InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: ADRB2

Summary

InnateDB Gene

IDBG-52685.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ADRB2

Gene Name

adrenoceptor beta 2, surface

Synonyms

ADRB2R; ADRBR; B2AR; BAR; BETA2AR

Species

Homo sapiens

Ensembl Gene

ENSG00000169252

Encoded Proteins

IDBP-52687

adrenergic, beta-2-, receptor, surface

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 21683614

Activation of ADRB2 on NOD2/TLR2-stimulated dendritic cells biases the cell priming ability towards an Th17 immune response. (Demonstrated in murine model)

InnateDB Annotation from Orthologs

Summary

PMID 21683614

[Mus musculus] Activation of Adrb2 on Nod2/Tlr2-stimulated dendritic cells biases the cell priming ability towards an Th17 immune response.

Entrez Gene

Summary

This gene encodes beta-2-adrenergic receptor which is a member of the G protein-coupled receptor superfamily. This receptor is directly associated with one of its ultimate effectors, the class C L-type calcium channel Ca(V)1.2. This receptor-channel complex also contains a G protein, an adenylyl cyclase, cAMP-dependent kinase, and the counterbalancing phosphatase, PP2A. The assembly of the signaling complex provides a mechanism that ensures specific and rapid signaling by this G protein-coupled receptor. This gene is intronless. Different polymorphic forms, point mutations, and/or downregulation of this gene are associated with nocturnal asthma, obesity and type 2 diabetes. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 5:148825245-148828687

Strand

Forward strand

Band

q32

Transcripts

ENST00000305988

ENSP00000305372

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 336 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	336 [view]
Protein-Protein	335 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004930	G-protein coupled receptor activity
GO:0004941	beta2-adrenergic receptor activity
GO:0005515	protein binding
GO:0008179	adenylate cyclase binding
GO:0015459	potassium channel regulator activity
GO:0019899	enzyme binding
GO:0042803	protein homodimerization activity
GO:0051380	norepinephrine binding

Biological Process

GO:0001993	regulation of systemic arterial blood pressure by norepinephrine-epinephrine
GO:0002024	diet induced thermogenesis
GO:0002025	vasodilation by norepinephrine-epinephrine involved in regulation of systemic arterial blood pressure
GO:0002028	regulation of sodium ion transport
GO:0002032	desensitization of G-protein coupled receptor protein signaling pathway by arrestin
GO:0006898	receptor-mediated endocytosis
GO:0007166	cell surface receptor signaling pathway
GO:0007171	activation of transmembrane receptor protein tyrosine kinase activity
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007188	adenylate cyclase-modulating G-protein coupled receptor signaling pathway
GO:0007189	adenylate cyclase-activating G-protein coupled receptor signaling pathway
GO:0007190	activation of adenylate cyclase activity
GO:0008333	endosome to lysosome transport
GO:0009409	response to cold
GO:0030501	positive regulation of bone mineralization
GO:0031398	positive regulation of protein ubiquitination
GO:0031649	heat generation
GO:0040015	negative regulation of multicellular organism growth
GO:0042312	regulation of vasodilation
GO:0043410	positive regulation of MAPK cascade
GO:0045087	innate immune response (InnateDB)
GO:0045453	bone resorption
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0045986	negative regulation of smooth muscle contraction
GO:0050873	brown fat cell differentiation
GO:0071875	adrenergic receptor signaling pathway

Cellular Component

GO:0005634	nucleus
GO:0005764	lysosome
GO:0005768	endosome
GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0016324	apical plasma membrane
GO:0043235	receptor complex

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000045730

View Gene Order

ENSBTAG00000002144

Not yet available

Pathways

NETPATH

REACTOME

REACT_19327

G alpha (s) signalling events pathway

REACT_16927

Adrenoceptors pathway

REACT_16983

Amine ligand-binding receptors pathway

REACT_14828

Class A/1 (Rhodopsin-like receptors) pathway

REACT_14797

Signaling by GPCR pathway

REACT_111102

Signal Transduction pathway

REACT_19184

GPCR downstream signaling pathway

REACT_21340

GPCR ligand binding pathway

KEGG

hsa04080

Neuroactive ligand-receptor interaction pathway

hsa04020

Calcium signaling pathway pathway

hsa04144

Endocytosis pathway

hsa04970

Salivary secretion pathway

INOH

PID NCI

arf6_traffickingpathway

Arf6 trafficking events

arf6_pathway

Arf6 signaling events

Cross-References

SwissProt

P07550

TrEMBL

Q9BYZ0 X5DQM5

UniProt Splice Variant

Entrez Gene

154

UniGene

Hs.2551 Hs.721212

RefSeq

NM_000024

HUGO

HGNC:286

OMIM

109690

CCDS

CCDS4292

HPRD

IMGT

EMBL

AF022953 AF022954 AF022955 AF022956 AF169225 AF202305 AF203386 AK223025 AK313151 AY011291 AY136741 BC012481 BC063486 BC073856 CH471062 DQ094845 EU332834 J02960 KJ534762 M15169 X04827 Y00106

GenPept

AAA88015 AAA88017 AAB82148 AAB82149 AAB82150 AAB82151 AAD48036 AAF17569 AAF20199 AAG35451 AAH12481 AAH63486 AAH73856 AAN01267 AAY88739 ABY87523 AHW56402 BAD96745 BAG35969 CAA28511 CAA68289 EAW61798

RNA Seq Atlas

154