Homo sapiens Gene: ADRB2
Summary
InnateDB Gene IDBG-52685.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ADRB2
Gene Name adrenoceptor beta 2, surface
Synonyms ADRB2R; ADRBR; B2AR; BAR; BETA2AR;
Species Homo sapiens
Ensembl Gene ENSG00000169252
Encoded Proteins
adrenergic, beta-2-, receptor, surface
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
Activation of ADRB2 on NOD2/TLR2-stimulated dendritic cells biases the cell priming ability towards an Th17 immune response. (Demonstrated in murine model)
InnateDB Annotation from Orthologs
Summary
[Mus musculus] Activation of Adrb2 on Nod2/Tlr2-stimulated dendritic cells biases the cell priming ability towards an Th17 immune response.
Entrez Gene
Summary This gene encodes beta-2-adrenergic receptor which is a member of the G protein-coupled receptor superfamily. This receptor is directly associated with one of its ultimate effectors, the class C L-type calcium channel Ca(V)1.2. This receptor-channel complex also contains a G protein, an adenylyl cyclase, cAMP-dependent kinase, and the counterbalancing phosphatase, PP2A. The assembly of the signaling complex provides a mechanism that ensures specific and rapid signaling by this G protein-coupled receptor. This gene is intronless. Different polymorphic forms, point mutations, and/or downregulation of this gene are associated with nocturnal asthma, obesity and type 2 diabetes. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:148825245-148828687
Strand Forward strand
Band q32
Transcripts
ENST00000305988 ENSP00000305372
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 336 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 336 [view]
Protein-Protein 335 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004930 G-protein coupled receptor activity
GO:0004941 beta2-adrenergic receptor activity
GO:0005515 protein binding
GO:0008179 adenylate cyclase binding
GO:0015459 potassium channel regulator activity
GO:0019899 enzyme binding
GO:0042803 protein homodimerization activity
GO:0051380 norepinephrine binding
Biological Process
GO:0001993 regulation of systemic arterial blood pressure by norepinephrine-epinephrine
GO:0002024 diet induced thermogenesis
GO:0002025 vasodilation by norepinephrine-epinephrine involved in regulation of systemic arterial blood pressure
GO:0002028 regulation of sodium ion transport
GO:0002032 desensitization of G-protein coupled receptor protein signaling pathway by arrestin
GO:0006898 receptor-mediated endocytosis
GO:0007166 cell surface receptor signaling pathway
GO:0007171 activation of transmembrane receptor protein tyrosine kinase activity
GO:0007186 G-protein coupled receptor signaling pathway
GO:0007188 adenylate cyclase-modulating G-protein coupled receptor signaling pathway
GO:0007189 adenylate cyclase-activating G-protein coupled receptor signaling pathway
GO:0007190 activation of adenylate cyclase activity
GO:0008333 endosome to lysosome transport
GO:0009409 response to cold
GO:0030501 positive regulation of bone mineralization
GO:0031398 positive regulation of protein ubiquitination
GO:0031649 heat generation
GO:0040015 negative regulation of multicellular organism growth
GO:0042312 regulation of vasodilation
GO:0043410 positive regulation of MAPK cascade
GO:0045087 innate immune response (InnateDB)
GO:0045453 bone resorption
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0045986 negative regulation of smooth muscle contraction
GO:0050873 brown fat cell differentiation
GO:0071875 adrenergic receptor signaling pathway
Cellular Component
GO:0005634 nucleus
GO:0005764 lysosome
GO:0005768 endosome
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0016324 apical plasma membrane
GO:0043235 receptor complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
G alpha (s) signalling events pathway
Class A/1 (Rhodopsin-like receptors) pathway
Signaling by GPCR pathway
Amine ligand-binding receptors pathway
Signal Transduction pathway
GPCR downstream signaling pathway
Adrenoceptors pathway
GPCR ligand binding pathway
KEGG
Calcium signaling pathway pathway
Neuroactive ligand-receptor interaction pathway
Endocytosis pathway
Salivary secretion pathway
INOH
PID BIOCARTA
Role of ?-arrestins in the activation and targeting of map kinases [Biocarta view]
Corticosteroids and cardioprotection [Biocarta view]
Phospholipase c-epsilon pathway [Biocarta view]
Cystic fibrosis transmembrane conductance regulator (cftr) and beta 2 adrenergic receptor (b2ar) pathway [Biocarta view]
Ss-arrestins in gpcr desensitization [Biocarta view]
Chrebp regulation by carbohydrates and camp [Biocarta view]
Activation of camp-dependent protein kinase pka [Biocarta view]
Roles of ? arrestin dependent recruitment of src kinases in gpcr signaling [Biocarta view]
Ion channels and their functional role in vascular endothelium [Biocarta view]
Activation of csk by camp-dependent protein kinase inhibits signaling through the t cell receptor [Biocarta view]
PID NCI
Arf6 trafficking events
Arf6 signaling events
Cross-References
SwissProt P07550
TrEMBL Q9BYZ0 X5DQM5
UniProt Splice Variant
Entrez Gene 154
UniGene Hs.2551 Hs.721212
RefSeq NM_000024
HUGO HGNC:286
OMIM 109690
CCDS CCDS4292
HPRD 00187
IMGT
EMBL AF022953 AF022954 AF022955 AF022956 AF169225 AF202305 AF203386 AK223025 AK313151 AY011291 AY136741 BC012481 BC063486 BC073856 CH471062 DQ094845 EU332834 J02960 KJ534762 M15169 X04827 Y00106
GenPept AAA88015 AAA88017 AAB82148 AAB82149 AAB82150 AAB82151 AAD48036 AAF17569 AAF20199 AAG35451 AAH12481 AAH63486 AAH73856 AAN01267 AAY88739 ABY87523 AHW56402 BAD96745 BAG35969 CAA28511 CAA68289 EAW61798
RNA Seq Atlas 154