Homo sapiens Gene: VPS25
Summary
InnateDB Gene IDBG-51652.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol VPS25
Gene Name vacuolar protein sorting 25 homolog (S. cerevisiae)
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000131475
Encoded Proteins
vacuolar protein sorting 25 homolog (S. cerevisiae)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary VPS25, VPS36 (MIM 610903), and SNF8 (MIM 610904) form ESCRT-II (endosomal sorting complex required for transport II), a complex involved in endocytosis of ubiquitinated membrane proteins. VPS25, VPS36, and SNF8 are also associated in a multiprotein complex with RNA polymerase II elongation factor (ELL; MIM 600284) (Slagsvold et al., 2005 [PubMed 15755741]; Kamura et al., 2001 [PubMed 11278625]).[supplied by OMIM, Mar 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:42773436-42779599
Strand Forward strand
Band q21.2
Transcripts
ENST00000253794 ENSP00000253794
ENST00000591584
ENST00000589577 ENSP00000467225
ENST00000589520 ENSP00000465798
ENST00000589219
ENST00000590339 ENSP00000466909
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 32 experimentally validated interaction(s) in this database.
Experimentally validated
Total 32 [view]
Protein-Protein 32 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0042803 protein homodimerization activity
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0015031 protein transport
GO:0016197 endosomal transport
GO:0061024 membrane organization
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005730 nucleolus
GO:0005739 mitochondrion
GO:0005829 cytosol
GO:0010008 endosome membrane
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Not yet available
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Pathways
NETPATH
REACTOME
Endosomal Sorting Complex Required For Transport (ESCRT) pathway
Membrane Trafficking pathway
KEGG
Endocytosis pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL K7EP45
UniProt Splice Variant
Entrez Gene 84313
UniGene
RefSeq NM_032353
HUGO HGNC:28122
OMIM 610907
CCDS CCDS11438
HPRD 14396
IMGT
EMBL AC100793
GenPept
RNA Seq Atlas 84313