 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 6 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0003707 steroid hormone receptor activity
GO:0004872 receptor activity
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0042803 protein homodimerization activity
GO:0042826 histone deacetylase binding
GO:0043565 sequence-specific DNA binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0006355 regulation of transcription, DNA-templated
GO:0006367 transcription initiation from RNA polymerase II promoter
GO:0010467 gene expression
GO:0043401 steroid hormone mediated signaling pathway
GO:0045892 negative regulation of transcription, DNA-templated
GO:0048386 positive regulation of retinoic acid receptor signaling pathway
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0016605 PML body
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
AndrogenReceptor pathway
REACTOME
Nuclear Receptor transcription pathway pathway
Generic Transcription Pathway pathway
Gene Expression pathway
KEGG
INOH
PID BIOCARTA
PID NCI
Signaling events mediated by HDAC Class I
Regulation of Androgen receptor activity
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_001032287 NM_001127362 NM_003297 XM_005269133 XM_006719586
HUGO
OMIM
CCDS CCDS41821 CCDS44953 CCDS9051
HPRD
IMGT
EMBL
GenPept
RNA Seq Atlas