InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: DUSP3

Summary

InnateDB Gene

IDBG-52945.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

DUSP3

Gene Name

dual specificity phosphatase 3

Synonyms

VHR

Species

Homo sapiens

Ensembl Gene

ENSG00000108861

Encoded Proteins

IDBP-52947

dual specificity phosphatase 3

IDBP-758270

IDBP-758454

IDBP-761070

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene maps in a region that contains the BRCA1 locus which confers susceptibility to breast and ovarian cancer. Although DUSP3 is expressed in both breast and ovarian tissues, mutation screening in breast cancer pedigrees and in sporadic tumors was negative, leading to the conclusion that this gene is not BRCA1. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 17:43766121-43778988

Strand

Reverse strand

Band

q21.31

Transcripts

ENST00000226004	ENSP00000226004
ENST00000591618
ENST00000590753	ENSP00000466069
ENST00000590342	ENSP00000467424
ENST00000590935	ENSP00000468604

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 17 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	17 [view]
Protein-Protein	15 [view]
Protein-DNA	1 [view]
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004721	phosphoprotein phosphatase activity
GO:0004725	protein tyrosine phosphatase activity
GO:0008138	protein tyrosine/serine/threonine phosphatase activity
GO:0016791	phosphatase activity
GO:0033549	MAP kinase phosphatase activity

Biological Process

GO:0000188	inactivation of MAPK activity
GO:0001701	in utero embryonic development
GO:0002224	toll-like receptor signaling pathway
GO:0002755	MyD88-dependent toll-like receptor signaling pathway
GO:0002756	MyD88-independent toll-like receptor signaling pathway
GO:0006470	protein dephosphorylation
GO:0016311	dephosphorylation
GO:0034134	toll-like receptor 2 signaling pathway
GO:0034138	toll-like receptor 3 signaling pathway
GO:0034142	toll-like receptor 4 signaling pathway
GO:0034146	toll-like receptor 5 signaling pathway
GO:0034162	toll-like receptor 9 signaling pathway
GO:0034166	toll-like receptor 10 signaling pathway
GO:0035335	peptidyl-tyrosine dephosphorylation
GO:0035666	TRIF-dependent toll-like receptor signaling pathway
GO:0038123	toll-like receptor TLR1:TLR2 signaling pathway
GO:0038124	toll-like receptor TLR6:TLR2 signaling pathway
GO:0043409	negative regulation of MAPK cascade
GO:0045087	innate immune response
GO:0045931	positive regulation of mitotic cell cycle
GO:0046329	negative regulation of JNK cascade
GO:0048011	neurotrophin TRK receptor signaling pathway
GO:0050860	negative regulation of T cell receptor signaling pathway
GO:0050868	negative regulation of T cell activation
GO:0051403	stress-activated MAPK cascade
GO:0070373	negative regulation of ERK1 and ERK2 cascade