Homo sapiens Gene: CSNK1A1
Summary
InnateDB Gene IDBG-52965.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CSNK1A1
Gene Name casein kinase 1, alpha 1
Synonyms CK1; CK1a; CKIa; HEL-S-77p; HLCDGP1; PRO2975;
Species Homo sapiens
Ensembl Gene ENSG00000113712
Encoded Proteins
casein kinase 1, alpha 1
casein kinase 1, alpha 1
casein kinase 1, alpha 1
casein kinase 1, alpha 1
casein kinase 1, alpha 1
casein kinase 1, alpha 1
casein kinase 1, alpha 1
casein kinase 1, alpha 1
casein kinase 1, alpha 1
casein kinase 1, alpha 1
casein kinase 1, alpha 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.
Gene Information
Type Protein coding
Genomic Location Chromosome 5:149492197-149551552
Strand Reverse strand
Band q32
Transcripts
ENST00000261798 ENSP00000261798
ENST00000377843 ENSP00000367074
ENST00000504676 ENSP00000426747
ENST00000515435 ENSP00000427031
ENST00000515768 ENSP00000421689
ENST00000503350 ENSP00000425366
ENST00000523203 ENSP00000430252
ENST00000515748 ENSP00000421268
ENST00000606719 ENSP00000475319
ENST00000606826 ENSP00000475969
ENST00000606299 ENSP00000475633
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 102 experimentally validated interaction(s) in this database.
Experimentally validated
Total 102 [view]
Protein-Protein 101 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 1 [view]
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016772 transferase activity, transferring phosphorus-containing groups
Biological Process
GO:0006468 protein phosphorylation
GO:0007067 mitotic nuclear division
GO:0007165 signal transduction
GO:0007166 cell surface receptor signaling pathway
GO:0008152 metabolic process
GO:0016055 Wnt signaling pathway
Cellular Component
GO:0000777 condensed chromosome kinetochore
GO:0005813 centrosome
GO:0005829 cytosol
GO:0005847 mRNA cleavage and polyadenylation specificity factor complex
GO:0016020 membrane
GO:0016607 nuclear speck
Orthologs
No orthologs found for this gene
Pathways
NETPATH
Wnt pathway
REACTOME
truncated APC mutants destabilize the destruction complex pathway
Beta-catenin phosphorylation cascade pathway
AXIN mutants destabilize the destruction complex, activating WNT signaling pathway
APC truncation mutants are not K63 polyubiquitinated pathway
Signaling by Hedgehog pathway
AMER1 mutants destabilize the destruction complex pathway
misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling pathway
Signaling by WNT in cancer pathway
AXIN missense mutants destabilize the destruction complex pathway
Signaling by Wnt pathway
disassembly of the destruction complex and recruitment of AXIN to the membrane pathway
APC truncation mutants have impaired AXIN binding pathway
Degradation of GLI2 by the proteasome pathway
GLI3 is processed to GLI3R by the proteasome pathway
Degradation of beta-catenin by the destruction complex pathway
T41 mutants of beta-catenin aren't phosphorylated pathway
Signal Transduction pathway
Hedgehog 'off' state pathway
misspliced GSK3beta mutants stabilize beta-catenin pathway
S45 mutants of beta-catenin aren't phosphorylated pathway
deletions in the AMER1 gene destabilize the destruction complex pathway
S33 mutants of beta-catenin aren't phosphorylated pathway
truncations of AMER1 destabilize the destruction complex pathway
phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex pathway
TCF dependent signaling in response to WNT pathway
deletions in the AXIN genes in hepatocellular carcinoma result in elevated WNT signaling pathway
RNF mutants show enhanced WNT signaling and proliferation pathway
TCF7L2 mutants don't bind CTBP pathway
XAV939 inhibits tankyrase, stabilizing AXIN pathway
S37 mutants of beta-catenin aren't phosphorylated pathway
Disease pathway
KEGG
Wnt signaling pathway pathway
Hedgehog signaling pathway pathway
INOH
IL-7 signaling pathway
JAK STAT pathway and regulation pathway
EPO signaling pathway pathway
VEGF signaling pathway pathway
PID BIOCARTA
PID NCI
Presenilin action in Notch and Wnt signaling
Role of Calcineurin-dependent NFAT signaling in lymphocytes
Noncanonical Wnt signaling pathway
Cross-References
SwissProt
TrEMBL B4DFH4 E7ETM0
UniProt Splice Variant
Entrez Gene 1452
UniGene Hs.629008 Hs.638791 Hs.644579 Hs.712879
RefSeq NM_001271742 NM_001271741 NM_001025105 NM_001892
HUGO HGNC:2451
OMIM 600505
CCDS CCDS64291 CCDS47304 CCDS47303
HPRD 02739
IMGT
EMBL AC021078 AK294099
GenPept BAG57435
RNA Seq Atlas 1452