Version 5.4
Homo sapiens Gene: MARK2
Summary
InnateDB Gene IDBG-52754.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MARK2
Gene Name MAP/microtubule affinity-regulating kinase 2
Synonyms EMK-1; EMK1; PAR-1; Par-1b; Par1b
Species Homo sapiens
Ensembl Gene ENSG00000072518
Encoded Proteins
IDBP-52756
MAP/microtubule affinity-regulating kinase 2
IDBP-52760
MAP/microtubule affinity-regulating kinase 2
IDBP-52764
MAP/microtubule affinity-regulating kinase 2
IDBP-295281
MAP/microtubule affinity-regulating kinase 2
IDBP-295280
MAP/microtubule affinity-regulating kinase 2
IDBP-376959
MAP/microtubule affinity-regulating kinase 2
IDBP-481010
MAP/microtubule affinity-regulating kinase 2
IDBP-480859
MAP/microtubule affinity-regulating kinase 2
IDBP-485089
MAP/microtubule affinity-regulating kinase 2
IDBP-481564
MAP/microtubule affinity-regulating kinase 2
IDBP-476343
MAP/microtubule affinity-regulating kinase 2
IDBP-600315
MAP/microtubule affinity-regulating kinase 2
IDBP-598432
MAP/microtubule affinity-regulating kinase 2
IDBP-585050
MAP/microtubule affinity-regulating kinase 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the Par-1 family of serine/threonine protein kinases. The protein is an important regulator of cell polarity in epithelial and neuronal cells, and also controls the stability of microtubules through phosphorylation and inactivation of several microtubule-associating proteins. The protein localizes to cell membranes. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:63838928-63911019
Strand Forward strand
Band q13.1
Transcripts
ENST00000350490 ENSP00000294247
ENST00000377810 ENSP00000367041
ENST00000361128 ENSP00000355091
ENST00000402010 ENSP00000385751
ENST00000408948 ENSP00000386128
ENST00000425897 ENSP00000415494
ENST00000508192 ENSP00000425765
ENST00000502399 ENSP00000423452
ENST00000509502 ENSP00000423974
ENST00000512060 ENSP00000423844
ENST00000513765 ENSP00000421075
ENST00000543220 ENSP00000444956
ENST00000543674 ENSP00000444859
ENST00000540169 ENSP00000437509
ENST00000535116
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 79 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Experimentally validated
Total 79 [view]
Protein-Protein 79 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 5 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000287 magnesium ion binding
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0008289 lipid binding
GO:0016772 transferase activity, transferring phosphorus-containing groups
GO:0044822 poly(A) RNA binding
GO:0050321 tau-protein kinase activity
Biological Process
GO:0001764 neuron migration
GO:0006468 protein phosphorylation
GO:0010976 positive regulation of neuron projection development
GO:0016055 Wnt signaling pathway
GO:0030010 establishment of cell polarity
GO:0035556 intracellular signal transduction
GO:0045197 establishment or maintenance of epithelial cell apical/basal polarity
GO:0046777 protein autophosphorylation
GO:0050770 regulation of axonogenesis
GO:0051493 regulation of cytoskeleton organization
Cellular Component
GO:0005634 nucleus
GO:0005884 actin filament
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016328 lateral plasma membrane
GO:0045180 basal cortex
GO:0097427 microtubule bundle
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000024969
View Gene Order
ENSBTAG00000007825
Not yet available
Pathways
NETPATH
NetPath_8
Wnt pathway
NetPath_9
TNFalpha pathway
REACTOME
KEGG
INOH
PID NCI
lkb1_pathway
LKB1 signaling events
notch_pathway
Notch signaling pathway
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.567261
RefSeq NM_001039469 NM_001163296 NM_001163297 NM_004954 NM_017490 XM_006718441 XM_006718442 XM_006718446
HUGO
OMIM
CCDS CCDS41665 CCDS53649 CCDS53650 CCDS53651 CCDS8051
HPRD 02753
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca